Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: A systematic review

Producción Científica

Detalles Bibliográficos
Autores: Fernández Lázaro, Diego, Mielgo Ayuso, Juan Francisco, Seco Calvo, Jesús, Córdova Martínez, Alfredo, Caballero García, Alberto, Fernández Lázaro, César Ignacio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/52590
Acceso en línea:https://doi.org/10.3390/nu12020501
https://uvadoc.uva.es/handle/10324/52590
Access Level:acceso abierto
Palabra clave:Polyphenols
Polifenoles
Curcumin
Curcumina
Muscle damage
Daño muscular
Antioxidants
Antioxidantes
32 Ciencias Médicas
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spelling Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: A systematic reviewFernández Lázaro, DiegoMielgo Ayuso, Juan FranciscoSeco Calvo, JesúsCórdova Martínez, AlfredoCaballero García, AlbertoFernández Lázaro, César IgnacioPolyphenolsPolifenolesCurcuminCurcuminaMuscle damageDaño muscularAntioxidantsAntioxidantes32 Ciencias MédicasProducción CientíficaPhysical activity, particularly high-intensity eccentric muscle contractions, produces exercise-induced muscle damage (EIMD). The breakdown of muscle fibers and the consequent inflammatory responses derived from EIMD affect exercise performance. Curcumin, a natural polyphenol extracted from turmeric, has been shown to have mainly antioxidant and also anti-inflammatory properties. This effect of curcumin could improve EIMD and exercise performance. The main objective of this systematic review was to critically evaluate the effectiveness of curcumin supplementation on EIMD and inflammatory and oxidative markers in a physically active population. A structured search was carried out following Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines in the databases SCOPUS, Web of Science (WOS), and Medline (PubMed) from inception to October 2019. The search included original articles with randomized controlled crossover or parallel design in which the intake of curcumin administered before and/or after exercise was compared with an identical placebo situation. No filters were applied to the type of physical exercise performed, the sex or the age of the participants. Of the 301 articles identified in the search, 11 met the established criteria and were included in this systematic review. The methodological quality of the studies was assessed using the McMaster Critical Review Form. The use of curcumin reduces the subjective perception of the intensity of muscle pain; reduces muscle damage through the decrease of creatine kinase (CK); increases muscle performance; has an anti-inflammatory effect by modulating the pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-8; and may have a slight antioxidant effect. In summary, the administration of curcumin at a dose between 150–1500 mg/day before and during exercise, and up until 72 h’ post-exercise, improved performance by reducing EIMD and modulating the inflammation caused by physical activity. In addition, humans appear to be able to tolerate high doses of curcumin without significant side-effects.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/nu12020501https://uvadoc.uva.es/handle/10324/52590reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.mdpi.com/2072-6643/12/2/501info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:uvadoc.uva.es:10324/525902026-06-13T12:44:47Z
dc.title.none.fl_str_mv Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: A systematic review
title Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: A systematic review
spellingShingle Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: A systematic review
Fernández Lázaro, Diego
Polyphenols
Polifenoles
Curcumin
Curcumina
Muscle damage
Daño muscular
Antioxidants
Antioxidantes
32 Ciencias Médicas
title_short Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: A systematic review
title_full Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: A systematic review
title_fullStr Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: A systematic review
title_full_unstemmed Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: A systematic review
title_sort Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: A systematic review
dc.creator.none.fl_str_mv Fernández Lázaro, Diego
Mielgo Ayuso, Juan Francisco
Seco Calvo, Jesús
Córdova Martínez, Alfredo
Caballero García, Alberto
Fernández Lázaro, César Ignacio
author Fernández Lázaro, Diego
author_facet Fernández Lázaro, Diego
Mielgo Ayuso, Juan Francisco
Seco Calvo, Jesús
Córdova Martínez, Alfredo
Caballero García, Alberto
Fernández Lázaro, César Ignacio
author_role author
author2 Mielgo Ayuso, Juan Francisco
Seco Calvo, Jesús
Córdova Martínez, Alfredo
Caballero García, Alberto
Fernández Lázaro, César Ignacio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Polyphenols
Polifenoles
Curcumin
Curcumina
Muscle damage
Daño muscular
Antioxidants
Antioxidantes
32 Ciencias Médicas
topic Polyphenols
Polifenoles
Curcumin
Curcumina
Muscle damage
Daño muscular
Antioxidants
Antioxidantes
32 Ciencias Médicas
description Producción Científica
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/nu12020501
https://uvadoc.uva.es/handle/10324/52590
url https://doi.org/10.3390/nu12020501
https://uvadoc.uva.es/handle/10324/52590
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.mdpi.com/2072-6643/12/2/501
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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