Obstetric complications and clinical presentation in first episode of psychosis

Valli, Isabel|||0000-0003-3052-7383; Garcia Rizo, Clemente|||0000-0002-4855-1608; Cuesta, M.; Vieta, Eduard|||0000-0002-0548-0053; Bioque, Miquel|||0000-0001-6887-7149; Lobo, Antonio|||0000-0002-9098-655X; González-Pinto, Ana|||0000-0002-2568-5179; Pina-Camacho, Laura|||0000-0003-1960-6443; Corripio, Iluminada|||0000-0003-2562-711X; Garriga, Marina|||0000-0001-7312-4969; Baeza, Inmaculada|||0000-0003-2611-5781; Martínez Sadurní, Laura|||0000-0001-8693-8902; Bitanihirwe, B.; Cannon, M.; Bernardo, Miquel|||0000-0001-8748-6717

Obstetric complications and clinical presentation in first episode of psychosis

Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disorders. We as...

Descripción completa

Detalles Bibliográficos
Autores:	Valli, Isabel\|\|\|0000-0003-3052-7383, Garcia Rizo, Clemente\|\|\|0000-0002-4855-1608, Cuesta, M., Vieta, Eduard\|\|\|0000-0002-0548-0053, Bioque, Miquel\|\|\|0000-0001-6887-7149, Lobo, Antonio\|\|\|0000-0002-9098-655X, González-Pinto, Ana\|\|\|0000-0002-2568-5179, Pina-Camacho, Laura\|\|\|0000-0003-1960-6443, Corripio, Iluminada\|\|\|0000-0003-2562-711X, Garriga, Marina\|\|\|0000-0001-7312-4969, Baeza, Inmaculada\|\|\|0000-0003-2611-5781, Martínez Sadurní, Laura\|\|\|0000-0001-8693-8902, Bitanihirwe, B., Cannon, M., Bernardo, Miquel\|\|\|0000-0001-8748-6717
Tipo de recurso:	artículo
Fecha de publicación:	2023
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:302807
Acceso en línea:	https://ddd.uab.cat/record/302807 https://dx.doi.org/urn:doi:10.1017/neu.2023.9
Access Level:	acceso abierto
Palabra clave:	First-episode psychosis Delivery Epiphenomena Obstetric complications Psychopathology

