Implication of intestinal microbiota in the etiopathogenesis of fibromyalgia: A systematic review

Fibromyalgia (FM) is a highly prevalent chronic disease. About 4.7% of the world's population suffers from generalized pain and hypersensitivity, in addition to a wide range of physical and psychological symptoms. The etiopathogenesis of this disease is multifactorial, which makes its diagnosis...

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Autores: Palma-Ordóñez, Juan Francisco, Moreno-Fernández, Ana María, Ramírez-Tejero, Jorge Antolín, Durán-González, Elena, Martínez-Lara, Antonio, Cotán, David
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/171353
Acceso en línea:https://hdl.handle.net/11441/171353
https://doi.org/10.1111/1756-185X.15021
Access Level:acceso abierto
Palabra clave:Etiopathogenesis
Fibromyalgia
Gut Microbiota
Gut–brain axis
Metabolome
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spelling Implication of intestinal microbiota in the etiopathogenesis of fibromyalgia: A systematic reviewPalma-Ordóñez, Juan FranciscoMoreno-Fernández, Ana MaríaRamírez-Tejero, Jorge AntolínDurán-González, ElenaMartínez-Lara, AntonioCotán, DavidEtiopathogenesisFibromyalgiaGut MicrobiotaGut–brain axisMetabolomeFibromyalgia (FM) is a highly prevalent chronic disease. About 4.7% of the world's population suffers from generalized pain and hypersensitivity, in addition to a wide range of physical and psychological symptoms. The etiopathogenesis of this disease is multifactorial, which makes its diagnosis and treatment challenging. Recently, the increase in the number of studies on microbiota has provided new data that can help to understand the onset and development of FM. An updated systematic review of the causes of FM has been carried out in this work. Particularly in the last decade, research has focused on the gut–brain axis, which has emerged as a crucial mechanism for microbiota-host crosstalk. In FM patients, quantitative imbalances of the intestinal microbiota (dysbiosis) and bacterial metabolites with differential relative abundance have been found, especially short-chain fatty acids and lipopolysaccharides. Furthermore, the microbiota has been found to indirectly influence host neurotransmitter mechanisms, mainly through the serotonin precursor, glutamate, and gamma-aminobutyric acid. Thus, all these mechanisms and their influence on the etiopathogenesis of FM are discussed in this review.WileyCitología e Histología Normal y PatológicaCTS949: Biopatología y Estrés Oxidativo2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/171353https://doi.org/10.1111/1756-185X.15021reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésInternational Journal of Rheumatic Diseases, 27 (1), e15021.https://onlinelibrary.wiley.com/doi/10.1111/1756-185X.15021info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1713532026-06-17T12:51:07Z
dc.title.none.fl_str_mv Implication of intestinal microbiota in the etiopathogenesis of fibromyalgia: A systematic review
title Implication of intestinal microbiota in the etiopathogenesis of fibromyalgia: A systematic review
spellingShingle Implication of intestinal microbiota in the etiopathogenesis of fibromyalgia: A systematic review
Palma-Ordóñez, Juan Francisco
Etiopathogenesis
Fibromyalgia
Gut Microbiota
Gut–brain axis
Metabolome
title_short Implication of intestinal microbiota in the etiopathogenesis of fibromyalgia: A systematic review
title_full Implication of intestinal microbiota in the etiopathogenesis of fibromyalgia: A systematic review
title_fullStr Implication of intestinal microbiota in the etiopathogenesis of fibromyalgia: A systematic review
title_full_unstemmed Implication of intestinal microbiota in the etiopathogenesis of fibromyalgia: A systematic review
title_sort Implication of intestinal microbiota in the etiopathogenesis of fibromyalgia: A systematic review
dc.creator.none.fl_str_mv Palma-Ordóñez, Juan Francisco
Moreno-Fernández, Ana María
Ramírez-Tejero, Jorge Antolín
Durán-González, Elena
Martínez-Lara, Antonio
Cotán, David
author Palma-Ordóñez, Juan Francisco
author_facet Palma-Ordóñez, Juan Francisco
Moreno-Fernández, Ana María
Ramírez-Tejero, Jorge Antolín
Durán-González, Elena
Martínez-Lara, Antonio
Cotán, David
author_role author
author2 Moreno-Fernández, Ana María
Ramírez-Tejero, Jorge Antolín
Durán-González, Elena
Martínez-Lara, Antonio
Cotán, David
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Citología e Histología Normal y Patológica
CTS949: Biopatología y Estrés Oxidativo
dc.subject.none.fl_str_mv Etiopathogenesis
Fibromyalgia
Gut Microbiota
Gut–brain axis
Metabolome
topic Etiopathogenesis
Fibromyalgia
Gut Microbiota
Gut–brain axis
Metabolome
description Fibromyalgia (FM) is a highly prevalent chronic disease. About 4.7% of the world's population suffers from generalized pain and hypersensitivity, in addition to a wide range of physical and psychological symptoms. The etiopathogenesis of this disease is multifactorial, which makes its diagnosis and treatment challenging. Recently, the increase in the number of studies on microbiota has provided new data that can help to understand the onset and development of FM. An updated systematic review of the causes of FM has been carried out in this work. Particularly in the last decade, research has focused on the gut–brain axis, which has emerged as a crucial mechanism for microbiota-host crosstalk. In FM patients, quantitative imbalances of the intestinal microbiota (dysbiosis) and bacterial metabolites with differential relative abundance have been found, especially short-chain fatty acids and lipopolysaccharides. Furthermore, the microbiota has been found to indirectly influence host neurotransmitter mechanisms, mainly through the serotonin precursor, glutamate, and gamma-aminobutyric acid. Thus, all these mechanisms and their influence on the etiopathogenesis of FM are discussed in this review.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/171353
https://doi.org/10.1111/1756-185X.15021
url https://hdl.handle.net/11441/171353
https://doi.org/10.1111/1756-185X.15021
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Rheumatic Diseases, 27 (1), e15021.
https://onlinelibrary.wiley.com/doi/10.1111/1756-185X.15021
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
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