Transcriptional regulation of chemokine network by biologic monotherapy in ileum of patients with Crohn's disease

[Background]: Crohn’s disease (CD) exacerbation is marked by an intense cellular trafficking. We set out to determine the specific impact of biologic therapies on regulating chemokine network gene expression in healthy, mildly and severely inflamed tissue of CD patients.

Detalles Bibliográficos
Autores: Linares, Raquel, Gutiérrez, Ana, Marquez-Galera, Angel, Caparrós, Esther, Aparicio, José R., Madero, Lucía, Payá, Artemio, López-Atalaya, José P., Francés, Rubén
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/286363
Acceso en línea:http://hdl.handle.net/10261/286363
Access Level:acceso abierto
Palabra clave:Crohn’s disease
Inflammation
Chemokines
Biologic treatment
Descripción
Sumario:[Background]: Crohn’s disease (CD) exacerbation is marked by an intense cellular trafficking. We set out to determine the specific impact of biologic therapies on regulating chemokine network gene expression in healthy, mildly and severely inflamed tissue of CD patients.