Sex-specific differences in intestinal microbiota associated with cardiovascular diseases

Background Cardiovascular diseases (CVD), including coronary heart disease (CHD), display a higher prevalence in men than women. This study aims to evaluate the variations in the intestinal microbiota between men and women aficted with CHD and delineate these against a non-CVD control group for each...

ver descrição completa

Detalhes bibliográficos
Autores: García Fernández, Helena, Arenas de Larriva, Antonio Pablo, López Moreno, Javier, Gutiérrez Mariscal, Francisco Miguel, Romero Cabrera, Juan Luis, Molina Abril, Helena, Torres Peña, José David, Rodríguez Cano, Diego, Malagón Poyato, María del Mar, Ordovás Muñoz, José María, Delgado Lista, Javier, Pérez Martínez, Pablo, López Miranda, José, Camargo García, Antonio
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2024
País:España
Recursos:Universidad de Sevilla (US)
Repositório:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/154991
Acesso em linha:https://hdl.handle.net/11441/154991
https://doi.org/10.1186/s13293-024-00582-7
Access Level:Acceso aberto
Palavra-chave:Gut microbiota
Dysbiosis
Sexual dimorphism
Cardiovascular diseases
CORDIOPREV
id ES_9e5bd4794c2a9e3bcef29f44ffd7253d
oai_identifier_str oai:idus.us.es:11441/154991
network_acronym_str ES
network_name_str España
repository_id_str
spelling Sex-specific differences in intestinal microbiota associated with cardiovascular diseasesGarcía Fernández, HelenaArenas de Larriva, Antonio PabloLópez Moreno, JavierGutiérrez Mariscal, Francisco MiguelRomero Cabrera, Juan LuisMolina Abril, HelenaTorres Peña, José DavidRodríguez Cano, DiegoMalagón Poyato, María del MarOrdovás Muñoz, José MaríaDelgado Lista, JavierPérez Martínez, PabloLópez Miranda, JoséCamargo García, AntonioGut microbiotaDysbiosisSexual dimorphismCardiovascular diseasesCORDIOPREVBackground Cardiovascular diseases (CVD), including coronary heart disease (CHD), display a higher prevalence in men than women. This study aims to evaluate the variations in the intestinal microbiota between men and women aficted with CHD and delineate these against a non-CVD control group for each sex. Methods Our research was conducted in the framework of the CORDIOPREV study, a clinical trial which involved 837 men and 165 women with CHD. We contrasted our fndings with a reference group of 375 individuals (270 men, 105 women) without CVD. The intestinal microbiota was examined through 16S metagenomics on the Illumina MiSeq platform and the data processed with Quiime2 software. Results Our results showed a sex-specifc variation (beta diversity) in the intestinal microbiota, while alpha-biodiver‑ sity remained consistent across both sexes. Linear discriminant analysis efect size (LEfSe) analysis revealed sex-centric alterations in the intestinal microbiota linked to CVD. Moreover, using random forest (RF) methodology, we identifed seven bacterial taxa—g_UBA1819 (Ruminococcaceae), g_Bilophila, g_Subdoligranulum, g_Phascolarctobacterium, f_Barnesiellaceae, g_Ruminococcus, and an unknown genus from the Ruminococcaceae family (Ruminococcaceae incertae sedis)—as key discriminators between men and women diagnosed with CHD. The same taxa also emerged as critical discriminators between CHD-aficted and non-CVD individuals, when analyzed separately by sex. Conclusion Our fndings suggest a sex-specifc dysbiosis in the intestinal microbiota linked to CHD, potentially con‑ tributing to the sex disparity observed in CVD incidence.BMCMatemática Aplicada ITIC245: Topological Pattern Analysis, Recognition and LearningJunta de Andalucía2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/154991https://doi.org/10.1186/s13293-024-00582-7reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésBiology of Sex Differences, 15 (7).CP14/00114CPII19/00007C1-00012022https://bsd.biomedcentral.com/articles/10.1186/s13293-024-00582-7info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1549912026-06-17T12:51:07Z
dc.title.none.fl_str_mv Sex-specific differences in intestinal microbiota associated with cardiovascular diseases
title Sex-specific differences in intestinal microbiota associated with cardiovascular diseases
spellingShingle Sex-specific differences in intestinal microbiota associated with cardiovascular diseases
