Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and mutation.

Liquid biopsies from cancer patients have the potential to improve diagnosis and prognosis. The assessment of surrogate markers of tumor progression in circulating extracellular vesicles could be a powerful non-invasive approach in this setting. We have characterized extracellular vesicles purified...

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Detalhes bibliográficos
Autores: García-Silva, Susana, Benito-Martín, Alberto, Sánchez-Redondo, Sara, Hernández-Barranco, Alberto, Ximénez-Embún, Pilar, Nogués, Laura, Mazariegos, Marina S, Brinkmann, Kay, Amor López, Ana, Meyer, Lisa, Rodríguez, Carlos, García-Martín, Carmen, Boskovic, Jasminka, Letón, Rocío, Montero, Cristina, Robledo Batanero, Mercedes, Santambrogio, Laura, Sue Brady, Mary, Szumera-Ciećkiewicz, Anna, Kalinowska, Iwona, Skog, Johan, Noerholm, Mikkel, Muñoz, Javier, Ortiz-Romero, Pablo L, Ruano, Yolanda, Rodríguez-Peralto, José L, Rutkowski, Piotr, Peinado Selgas, Hector
Formato: artículo
Fecha de publicación:2019
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/25958
Acesso em linha:https://hdl.handle.net/20.500.12105/25958
Access Level:acceso abierto
Palavra-chave:MUTANT KRAS
EXOXOME
DNA CELLS
Descrição
Resumo:Liquid biopsies from cancer patients have the potential to improve diagnosis and prognosis. The assessment of surrogate markers of tumor progression in circulating extracellular vesicles could be a powerful non-invasive approach in this setting. We have characterized extracellular vesicles purified from the lymphatic drainage also known as exudative seroma (ES) of stage III melanoma patients obtained after lymphadenectomy. Proteomic analysis showed that seroma-derived exosomes are enriched in proteins resembling melanoma progression. In addition, we found that the mutation can be detected in ES-derived extracellular vesicles and its detection correlated with patients at risk of relapse.

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