Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis

Cano-Jiménez, Esteban; Vázquez Rodríguez, Tomás|||0000-0001-6718-5044; Martín-Robles, Irene; Castillo, Diego|||0000-0002-4862-3595; Juan García, Javier; Bollo de Miguel, Elena; Robles-Pérez, Alejandro; Ferrer Galván, Marta; Mouronte Roibas, Cecilia; Herrera Lara, Susana; Bermudo, Guadalupe|||0000-0002-2010-7679; García Moyano, Marta; Rodríguez Portal, Jose Antonio; Sellarés Torres, Jacobo; Narváez, Javier|||0000-0002-1614-8064; Molina Molina, Maria|||0000-0002-1852-1723

Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis

Rheumatoid arthritis (RA) is a systemic autoimmune disease whose main extra-articular organ affected is the lung, sometimes in the form of diffuse interstitial lung disease (ILD) and conditions the prognosis. A multicenter, observational, descriptive and cross-sectional study of consecutive patients...

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Autores:	Cano-Jiménez, Esteban, Vázquez Rodríguez, Tomás\|\|\|0000-0001-6718-5044, Martín-Robles, Irene, Castillo, Diego\|\|\|0000-0002-4862-3595, Juan García, Javier, Bollo de Miguel, Elena, Robles-Pérez, Alejandro, Ferrer Galván, Marta, Mouronte Roibas, Cecilia, Herrera Lara, Susana, Bermudo, Guadalupe\|\|\|0000-0002-2010-7679, García Moyano, Marta, Rodríguez Portal, Jose Antonio, Sellarés Torres, Jacobo, Narváez, Javier\|\|\|0000-0002-1614-8064, Molina Molina, Maria\|\|\|0000-0002-1852-1723
Tipo de recurso:	artículo
Fecha de publicación:	2021
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:271993
Acceso en línea:	https://ddd.uab.cat/record/271993 https://dx.doi.org/urn:doi:10.1038/s41598-021-88734-2
Access Level:	acceso abierto
Palabra clave:	Adult Aged Aged, 80 and over Antirheumatic Agents Arthritis, Rheumatoid Cross-Sectional Studies Delayed Diagnosis Female Humans Leflunomide Lung Diseases, Interstitial Male Methotrexate Middle Aged Respiratory Tract Infections Spain

