Human astrovirus outbreak in a daycare center and propagation among household contacts

first_pagesettings Open AccessArticle Human Astrovirus Outbreak in a Daycare Center and Propagation among Household Contacts by Ignacio Parrón 1,2,*ORCID,Elsa Plasencia 1,Thais Cornejo-Sánchez 3,Mireia Jané 2,4,5ORCID,Cristina Pérez 1,Conchita Izquierdo 4,Susana Guix 6,7ORCID,Àngela Domínguez 2,5ORC...

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Autores: Parrón Bernabé, Ignacio, Plasencia, Elsa, Cornejo Sánchez, Thais, Jané, Mireia, Pérez, Cristina, Izquierdo, Conchita, Guix Arnau, Susana, Domínguez García, Àngela, Working Group for the Study of Outbreaks of Acute
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/181125
Acesso em linha:https://hdl.handle.net/2445/181125
Access Level:Acceso aberto
Palavra-chave:Gastroenteritis
Virus
Viruses
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spelling Human astrovirus outbreak in a daycare center and propagation among household contactsParrón Bernabé, IgnacioPlasencia, ElsaCornejo Sánchez, ThaisJané, MireiaPérez, CristinaIzquierdo, ConchitaGuix Arnau, SusanaDomínguez García, ÀngelaWorking Group for the Study of Outbreaks of AcuteGastroenteritisVirusGastroenteritisVirusesfirst_pagesettings Open AccessArticle Human Astrovirus Outbreak in a Daycare Center and Propagation among Household Contacts by Ignacio Parrón 1,2,*ORCID,Elsa Plasencia 1,Thais Cornejo-Sánchez 3,Mireia Jané 2,4,5ORCID,Cristina Pérez 1,Conchita Izquierdo 4,Susana Guix 6,7ORCID,Àngela Domínguez 2,5ORCID andon behalf of the Working Group for the Study of Acute Gastroenteritis Outbreaks in Catalonia 1 Sub-Direcció Regional a Barcelona del Departament de Salut, 08005 Barcelona, Spain 2 Departament de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain 3 Departament de Microbiologia, Vall d'Hebrón Hospital, 08035 Barcelona, Spain 4 Sub-Direcció General de Vigilància i Resposta a Emergències de Salut Pública, 08005 Barcelona, Spain 5 CIBER Epidemiologia y Salud Pública, Instituto de Salud Carlos III, 28029 Madrid, Spain 6 Grup de Virus Entérics, Departament de Genètica Microbiologia i Estadística, Universitat de Barcelona, 08028 Barcelona, Spain 7 Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), Universitat de Barcelona, 08921 Santa Coloma de Gramenet, Spain * Author to whom correspondence should be addressed. Membership of the Working Group for the Study of Acute Gastroenteritis Outbreaks in Catalonia is provided in the Acknowledgments. Academic Editor: Stacey Schultz-Cherry Viruses 2021, 13(6), 1100; https://doi.org/10.3390/v13061100 Received: 2 May 2021 / Revised: 28 May 2021 / Accepted: 3 June 2021 / Published: 9 June 2021 (This article belongs to the Special Issue Gastroenteritis Viruses 2021) Download PDF Browse Figure Review Reports Citation Export Abstract We investigated an outbreak of acute gastroenteritis due to human astrovirus in a daycare center, describing the transmission mechanism, the most affected age groups, conditioning factors and the extent of the outbreak among household contacts of the daycare center attenders. Data were collected from persons exposed at the daycare center and their home contacts. Fecal samples from affected and non-affected daycare center attenders were analyzed for viruses causing acute gastroenteritis by RT-PCR. The percentage of households affected and the attack rates (AR) were calculated. The attack rates were compared using the rate ratio (RR) with 95% confidence intervals. Information was obtained from 245 people (76 attenders and 169 contacts) of whom 49 were clinical cases. Five HAstV-4, two HAstV-8 and three non-typable HAstV cases were identified (six from clinical cases and four from asymptomatic infected people). The global AR was 20% (41.2% in children aged < 2 years). Data were obtained from 67 households: 20 households of affected attenders and 47 of non-affected attendees. Household contacts of affected attenders had a higher AR (74.3%) than that of non-affected attendees (2.4%). We found asymptomatic infections amongst daycare attendees. The transmission of HAstV during the outbreak was not limited to the daycare center but extended to household contacts of both affected and non-affected attenders.MDPI2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/181125Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/v13061100Viruses, 2021, vol. 13https://doi.org/10.3390/v13061100cc-by (c) Parrón, Ignacio et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1811252026-05-29T05:05:01Z
dc.title.none.fl_str_mv Human astrovirus outbreak in a daycare center and propagation among household contacts
title Human astrovirus outbreak in a daycare center and propagation among household contacts
spellingShingle Human astrovirus outbreak in a daycare center and propagation among household contacts
Parrón Bernabé, Ignacio
