Long telomeres are associated with clonality in wild populations of the fissiparous starfish Coscinasterias tenuispina

elomeres usually shorten during an organism's lifespan and have thus been used as an aging and health marker. When telomeres become sufficiently short, senescence is induced. The most common method of restoring telomere length is via telomerase reverse transcriptase activity, highly expressed d...

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Autores: Garcia-Cisneros, Alex, Pérez Portela, Rocío, Almrothc, Bethanie Carney, Degermand, Sofie, Palacín Cabañas, Cruz, Nilsson Skölde, Helen
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/173549
Acceso en línea:https://hdl.handle.net/2445/173549
Access Level:acceso abierto
Palabra clave:Estrelles de mar
Seqüència de nucleòtids
Starfishes
Nucleotide sequence
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spelling Long telomeres are associated with clonality in wild populations of the fissiparous starfish Coscinasterias tenuispinaGarcia-Cisneros, AlexPérez Portela, RocíoAlmrothc, Bethanie CarneyDegermand, SofiePalacín Cabañas, CruzNilsson Skölde, HelenEstrelles de marSeqüència de nucleòtidsStarfishesNucleotide sequenceelomeres usually shorten during an organism's lifespan and have thus been used as an aging and health marker. When telomeres become sufficiently short, senescence is induced. The most common method of restoring telomere length is via telomerase reverse transcriptase activity, highly expressed during embryogenesis. However, although asexual reproduction from adult tissues has an important role in the life cycles of certain species, its effect on the aging and fitness of wild populations, as well as its implications for the long-term survival of populations with limited genetic variation, is largely unknown. Here we compare relative telomere length of 58 individuals from four populations of the asexually reproducing starfish Coscinasterias tenuispina. Additionally, 12 individuals were used to compare telomere lengths in regenerating and non-regenerating arms, in two different tissues (tube feet and pyloric cecum). The level of clonality was assessed by genotyping the populations based on 12 specific microsatellite loci and relative telomere length was measured via quantitative PCR. The results revealed significantly longer telomeres in Mediterranean populations than Atlantic ones as demonstrated by the Kruskal-Wallis test (K=24.17, significant value: P-value<0.001), with the former also characterized by higher levels of clonality derived from asexual reproduction. Telomeres were furthermore significantly longer in regenerating arms than in non-regenerating arms within individuals (pyloric cecum tissue: Mann-Whitney test, V=299, P-value<10−6; and tube feet tissue Student's t=2.28, P-value=0.029). Our study suggests that one of the mechanisms responsible for the long-term somatic maintenance and persistence of clonal populations is telomere elongation.The Genetics Society2021202120152021info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion7 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/173549Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1038/hdy.2015.43Heredity, 2015, vol. 115, p. 437-443https://doi.org/10.1038/hdy.2015.43(c) Macmillan Publishers Limited, 2015info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1735492026-05-29T05:05:01Z
dc.title.none.fl_str_mv Long telomeres are associated with clonality in wild populations of the fissiparous starfish Coscinasterias tenuispina
title Long telomeres are associated with clonality in wild populations of the fissiparous starfish Coscinasterias tenuispina
spellingShingle Long telomeres are associated with clonality in wild populations of the fissiparous starfish Coscinasterias tenuispina
Garcia-Cisneros, Alex
Estrelles de mar
Seqüència de nucleòtids
Starfishes
Nucleotide sequence
title_short Long telomeres are associated with clonality in wild populations of the fissiparous starfish Coscinasterias tenuispina
title_full Long telomeres are associated with clonality in wild populations of the fissiparous starfish Coscinasterias tenuispina
title_fullStr Long telomeres are associated with clonality in wild populations of the fissiparous starfish Coscinasterias tenuispina
title_full_unstemmed Long telomeres are associated with clonality in wild populations of the fissiparous starfish Coscinasterias tenuispina
title_sort Long telomeres are associated with clonality in wild populations of the fissiparous starfish Coscinasterias tenuispina
dc.creator.none.fl_str_mv Garcia-Cisneros, Alex
Pérez Portela, Rocío
Almrothc, Bethanie Carney
Degermand, Sofie
Palacín Cabañas, Cruz
Nilsson Skölde, Helen
author Garcia-Cisneros, Alex
author_facet Garcia-Cisneros, Alex
Pérez Portela, Rocío
Almrothc, Bethanie Carney
Degermand, Sofie
Palacín Cabañas, Cruz
Nilsson Skölde, Helen
author_role author
author2 Pérez Portela, Rocío
Almrothc, Bethanie Carney
Degermand, Sofie
Palacín Cabañas, Cruz
Nilsson Skölde, Helen
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Estrelles de mar
Seqüència de nucleòtids
Starfishes
Nucleotide sequence
topic Estrelles de mar
Seqüència de nucleòtids
Starfishes
Nucleotide sequence
description elomeres usually shorten during an organism's lifespan and have thus been used as an aging and health marker. When telomeres become sufficiently short, senescence is induced. The most common method of restoring telomere length is via telomerase reverse transcriptase activity, highly expressed during embryogenesis. However, although asexual reproduction from adult tissues has an important role in the life cycles of certain species, its effect on the aging and fitness of wild populations, as well as its implications for the long-term survival of populations with limited genetic variation, is largely unknown. Here we compare relative telomere length of 58 individuals from four populations of the asexually reproducing starfish Coscinasterias tenuispina. Additionally, 12 individuals were used to compare telomere lengths in regenerating and non-regenerating arms, in two different tissues (tube feet and pyloric cecum). The level of clonality was assessed by genotyping the populations based on 12 specific microsatellite loci and relative telomere length was measured via quantitative PCR. The results revealed significantly longer telomeres in Mediterranean populations than Atlantic ones as demonstrated by the Kruskal-Wallis test (K=24.17, significant value: P-value<0.001), with the former also characterized by higher levels of clonality derived from asexual reproduction. Telomeres were furthermore significantly longer in regenerating arms than in non-regenerating arms within individuals (pyloric cecum tissue: Mann-Whitney test, V=299, P-value<10−6; and tube feet tissue Student's t=2.28, P-value=0.029). Our study suggests that one of the mechanisms responsible for the long-term somatic maintenance and persistence of clonal populations is telomere elongation.
publishDate 2015
dc.date.none.fl_str_mv 2015
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/173549
url https://hdl.handle.net/2445/173549
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1038/hdy.2015.43
Heredity, 2015, vol. 115, p. 437-443
https://doi.org/10.1038/hdy.2015.43
dc.rights.none.fl_str_mv (c) Macmillan Publishers Limited, 2015
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Macmillan Publishers Limited, 2015
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv The Genetics Society
publisher.none.fl_str_mv The Genetics Society
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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