Implicació de les neurotrofines en el desenvolupament i consolidació de les sinapsis neuromusculars
The loss of synaptic contacts is a phenomenon that it takes place in all the nervous system during the histogenesis of neural circuits. The initial synaptic superproduction comes followed by a synaptic contacts loss called synaptic elimination, given in the development period and also in the aging a...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2010 |
| País: | España |
| Institución: | Universitat Rovira i virgili (URV) |
| Repositorio: | Repositori Institucional de la Universitat Rovira i Virgili |
| OAI Identifier: | oai:urv.cat:TDX:1695 |
| Acceso en línea: | https://hdl.handle.net/20.500.11797/TDX1695 http://hdl.handle.net/10803/8751 |
| Access Level: | acceso abierto |
| Palabra clave: | 616.8 - Neurologia. Neuropatologia. Sistema nerviós 612 - Fisiologia 576 - Biologia cel·lular i subcel·lular. Citologia |
| Sumario: | The loss of synaptic contacts is a phenomenon that it takes place in all the nervous system during the histogenesis of neural circuits. The initial synaptic superproduction comes followed by a synaptic contacts loss called synaptic elimination, given in the development period and also in the aging and in some illnesses. Neurotrophins are essential proteins for the survival of the motorneuron and also can participate in other biological processes.With the neuromuscular model of rodents we investigate the neurotrophins location (BDNF, NT-3 and NT-4) and its receptors (TrkB, TrkC and p75NTR) and its involvement in the disconnection process and synaptic elimination in the postnatal period and in the local control of the cholinergic neurotransmission in the neonatal and adult neuromuscular junctions.The main results demonstrate that neurotrophins and its receptors are found in the cellular components of the neuromuscular junction and exert different effects in the ACh release and in the process of synaptic elimination. |
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