Leukocyte-99mTc uptake in Crohn's disease: does it show subclinical disease?

Aim: To evaluate inflammatory activity in patients with Crohn's disease (CD) using technetium-99m-hexamethylpropyleneamine oxime (99mTc-HMPAO) granulocyte scintigraphy. Methods: Twenty patients (7 male and 13 female) with CD and five healthy volunteers were selected for 99mTc-HMPAO granulocyte...

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Autores: Mota, Luciene G., Coelho, Luiz G., Simal, Carlos J.R., Ferrari, Maria L.A., Toledo, Clodomiro, Martín-Comín, Josep, Diniz, Simone O.F., Cardoso, Valbert N.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/189230
Acceso en línea:https://hdl.handle.net/2445/189230
Access Level:acceso abierto
Palabra clave:Malaltia de Crohn
Inflamació
Leucòcits
Crohn's disease
Inflammation
Leucocytes
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spelling Leukocyte-99mTc uptake in Crohn's disease: does it show subclinical disease?Mota, Luciene G.Coelho, Luiz G.Simal, Carlos J.R.Ferrari, Maria L.A.Toledo, ClodomiroMartín-Comín, JosepDiniz, Simone O.F.Cardoso, Valbert N.Malaltia de CrohnInflamacióLeucòcitsCrohn's diseaseInflammationLeucocytesAim: To evaluate inflammatory activity in patients with Crohn's disease (CD) using technetium-99m-hexamethylpropyleneamine oxime (99mTc-HMPAO) granulocyte scintigraphy. Methods: Twenty patients (7 male and 13 female) with CD and five healthy volunteers were selected for 99mTc-HMPAO granulocyte scintigraphy. The Crohn's Disease Activity Index (CDAI), blood tests and C-reactive protein (CRP) of each patient were performed 7 d before the scintigraphic images. The leukocytes were labeled according to the International Society of Radiolabeled Blood Elements (ISORBE) consensus protocol and the scintigraphic images, including single photon emission computed tomography, were obtained 30 min and 2 h after injection of the radiolabeled leukocytes. Results: The labeling yield of the leukocytes with the lipophilic complex 99mTc-HMPAO was 55.0% +/- 10%. Six of the 20 patients (30%) presented congruent results for the three parameters investigated (CDAI, Scintigraphic Index and CRP). On the other hand, 14 patients (70%) did not show congruent results. There was no significant correlation between the indices analyzed according to the Spearman test (P > 0.05, n = 20). Conclusion: The results suggest that 99mTc-HMPAO-labeled leukocyte scintigraphy could be important for determining inflammatory activity in CD even in the absence of clinical symptoms.Baishideng Publishing Group Inc2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/189230Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3748/wjg.v16.i3.365World Journal of Gastroenterology, 2010, vol. 16, num. 3, p. 365-371https://doi.org/10.3748/wjg.v16.i3.365cc-by-nc (c) Mota, Luciene G. et al., 2010https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1892302026-05-27T06:46:51Z
dc.title.none.fl_str_mv Leukocyte-99mTc uptake in Crohn's disease: does it show subclinical disease?
title Leukocyte-99mTc uptake in Crohn's disease: does it show subclinical disease?
spellingShingle Leukocyte-99mTc uptake in Crohn's disease: does it show subclinical disease?
Mota, Luciene G.
Malaltia de Crohn
Inflamació
Leucòcits
Crohn's disease
Inflammation
Leucocytes
title_short Leukocyte-99mTc uptake in Crohn's disease: does it show subclinical disease?
title_full Leukocyte-99mTc uptake in Crohn's disease: does it show subclinical disease?
title_fullStr Leukocyte-99mTc uptake in Crohn's disease: does it show subclinical disease?
title_full_unstemmed Leukocyte-99mTc uptake in Crohn's disease: does it show subclinical disease?
title_sort Leukocyte-99mTc uptake in Crohn's disease: does it show subclinical disease?
dc.creator.none.fl_str_mv Mota, Luciene G.
Coelho, Luiz G.
Simal, Carlos J.R.
Ferrari, Maria L.A.
Toledo, Clodomiro
Martín-Comín, Josep
Diniz, Simone O.F.
Cardoso, Valbert N.
author Mota, Luciene G.
author_facet Mota, Luciene G.
Coelho, Luiz G.
Simal, Carlos J.R.
Ferrari, Maria L.A.
Toledo, Clodomiro
Martín-Comín, Josep
Diniz, Simone O.F.
Cardoso, Valbert N.
author_role author
author2 Coelho, Luiz G.
Simal, Carlos J.R.
Ferrari, Maria L.A.
Toledo, Clodomiro
Martín-Comín, Josep
Diniz, Simone O.F.
Cardoso, Valbert N.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia de Crohn
Inflamació
Leucòcits
Crohn's disease
Inflammation
Leucocytes
topic Malaltia de Crohn
Inflamació
Leucòcits
Crohn's disease
Inflammation
Leucocytes
description Aim: To evaluate inflammatory activity in patients with Crohn's disease (CD) using technetium-99m-hexamethylpropyleneamine oxime (99mTc-HMPAO) granulocyte scintigraphy. Methods: Twenty patients (7 male and 13 female) with CD and five healthy volunteers were selected for 99mTc-HMPAO granulocyte scintigraphy. The Crohn's Disease Activity Index (CDAI), blood tests and C-reactive protein (CRP) of each patient were performed 7 d before the scintigraphic images. The leukocytes were labeled according to the International Society of Radiolabeled Blood Elements (ISORBE) consensus protocol and the scintigraphic images, including single photon emission computed tomography, were obtained 30 min and 2 h after injection of the radiolabeled leukocytes. Results: The labeling yield of the leukocytes with the lipophilic complex 99mTc-HMPAO was 55.0% +/- 10%. Six of the 20 patients (30%) presented congruent results for the three parameters investigated (CDAI, Scintigraphic Index and CRP). On the other hand, 14 patients (70%) did not show congruent results. There was no significant correlation between the indices analyzed according to the Spearman test (P > 0.05, n = 20). Conclusion: The results suggest that 99mTc-HMPAO-labeled leukocyte scintigraphy could be important for determining inflammatory activity in CD even in the absence of clinical symptoms.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/189230
url https://hdl.handle.net/2445/189230
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3748/wjg.v16.i3.365
World Journal of Gastroenterology, 2010, vol. 16, num. 3, p. 365-371
https://doi.org/10.3748/wjg.v16.i3.365
dc.rights.none.fl_str_mv cc-by-nc (c) Mota, Luciene G. et al., 2010
https://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Mota, Luciene G. et al., 2010
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Baishideng Publishing Group Inc
publisher.none.fl_str_mv Baishideng Publishing Group Inc
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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