Gastroenteritis
Virus
Gastroenteritis
Viruses
title_short Human astrovirus outbreak in a daycare center and propagation among household contacts
title_full Human astrovirus outbreak in a daycare center and propagation among household contacts
title_fullStr Human astrovirus outbreak in a daycare center and propagation among household contacts
title_full_unstemmed Human astrovirus outbreak in a daycare center and propagation among household contacts
title_sort Human astrovirus outbreak in a daycare center and propagation among household contacts
dc.creator.none.fl_str_mv Parrón Bernabé, Ignacio
Plasencia, Elsa
Cornejo Sánchez, Thais
Jané, Mireia
Pérez, Cristina
Izquierdo, Conchita
Guix Arnau, Susana
Domínguez García, Àngela
Working Group for the Study of Outbreaks of Acute
author Parrón Bernabé, Ignacio
author_facet Parrón Bernabé, Ignacio
Plasencia, Elsa
Cornejo Sánchez, Thais
Jané, Mireia
Pérez, Cristina
Izquierdo, Conchita
Guix Arnau, Susana
Domínguez García, Àngela
Working Group for the Study of Outbreaks of Acute
author_role author
author2 Plasencia, Elsa
Cornejo Sánchez, Thais
Jané, Mireia
Pérez, Cristina
Izquierdo, Conchita
Guix Arnau, Susana
Domínguez García, Àngela
Working Group for the Study of Outbreaks of Acute
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Gastroenteritis
Virus
Gastroenteritis
Viruses
topic Gastroenteritis
Virus
Gastroenteritis
Viruses
description first_pagesettings Open AccessArticle Human Astrovirus Outbreak in a Daycare Center and Propagation among Household Contacts by Ignacio Parrón 1,2,*ORCID,Elsa Plasencia 1,Thais Cornejo-Sánchez 3,Mireia Jané 2,4,5ORCID,Cristina Pérez 1,Conchita Izquierdo 4,Susana Guix 6,7ORCID,Àngela Domínguez 2,5ORCID andon behalf of the Working Group for the Study of Acute Gastroenteritis Outbreaks in Catalonia 1 Sub-Direcció Regional a Barcelona del Departament de Salut, 08005 Barcelona, Spain 2 Departament de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain 3 Departament de Microbiologia, Vall d'Hebrón Hospital, 08035 Barcelona, Spain 4 Sub-Direcció General de Vigilància i Resposta a Emergències de Salut Pública, 08005 Barcelona, Spain 5 CIBER Epidemiologia y Salud Pública, Instituto de Salud Carlos III, 28029 Madrid, Spain 6 Grup de Virus Entérics, Departament de Genètica Microbiologia i Estadística, Universitat de Barcelona, 08028 Barcelona, Spain 7 Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), Universitat de Barcelona, 08921 Santa Coloma de Gramenet, Spain * Author to whom correspondence should be addressed. Membership of the Working Group for the Study of Acute Gastroenteritis Outbreaks in Catalonia is provided in the Acknowledgments. Academic Editor: Stacey Schultz-Cherry Viruses 2021, 13(6), 1100; https://doi.org/10.3390/v13061100 Received: 2 May 2021 / Revised: 28 May 2021 / Accepted: 3 June 2021 / Published: 9 June 2021 (This article belongs to the Special Issue Gastroenteritis Viruses 2021) Download PDF Browse Figure Review Reports Citation Export Abstract We investigated an outbreak of acute gastroenteritis due to human astrovirus in a daycare center, describing the transmission mechanism, the most affected age groups, conditioning factors and the extent of the outbreak among household contacts of the daycare center attenders. Data were collected from persons exposed at the daycare center and their home contacts. Fecal samples from affected and non-affected daycare center attenders were analyzed for viruses causing acute gastroenteritis by RT-PCR. The percentage of households affected and the attack rates (AR) were calculated. The attack rates were compared using the rate ratio (RR) with 95% confidence intervals. Information was obtained from 245 people (76 attenders and 169 contacts) of whom 49 were clinical cases. Five HAstV-4, two HAstV-8 and three non-typable HAstV cases were identified (six from clinical cases and four from asymptomatic infected people). The global AR was 20% (41.2% in children aged < 2 years). Data were obtained from 67 households: 20 households of affected attenders and 47 of non-affected attendees. Household contacts of affected attenders had a higher AR (74.3%) than that of non-affected attendees (2.4%). We found asymptomatic infections amongst daycare attendees. The transmission of HAstV during the outbreak was not limited to the daycare center but extended to household contacts of both affected and non-affected attenders.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/181125
url https://hdl.handle.net/2445/181125
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/v13061100
Viruses, 2021, vol. 13
https://doi.org/10.3390/v13061100
dc.rights.none.fl_str_mv cc-by (c) Parrón, Ignacio et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Parrón, Ignacio et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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