Molecular Imaging of p53 in Mouse Models of Cancer Using a Radiolabeled Antibody TAT Conjugate with SPECT

Mutations of p53 protein occur in over half of all cancers, with profound effects on tumor biology. We present the first—to our knowledge—method for noninvasive visualization of p53 in tumor tissue in vivo, using SPECT, in 3 different models of cancer.

Detalles Bibliográficos
Autores: Alakonya, Hudson, Koustoulidou, Sofia, Hopkins, Samantha L., Veal, Mathew, Ajenjo, Javier, Sneddon, Deborah, Dias, Gemma, Mosley, Michael, Baguña Torres, Júlia, Amoroso, Francesca, Anderson, Amanda, Banham, Alison H., Cornelissen, Bart
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/419982
Acceso en línea:http://hdl.handle.net/10261/419982
Access Level:acceso abierto
Palabra clave:Molecular imaging
p53
Cancer
Pancreatic ductal adenocarcinoma
Descripción
Sumario:Mutations of p53 protein occur in over half of all cancers, with profound effects on tumor biology. We present the first—to our knowledge—method for noninvasive visualization of p53 in tumor tissue in vivo, using SPECT, in 3 different models of cancer.

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