Relationship Between Bioimpedance Vector Displacement and Renal Function After a Marathon in Non-elite Runners

Purpose: This study investigates the relationship between whole-body bioimpedance vector displacement, using bioelectrical impedance vector analysis (BIVA), and renal function through serum biomarkers [creatinine, urea, sodium, C-reactive protein (CRP), and creatine kinase] and urine biomarkers afte...

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Autores: Nescolarde, Lexa|||0000-0001-6861-5106, Roca, Emma|||0000-0002-2338-5877, Bogónez-Franco, Paco|||0000-0002-5364-231X, Hernández-Hermoso, José, Bayés-Genís, Antoni|||0000-0002-3044-197X, Ara del Rey, Jordi|||0000-0002-7281-9969
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:252620
Acceso en línea:https://ddd.uab.cat/record/252620
https://dx.doi.org/urn:doi:10.3389/fphys.2020.00352
Access Level:acceso abierto
Palabra clave:Marathon race
BIVA
Serum creatinine
C-reactive protein
Serum creatine kinase
AKI stage 1
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spelling Relationship Between Bioimpedance Vector Displacement and Renal Function After a Marathon in Non-elite RunnersNescolarde, Lexa|||0000-0001-6861-5106Roca, Emma|||0000-0002-2338-5877Bogónez-Franco, Paco|||0000-0002-5364-231XHernández-Hermoso, JoséBayés-Genís, Antoni|||0000-0002-3044-197XAra del Rey, Jordi|||0000-0002-7281-9969Marathon raceBIVASerum creatinineC-reactive proteinSerum creatine kinaseAKI stage 1Purpose: This study investigates the relationship between whole-body bioimpedance vector displacement, using bioelectrical impedance vector analysis (BIVA), and renal function through serum biomarkers [creatinine, urea, sodium, C-reactive protein (CRP), and creatine kinase] and urine biomarkers after a marathon. Methods: Bioimpedance measurements were taken among 19 non-elite runners at 24 h pre-race, immediately post-race, and at 48 h post-race. The bioimpedance measurements were analyzed by BIVA using the Hotelling's T2 test. The runners were divided according to a cutoff of serum creatinine level immediately post-race in G1 (<1.2 mg/dl of serum creatinine level) and G2 (≥1.2 mg/dl of serum creatinine level). The increase of the serum creatinine levels in 83% of G2 runners was related to acute kidney injury (AKI) stage 1. Results: Neither G1 nor G2 showed a creatinine clearance rate (CCr) lower than 60 ml/min. G2 showed a significant increase in CRP values at 48 h post-race vs baseline compared to G1 (P < 0.05), with over 5 mg/L (6.8-15.2) in 92% of the runners, and in CK values with over 215 U/L (282-1,882) at 48 h post-race in 100% of the runners. By BIVA, the 95% confidence ellipses of G2 showed shorter bioimpedance vectors than G1, with a noticeable minor Xc/H (P < 0.01), indicating an expansion on extracellular water and inflammation. The runners with 48 h post-race Xc/H values ≤30.5 Ω, with a decrease from -3 to -12% with respect to the Xc/H value at 24 h pre-race, indicated AKI stage 1 with 85.7% sensitivity and 91.7% specificity, with a direct correlation between AKI stage 1 with greater CRP values at 48 h post-race and bioimpedance vector displacement, but not with CK values at 48 h post-race. Conclusion: Through this data collection, it was evidenced that a transient reduction in renal function is more related to inflammatory factors than muscle damage. The BIVA method along with serum biomarkers could be used to follow up the kidney function in runners. 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/252620https://dx.doi.org/urn:doi:10.3389/fphys.2020.00352reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2526202026-06-06T12:50:31Z
dc.title.none.fl_str_mv Relationship Between Bioimpedance Vector Displacement and Renal Function After a Marathon in Non-elite Runners
title Relationship Between Bioimpedance Vector Displacement and Renal Function After a Marathon in Non-elite Runners
spellingShingle Relationship Between Bioimpedance Vector Displacement and Renal Function After a Marathon in Non-elite Runners