García Fernández, Helena
Gut microbiota
Dysbiosis
Sexual dimorphism
Cardiovascular diseases
CORDIOPREV
title_short Sex-specific differences in intestinal microbiota associated with cardiovascular diseases
title_full Sex-specific differences in intestinal microbiota associated with cardiovascular diseases
title_fullStr Sex-specific differences in intestinal microbiota associated with cardiovascular diseases
title_full_unstemmed Sex-specific differences in intestinal microbiota associated with cardiovascular diseases
title_sort Sex-specific differences in intestinal microbiota associated with cardiovascular diseases
dc.creator.none.fl_str_mv García Fernández, Helena
Arenas de Larriva, Antonio Pablo
López Moreno, Javier
Gutiérrez Mariscal, Francisco Miguel
Romero Cabrera, Juan Luis
Molina Abril, Helena
Torres Peña, José David
Rodríguez Cano, Diego
Malagón Poyato, María del Mar
Ordovás Muñoz, José María
Delgado Lista, Javier
Pérez Martínez, Pablo
López Miranda, José
Camargo García, Antonio
author García Fernández, Helena
author_facet García Fernández, Helena
Arenas de Larriva, Antonio Pablo
López Moreno, Javier
Gutiérrez Mariscal, Francisco Miguel
Romero Cabrera, Juan Luis
Molina Abril, Helena
Torres Peña, José David
Rodríguez Cano, Diego
Malagón Poyato, María del Mar
Ordovás Muñoz, José María
Delgado Lista, Javier
Pérez Martínez, Pablo
López Miranda, José
Camargo García, Antonio
author_role author
author2 Arenas de Larriva, Antonio Pablo
López Moreno, Javier
Gutiérrez Mariscal, Francisco Miguel
Romero Cabrera, Juan Luis
Molina Abril, Helena
Torres Peña, José David
Rodríguez Cano, Diego
Malagón Poyato, María del Mar
Ordovás Muñoz, José María
Delgado Lista, Javier
Pérez Martínez, Pablo
López Miranda, José
Camargo García, Antonio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Matemática Aplicada I
TIC245: Topological Pattern Analysis, Recognition and Learning
Junta de Andalucía
dc.subject.none.fl_str_mv Gut microbiota
Dysbiosis
Sexual dimorphism
Cardiovascular diseases
CORDIOPREV
topic Gut microbiota
Dysbiosis
Sexual dimorphism
Cardiovascular diseases
CORDIOPREV
description Background Cardiovascular diseases (CVD), including coronary heart disease (CHD), display a higher prevalence in men than women. This study aims to evaluate the variations in the intestinal microbiota between men and women aficted with CHD and delineate these against a non-CVD control group for each sex. Methods Our research was conducted in the framework of the CORDIOPREV study, a clinical trial which involved 837 men and 165 women with CHD. We contrasted our fndings with a reference group of 375 individuals (270 men, 105 women) without CVD. The intestinal microbiota was examined through 16S metagenomics on the Illumina MiSeq platform and the data processed with Quiime2 software. Results Our results showed a sex-specifc variation (beta diversity) in the intestinal microbiota, while alpha-biodiver‑ sity remained consistent across both sexes. Linear discriminant analysis efect size (LEfSe) analysis revealed sex-centric alterations in the intestinal microbiota linked to CVD. Moreover, using random forest (RF) methodology, we identifed seven bacterial taxa—g_UBA1819 (Ruminococcaceae), g_Bilophila, g_Subdoligranulum, g_Phascolarctobacterium, f_Barnesiellaceae, g_Ruminococcus, and an unknown genus from the Ruminococcaceae family (Ruminococcaceae incertae sedis)—as key discriminators between men and women diagnosed with CHD. The same taxa also emerged as critical discriminators between CHD-aficted and non-CVD individuals, when analyzed separately by sex. Conclusion Our fndings suggest a sex-specifc dysbiosis in the intestinal microbiota linked to CHD, potentially con‑ tributing to the sex disparity observed in CVD incidence.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/154991
https://doi.org/10.1186/s13293-024-00582-7
url https://hdl.handle.net/11441/154991
https://doi.org/10.1186/s13293-024-00582-7
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Biology of Sex Differences, 15 (7).
CP14/00114
CPII19/00007
C1-00012022
https://bsd.biomedcentral.com/articles/10.1186/s13293-024-00582-7
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414820234657792
score 15.301603

Registros relacionados