Levofloxacin treatment failure in Haemophilus influenzae pneumonia.

We describe the first case of failure of oral levofloxacin treatment of community-acquired pneumonia caused by Haemophilus influenzae. The strain showed cross-resistance to fluoroquinolones and carried four mutations in quinolone resistance-determining regions of DNA gyrase and topoisomerase IV gene...

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Detalles Bibliográficos
Autores: Bastida, Teresa, Perez-Vazquez, Maria, Campos, Jose, Cortés-Lletget, María Cristina, Roman, Federico, Tubau, Fe, de la Campa, Adela G, Alonso-Tarrés, Carles
Tipo de recurso: artículo
Fecha de publicación:2003
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/12781
Acceso en línea:http://hdl.handle.net/20.500.12105/12781
Access Level:acceso abierto
Palabra clave:Levofloxacin
Aged
Anti-Infective Agents
Community-Acquired Infections
DNA Gyrase
Electrophoresis, Gel, Pulsed-Field
Fatal Outcome
Female
Haemophilus Infections
Haemophilus influenzae
Humans
Molecular Sequence Data
Ofloxacin
Pneumonia
Treatment Failure
Descripción
Sumario:We describe the first case of failure of oral levofloxacin treatment of community-acquired pneumonia caused by Haemophilus influenzae. The strain showed cross-resistance to fluoroquinolones and carried four mutations in quinolone resistance-determining regions of DNA gyrase and topoisomerase IV genes.

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