Nescolarde, Lexa|||0000-0001-6861-5106
Marathon race
BIVA
Serum creatinine
C-reactive protein
Serum creatine kinase
AKI stage 1
title_short Relationship Between Bioimpedance Vector Displacement and Renal Function After a Marathon in Non-elite Runners
title_full Relationship Between Bioimpedance Vector Displacement and Renal Function After a Marathon in Non-elite Runners
title_fullStr Relationship Between Bioimpedance Vector Displacement and Renal Function After a Marathon in Non-elite Runners
title_full_unstemmed Relationship Between Bioimpedance Vector Displacement and Renal Function After a Marathon in Non-elite Runners
title_sort Relationship Between Bioimpedance Vector Displacement and Renal Function After a Marathon in Non-elite Runners
dc.creator.none.fl_str_mv Nescolarde, Lexa|||0000-0001-6861-5106
Roca, Emma|||0000-0002-2338-5877
Bogónez-Franco, Paco|||0000-0002-5364-231X
Hernández-Hermoso, José
Bayés-Genís, Antoni|||0000-0002-3044-197X
Ara del Rey, Jordi|||0000-0002-7281-9969
author Nescolarde, Lexa|||0000-0001-6861-5106
author_facet Nescolarde, Lexa|||0000-0001-6861-5106
Roca, Emma|||0000-0002-2338-5877
Bogónez-Franco, Paco|||0000-0002-5364-231X
Hernández-Hermoso, José
Bayés-Genís, Antoni|||0000-0002-3044-197X
Ara del Rey, Jordi|||0000-0002-7281-9969
author_role author
author2 Roca, Emma|||0000-0002-2338-5877
Bogónez-Franco, Paco|||0000-0002-5364-231X
Hernández-Hermoso, José
Bayés-Genís, Antoni|||0000-0002-3044-197X
Ara del Rey, Jordi|||0000-0002-7281-9969
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Marathon race
BIVA
Serum creatinine
C-reactive protein
Serum creatine kinase
AKI stage 1
topic Marathon race
BIVA
Serum creatinine
C-reactive protein
Serum creatine kinase
AKI stage 1
description Purpose: This study investigates the relationship between whole-body bioimpedance vector displacement, using bioelectrical impedance vector analysis (BIVA), and renal function through serum biomarkers [creatinine, urea, sodium, C-reactive protein (CRP), and creatine kinase] and urine biomarkers after a marathon. Methods: Bioimpedance measurements were taken among 19 non-elite runners at 24 h pre-race, immediately post-race, and at 48 h post-race. The bioimpedance measurements were analyzed by BIVA using the Hotelling's T2 test. The runners were divided according to a cutoff of serum creatinine level immediately post-race in G1 (<1.2 mg/dl of serum creatinine level) and G2 (≥1.2 mg/dl of serum creatinine level). The increase of the serum creatinine levels in 83% of G2 runners was related to acute kidney injury (AKI) stage 1. Results: Neither G1 nor G2 showed a creatinine clearance rate (CCr) lower than 60 ml/min. G2 showed a significant increase in CRP values at 48 h post-race vs baseline compared to G1 (P < 0.05), with over 5 mg/L (6.8-15.2) in 92% of the runners, and in CK values with over 215 U/L (282-1,882) at 48 h post-race in 100% of the runners. By BIVA, the 95% confidence ellipses of G2 showed shorter bioimpedance vectors than G1, with a noticeable minor Xc/H (P < 0.01), indicating an expansion on extracellular water and inflammation. The runners with 48 h post-race Xc/H values ≤30.5 Ω, with a decrease from -3 to -12% with respect to the Xc/H value at 24 h pre-race, indicated AKI stage 1 with 85.7% sensitivity and 91.7% specificity, with a direct correlation between AKI stage 1 with greater CRP values at 48 h post-race and bioimpedance vector displacement, but not with CK values at 48 h post-race. Conclusion: Through this data collection, it was evidenced that a transient reduction in renal function is more related to inflammatory factors than muscle damage. The BIVA method along with serum biomarkers could be used to follow up the kidney function in runners.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/252620
https://dx.doi.org/urn:doi:10.3389/fphys.2020.00352
url https://ddd.uab.cat/record/252620
https://dx.doi.org/urn:doi:10.3389/fphys.2020.00352
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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