Using gold nanoparticles to detect single-nucleotide polymorphisms: Toward liquid biopsy

The possibility of detecting genetic mutations rapidly in physiological media through liquid biopsy has attracted the attention within the materials science community. The physical properties of nanoparticles combined with robust transduction methods ensure an improved sensitivity and specificity of...

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Detalles Bibliográficos
Autores: Sanromán Iglesias, María, Grzelczak, Marek
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/224997
Acceso en línea:http://hdl.handle.net/10261/224997
Access Level:acceso abierto
Palabra clave:Amplification reactions
Biomarkers
Colorimetric biosensing
Gold nanoparticles
Plasmonics
Single-point mutation
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spelling Using gold nanoparticles to detect single-nucleotide polymorphisms: Toward liquid biopsySanromán Iglesias, MaríaGrzelczak, MarekAmplification reactionsBiomarkersColorimetric biosensingGold nanoparticlesPlasmonicsSingle-point mutationThe possibility of detecting genetic mutations rapidly in physiological media through liquid biopsy has attracted the attention within the materials science community. The physical properties of nanoparticles combined with robust transduction methods ensure an improved sensitivity and specificity of a given assay and its implementation into point-of-care devices for common use. Covering the last twenty years, this review gives an overview of the state-of-the-art of the research on the use of gold nanoparticles in the development of colorimetric biosensors for the detection of single-nucleotide polymorphism as cancer biomarker. We discuss the main mechanisms of the assays that either are assisted by DNA-based molecular machines or by enzymatic reactions, summarize their performance and provide an outlook towards future developments.National Center for Biotechnology InformationConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2020202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/224997reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3762/bjnano.20Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2249972026-05-22T06:33:51Z
dc.title.none.fl_str_mv Using gold nanoparticles to detect single-nucleotide polymorphisms: Toward liquid biopsy
title Using gold nanoparticles to detect single-nucleotide polymorphisms: Toward liquid biopsy
spellingShingle Using gold nanoparticles to detect single-nucleotide polymorphisms: Toward liquid biopsy
Sanromán Iglesias, María
Amplification reactions
Biomarkers
Colorimetric biosensing
Gold nanoparticles
Plasmonics
Single-point mutation
title_short Using gold nanoparticles to detect single-nucleotide polymorphisms: Toward liquid biopsy
title_full Using gold nanoparticles to detect single-nucleotide polymorphisms: Toward liquid biopsy
title_fullStr Using gold nanoparticles to detect single-nucleotide polymorphisms: Toward liquid biopsy
title_full_unstemmed Using gold nanoparticles to detect single-nucleotide polymorphisms: Toward liquid biopsy
title_sort Using gold nanoparticles to detect single-nucleotide polymorphisms: Toward liquid biopsy
dc.creator.none.fl_str_mv Sanromán Iglesias, María
Grzelczak, Marek
author Sanromán Iglesias, María
author_facet Sanromán Iglesias, María
Grzelczak, Marek
author_role author
author2 Grzelczak, Marek
author2_role author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Amplification reactions
Biomarkers
Colorimetric biosensing
Gold nanoparticles
Plasmonics
Single-point mutation
topic Amplification reactions
Biomarkers
Colorimetric biosensing
Gold nanoparticles
Plasmonics
Single-point mutation
description The possibility of detecting genetic mutations rapidly in physiological media through liquid biopsy has attracted the attention within the materials science community. The physical properties of nanoparticles combined with robust transduction methods ensure an improved sensitivity and specificity of a given assay and its implementation into point-of-care devices for common use. Covering the last twenty years, this review gives an overview of the state-of-the-art of the research on the use of gold nanoparticles in the development of colorimetric biosensors for the detection of single-nucleotide polymorphism as cancer biomarker. We discuss the main mechanisms of the assays that either are assisted by DNA-based molecular machines or by enzymatic reactions, summarize their performance and provide an outlook towards future developments.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/224997
url http://hdl.handle.net/10261/224997
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3762/bjnano.20
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv National Center for Biotechnology Information
publisher.none.fl_str_mv National Center for Biotechnology Information
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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