Risk factors and rate of recurrence after Mohs surgery in basal cell and squamous cell carcinomas: a nationwide prospective cohort (REGESMOHS, Spanish Registry of Mohs Surgery)

Randomized studies to assess the efficacy of Mohs micrographic surgery in basal cell and squamous cell carcinomas are limited by methodological and ethical issues and a lack of long follow-up periods. This study presents the "real-life" results of a nationwide 7-years cohort on basal cell...

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Autores: Tomás-Velázquez, A. (Alejandra)|||/items/cf4d9572-46c9-42ea-8b01-d2450ddcd205, Sanmartin-Jiménez, O. (Onofre)|||/items/7b6d8f5b-00bc-4dd0-abb6-98b702a05ff5, Garcés, J.R. (Joan R.)|||/items/e9c6615c-93f3-4758-bcc1-b8a52d61bcda, Rodríguez-Prieto, M.A. (Manuel A.)|||/items/710b7844-117b-46e0-b0cd-ea5cd4586d09, Ruiz-Salas, V. (Verónica)|||/items/9100ed8e-f0e1-4a4d-bcc5-f2a4a89ff094, Eusebio-Murillo, E. (Esther) de|||/items/18843f7a-a4a0-46ef-a70b-bc269f511cb0, Miñano-Medrano, R. (Román)|||/items/4521d9c8-a882-4325-b4f7-f3a37d08c184, Escutia-Muñoz, B. (Begoña)|||/items/7196248c-cfc6-45b3-8270-7d1fcea53ce7, Flórez-Menéndez, A. (Ángeles)|||/items/c477f3ef-0a56-498b-b4f2-c60c5ce3ace6, Artola-Igarza, J.L. (Juan L.)|||/items/51a2a501-8f75-4d65-af94-4d27d09c3899, Alfaro-Rubio, A. ( Alberto)|||/items/4b30aeea-8254-4311-9f18-bca41a3908c1, Gil-Sánchez, M.P. (María Pilar)|||/items/c1392c93-6f46-47b8-8314-a1b096b90314, Delgado-Jiménez, Y. (Yolanda)|||/items/64799e95-5c08-4bd5-ac45-2dfbc84ea16b, Sanchez-Schmidt, J.M. (Julia M.)|||/items/8f72e747-bb58-40e5-aa46-d01b37f27386, Allende-Markixana, I. (Irati)|||/items/0f4b3706-63c1-425b-8e76-f540761dee79, Alonso-Pacheco, L. (L.)|||/items/39dc3a8b-c52d-486e-a378-1e24c65ed2df, García-Bracamonte, B. (Beatriz)|||/items/471d820f-f267-44ed-84bc-bdfc651c7309, Cueva-Dobao, P. (Pablo) de la|||/items/11888d2e-00c1-456b-affa-33fbd256adee, Navarro-Tejedor, R. (Raquel)|||/items/48d84d68-b34e-47a8-8802-88d33d80f1c7, Ciudad-Blanco, C. (Cristina)|||/items/34cf865c-4a77-44a1-a73c-3da71e720977, González, L. (Lucía)|||/items/ed7b5adb-a80b-4b10-8463-bf713c8b6b66, Vázquez-Veiga, H. (Hugo)|||/items/0c62020f-38d0-4555-8d10-26bc40ee906d, Cano-Martínez, N. (Natividad)|||/items/dcef47a8-a4d5-467a-bb61-af19b6588550, Vilarrasa-Rull, E. (Eva)|||/items/7a8522fd-7e7b-42ff-9ee6-65f674375542, Sánchez-Sambucety, P. (Pedro)|||/items/5719fa91-cb3e-406d-96a2-c59af25c1557, Lopez-Estebaranz, J.L. (J. L.)|||/items/3057dd78-33fb-490c-8c02-b7f394effda3, Botella-Estrada, R. (Rafael)|||/items/599c5849-8de7-402e-ac7e-1f686f51097f, Gonzalez-Sixto, B.(Beatriz)|||/items/734a114f-a3e5-402b-9a47-60c96526a606, Martorell-Calatayud, A. (Antonio)|||/items/b8dd2624-e49c-4441-bed6-6a5ff206fd49, Morales-Gordillo, V. (Victoriano)|||/items/9d1d049c-47ae-4db6-b632-bffc661d939c, Toll-Abelló, A. (Agustí)|||/items/2ba34905-87e1-4251-ba99-5bab9d32b14b, Ocerin-Guerra, I. (Izascun)|||/items/2d5e9fb6-ffc9-461a-8431-b29087cbeeed, Mayor-Arenal, M. (Matías)|||/items/1a81ae25-d3fa-4d66-9b90-3ac3041ce52e, Suárez-Fernández, R. (Ricardo)|||/items/34fbb82c-251f-4ff9-a4f7-969e7c030427, Sainz-Gaspar, L. (Laura)|||/items/72d282cd-bdd2-46af-b613-69b2a43b4b36, Descalzo, M.A. (Miguel A.)|||/items/fba2554c-b667-4640-a027-d2bef5f5d0dc, García-Doval, I. (Ignacio)|||/items/1e7e2d1b-b0c4-48fd-bbf9-9cb3bc06f5e6, Redondo-Bellón, P. (Pedro)|||/items/c82abb7b-9e9c-4498-a2fd-aac715171930
Tipo de documento: artigo
Data de publicação:2021
País:España
Recursos:Universidad de Navarra
Repositório:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglês
OAI Identifier:oai:dadun.unav.edu:10171/68592
Acesso em linha:https://hdl.handle.net/10171/68592
Access Level:Acceso aberto
Palavra-chave:Materias Investigacion::Ciencias de la Salud::Dermatología
Mohs Surgery
Squamous cell carcinoma
Basal cell carcinoma
Recurrence
Risk factors
Descrição
Resumo:Randomized studies to assess the efficacy of Mohs micrographic surgery in basal cell and squamous cell carcinomas are limited by methodological and ethical issues and a lack of long follow-up periods. This study presents the "real-life" results of a nationwide 7-years cohort on basal cell carcinoma and squamous cell carcinoma treated with Mohs micrographic surgery. A prospective cohort was conducted in 22 Spanish centres (from July 2013 to February 2020) and a multivariate analysis, including characteristics of patients, tumours, surgeries and follow-up, was performed. A total of 4,402 patients followed up for 12,111 patient-years for basal cell carcinoma, and 371 patients with 915 patient-years of follow-up for squamous cell carcinoma were recruited. Risk factors for recurrence included age, non-primary tumours and more stages or unfinished surgeries for both tumours, and immunosuppression for squamous cell carcinoma. Incidence rates of recurrence were 1.3 per 100 person-years for basal cell carcinoma (95% confidence interval 1.1-1.5) and 4.5 for squamous cell carcinoma (95% confidence interval 3.3-6.1), being constant over time (0-5 years). In conclusion, follow-up strategies should be equally intense for at least the first 5 years, with special attention paid to squamous cell carcinoma (especially in immunosuppressed patients), elderly patients, non-primary tumours, and those procedures requiring more stages, or unfinished surgeries.

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