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spelling	Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritisCano-Jiménez, EstebanVázquez Rodríguez, Tomás\|\|\|0000-0001-6718-5044Martín-Robles, IreneCastillo, Diego\|\|\|0000-0002-4862-3595Juan García, JavierBollo de Miguel, ElenaRobles-Pérez, AlejandroFerrer Galván, MartaMouronte Roibas, CeciliaHerrera Lara, SusanaBermudo, Guadalupe\|\|\|0000-0002-2010-7679García Moyano, MartaRodríguez Portal, Jose AntonioSellarés Torres, JacoboNarváez, Javier\|\|\|0000-0002-1614-8064Molina Molina, Maria\|\|\|0000-0002-1852-1723AdultAgedAged, 80 and overAntirheumatic AgentsArthritis, RheumatoidCross-Sectional StudiesDelayed DiagnosisFemaleHumansLeflunomideLung Diseases, InterstitialMaleMethotrexateMiddle AgedRespiratory Tract InfectionsSpainRheumatoid arthritis (RA) is a systemic autoimmune disease whose main extra-articular organ affected is the lung, sometimes in the form of diffuse interstitial lung disease (ILD) and conditions the prognosis. A multicenter, observational, descriptive and cross-sectional study of consecutive patients diagnosed with RA-ILD. Demographic, analytical, respiratory functional and evolution characteristics were analyzed to evaluate the predictors of progression and mortality. 106 patients were included. The multivariate analysis showed that the diagnostic delay was an independent predictor of mortality (HR 1.11, CI 1.01-1.23, p = 0.035). Also, age (HR 1.33, 95% CI 1.09-1.62, p = 0.0045), DLCO (%) (HR 0.85, 95% CI 0.73-0.98, p = 0.0246), and final SatO2 (%) in the 6MWT (HR 0.62, 95% CI 0.39-0.99, p = 0.0465) were independent predictor variables of mortality, as well as GAP index (HR 4.65, 95% CI 1.59-13.54, p = 0.0051) and CPI index (HR 1.12, 95% CI 1.03-1.22, p = 0.0092). The withdrawal of MTX or LFN after ILD diagnosis was associated with disease progression in the COX analysis (HR 2.18, 95% CI 1.14-4.18, p = 0.019). This is the first study that highlights the diagnostic delay in RA-ILD is associated with an increased mortality just like happens in IPF. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/271993https://dx.doi.org/urn:doi:10.1038/s41598-021-88734-2reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2719932026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis
title	Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis
spellingShingle	Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis Cano-Jiménez, Esteban Adult Aged Aged, 80 and over Antirheumatic Agents Arthritis, Rheumatoid Cross-Sectional Studies Delayed Diagnosis Female Humans Leflunomide Lung Diseases, Interstitial Male Methotrexate Middle Aged Respiratory Tract Infections Spain
title_short	Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis
title_full	Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis
title_fullStr	Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis
title_full_unstemmed	Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis
title_sort	Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis
dc.creator.none.fl_str_mv	Cano-Jiménez, Esteban Vázquez Rodríguez, Tomás\|\|\|0000-0001-6718-5044 Martín-Robles, Irene Castillo, Diego\|\|\|0000-0002-4862-3595 Juan García, Javier Bollo de Miguel, Elena Robles-Pérez, Alejandro Ferrer Galván, Marta Mouronte Roibas, Cecilia Herrera Lara, Susana Bermudo, Guadalupe\|\|\|0000-0002-2010-7679 García Moyano, Marta Rodríguez Portal, Jose Antonio Sellarés Torres, Jacobo Narváez, Javier\|\|\|0000-0002-1614-8064 Molina Molina, Maria\|\|\|0000-0002-1852-1723
author	Cano-Jiménez, Esteban
author_facet	Cano-Jiménez, Esteban Vázquez Rodríguez, Tomás\|\|\|0000-0001-6718-5044 Martín-Robles, Irene Castillo, Diego\|\|\|0000-0002-4862-3595 Juan García, Javier Bollo de Miguel, Elena Robles-Pérez, Alejandro Ferrer Galván, Marta Mouronte Roibas, Cecilia Herrera Lara, Susana Bermudo, Guadalupe\|\|\|0000-0002-2010-7679 García Moyano, Marta Rodríguez Portal, Jose Antonio Sellarés Torres, Jacobo Narváez, Javier\|\|\|0000-0002-1614-8064 Molina Molina, Maria\|\|\|0000-0002-1852-1723
author_role	author
author2	Vázquez Rodríguez, Tomás\|\|\|0000-0001-6718-5044 Martín-Robles, Irene Castillo, Diego\|\|\|0000-0002-4862-3595 Juan García, Javier Bollo de Miguel, Elena Robles-Pérez, Alejandro Ferrer Galván, Marta Mouronte Roibas, Cecilia Herrera Lara, Susana Bermudo, Guadalupe\|\|\|0000-0002-2010-7679 García Moyano, Marta Rodríguez Portal, Jose Antonio Sellarés Torres, Jacobo Narváez, Javier\|\|\|0000-0002-1614-8064 Molina Molina, Maria\|\|\|0000-0002-1852-1723
author2_role	author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Adult Aged Aged, 80 and over Antirheumatic Agents Arthritis, Rheumatoid Cross-Sectional Studies Delayed Diagnosis Female Humans Leflunomide Lung Diseases, Interstitial Male Methotrexate Middle Aged Respiratory Tract Infections Spain
topic	Adult Aged Aged, 80 and over Antirheumatic Agents Arthritis, Rheumatoid Cross-Sectional Studies Delayed Diagnosis Female Humans Leflunomide Lung Diseases, Interstitial Male Methotrexate Middle Aged Respiratory Tract Infections Spain
description	Rheumatoid arthritis (RA) is a systemic autoimmune disease whose main extra-articular organ affected is the lung, sometimes in the form of diffuse interstitial lung disease (ILD) and conditions the prognosis. A multicenter, observational, descriptive and cross-sectional study of consecutive patients diagnosed with RA-ILD. Demographic, analytical, respiratory functional and evolution characteristics were analyzed to evaluate the predictors of progression and mortality. 106 patients were included. The multivariate analysis showed that the diagnostic delay was an independent predictor of mortality (HR 1.11, CI 1.01-1.23, p = 0.035). Also, age (HR 1.33, 95% CI 1.09-1.62, p = 0.0045), DLCO (%) (HR 0.85, 95% CI 0.73-0.98, p = 0.0246), and final SatO2 (%) in the 6MWT (HR 0.62, 95% CI 0.39-0.99, p = 0.0465) were independent predictor variables of mortality, as well as GAP index (HR 4.65, 95% CI 1.59-13.54, p = 0.0051) and CPI index (HR 1.12, 95% CI 1.03-1.22, p = 0.0092). The withdrawal of MTX or LFN after ILD diagnosis was associated with disease progression in the COX analysis (HR 2.18, 95% CI 1.14-4.18, p = 0.019). This is the first study that highlights the diagnostic delay in RA-ILD is associated with an increased mortality just like happens in IPF.
publishDate	2021
dc.date.none.fl_str_mv	2 2021-01-01 2021 2021-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/271993 https://dx.doi.org/urn:doi:10.1038/s41598-021-88734-2
url	https://ddd.uab.cat/record/271993 https://dx.doi.org/urn:doi:10.1038/s41598-021-88734-2
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
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Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis

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