id	ES_9dfb2aa5dbebce160e5c5af774ecd4a5
oai_identifier_str	oai:ddd.uab.cat:302807
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Obstetric complications and clinical presentation in first episode of psychosisValli, Isabel\|\|\|0000-0003-3052-7383Garcia Rizo, Clemente\|\|\|0000-0002-4855-1608Cuesta, M.Vieta, Eduard\|\|\|0000-0002-0548-0053Bioque, Miquel\|\|\|0000-0001-6887-7149Lobo, Antonio\|\|\|0000-0002-9098-655XGonzález-Pinto, Ana\|\|\|0000-0002-2568-5179Pina-Camacho, Laura\|\|\|0000-0003-1960-6443Corripio, Iluminada\|\|\|0000-0003-2562-711XGarriga, Marina\|\|\|0000-0001-7312-4969Baeza, Inmaculada\|\|\|0000-0003-2611-5781Martínez Sadurní, Laura\|\|\|0000-0001-8693-8902Bitanihirwe, B.Cannon, M.Bernardo, Miquel\|\|\|0000-0001-8748-6717First-episode psychosisDeliveryEpiphenomenaObstetric complicationsPsychopathologyPsychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disorders. We assessed the clinical phenotypes of individuals with a first episode of psychosis (FEP) in relation to the presence of OCs. Two-hundred seventy-seven patients with an FEP were assessed for OCs using the Lewis-Murray scale, with data stratified into three subscales depending on the timing and the characteristics of the obstetric event, namely: complications of pregnancy, abnormal foetal growth and development and difficulties in delivery. We also considered other two groups: any complications during the pregnancy period and all OCs taken altogether. Patients were clinically evaluated with the Positive and Negative Syndrome Scale for schizophrenia. Total OCs and difficulties in delivery were related to more severe psychopathology, and this remained significant after co-varying for age, sex, traumatic experiences, antipsychotic dosage and cannabis use. Our results highlight the relevance of OCs for the clinical presentation of psychosis. Describing the timing of the OCs is essential in understanding the heterogeneity of the clinical presentation.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/302807https://dx.doi.org/urn:doi:10.1017/neu.2023.9reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/00325Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/00612Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00661open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3028072026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Obstetric complications and clinical presentation in first episode of psychosis
title	Obstetric complications and clinical presentation in first episode of psychosis
spellingShingle	Obstetric complications and clinical presentation in first episode of psychosis Valli, Isabel\|\|\|0000-0003-3052-7383 First-episode psychosis Delivery Epiphenomena Obstetric complications Psychopathology
title_short	Obstetric complications and clinical presentation in first episode of psychosis
title_full	Obstetric complications and clinical presentation in first episode of psychosis
title_fullStr	Obstetric complications and clinical presentation in first episode of psychosis
title_full_unstemmed	Obstetric complications and clinical presentation in first episode of psychosis
title_sort	Obstetric complications and clinical presentation in first episode of psychosis
dc.creator.none.fl_str_mv	Valli, Isabel\|\|\|0000-0003-3052-7383 Garcia Rizo, Clemente\|\|\|0000-0002-4855-1608 Cuesta, M. Vieta, Eduard\|\|\|0000-0002-0548-0053 Bioque, Miquel\|\|\|0000-0001-6887-7149 Lobo, Antonio\|\|\|0000-0002-9098-655X González-Pinto, Ana\|\|\|0000-0002-2568-5179 Pina-Camacho, Laura\|\|\|0000-0003-1960-6443 Corripio, Iluminada\|\|\|0000-0003-2562-711X Garriga, Marina\|\|\|0000-0001-7312-4969 Baeza, Inmaculada\|\|\|0000-0003-2611-5781 Martínez Sadurní, Laura\|\|\|0000-0001-8693-8902 Bitanihirwe, B. Cannon, M. Bernardo, Miquel\|\|\|0000-0001-8748-6717
author	Valli, Isabel\|\|\|0000-0003-3052-7383
author_facet	Valli, Isabel\|\|\|0000-0003-3052-7383 Garcia Rizo, Clemente\|\|\|0000-0002-4855-1608 Cuesta, M. Vieta, Eduard\|\|\|0000-0002-0548-0053 Bioque, Miquel\|\|\|0000-0001-6887-7149 Lobo, Antonio\|\|\|0000-0002-9098-655X González-Pinto, Ana\|\|\|0000-0002-2568-5179 Pina-Camacho, Laura\|\|\|0000-0003-1960-6443 Corripio, Iluminada\|\|\|0000-0003-2562-711X Garriga, Marina\|\|\|0000-0001-7312-4969 Baeza, Inmaculada\|\|\|0000-0003-2611-5781 Martínez Sadurní, Laura\|\|\|0000-0001-8693-8902 Bitanihirwe, B. Cannon, M. Bernardo, Miquel\|\|\|0000-0001-8748-6717
author_role	author
author2	Garcia Rizo, Clemente\|\|\|0000-0002-4855-1608 Cuesta, M. Vieta, Eduard\|\|\|0000-0002-0548-0053 Bioque, Miquel\|\|\|0000-0001-6887-7149 Lobo, Antonio\|\|\|0000-0002-9098-655X González-Pinto, Ana\|\|\|0000-0002-2568-5179 Pina-Camacho, Laura\|\|\|0000-0003-1960-6443 Corripio, Iluminada\|\|\|0000-0003-2562-711X Garriga, Marina\|\|\|0000-0001-7312-4969 Baeza, Inmaculada\|\|\|0000-0003-2611-5781 Martínez Sadurní, Laura\|\|\|0000-0001-8693-8902 Bitanihirwe, B. Cannon, M. Bernardo, Miquel\|\|\|0000-0001-8748-6717
author2_role	author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv	First-episode psychosis Delivery Epiphenomena Obstetric complications Psychopathology
topic	First-episode psychosis Delivery Epiphenomena Obstetric complications Psychopathology
description	Psychotic disorders exhibit a complex aetiology that combines genetic and environmental factors. Among the latter, obstetric complications (OCs) have been widely studied as risk factors, but it is not yet well understood how OCs relate to the heterogeneous presentations of psychotic disorders. We assessed the clinical phenotypes of individuals with a first episode of psychosis (FEP) in relation to the presence of OCs. Two-hundred seventy-seven patients with an FEP were assessed for OCs using the Lewis-Murray scale, with data stratified into three subscales depending on the timing and the characteristics of the obstetric event, namely: complications of pregnancy, abnormal foetal growth and development and difficulties in delivery. We also considered other two groups: any complications during the pregnancy period and all OCs taken altogether. Patients were clinically evaluated with the Positive and Negative Syndrome Scale for schizophrenia. Total OCs and difficulties in delivery were related to more severe psychopathology, and this remained significant after co-varying for age, sex, traumatic experiences, antipsychotic dosage and cannabis use. Our results highlight the relevance of OCs for the clinical presentation of psychosis. Describing the timing of the OCs is essential in understanding the heterogeneity of the clinical presentation.
publishDate	2023
dc.date.none.fl_str_mv	2 2023-01-01 2023 2023-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/302807 https://dx.doi.org/urn:doi:10.1017/neu.2023.9
url	https://ddd.uab.cat/record/302807 https://dx.doi.org/urn:doi:10.1017/neu.2023.9
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/00325 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/00612 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00661
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869414788037083136
score	15,812429

Obstetric complications and clinical presentation in first episode of psychosis

Similares en LA Referencia