Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

BackgroundPrevious studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. MethodsProspective, observational, multicenter study comparing cohorts of IBD patients f...

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Detalhes bibliográficos
Autores: Gutiérrez, Ana, Zapater, Pedro, Ricart, Elena, González Vivó, María, Gordillo, Jordi, Olivares Berjaga, David, Vera, Isabel, Mañosa, Míriam, Gisbert, Javier P., Aguas, Mariam, Sánchez Rodríguez, Eugenia, Boscá Watts, Maia, Laredo, Viviana, Camps, Blau, Marín Jiménez, Ignacio, Zabana Abdo, Yamile, Martín Arranz, María Dolores, Muñoz, Roser, Navarro, Mercè, Sierra, Eva, Madero Velázquez, Lucía, Vela, Milagros, Pérez Calle, José Lázaro, Sainz Arnau, Empar, Calvet, Xavier, Arias, Lara, Morales, Victor, Bermejo, Fernando, Fernández Salazar, Luis, Domselaar, Manuel van, Castro, Luisa de, Rodríguez, Cristina, Muñoz Villafranca, Carmen, Lorente, Rufo, Rivero, Montserrat, Iglesias, Eva, Herreros, Belén, Busquets, David, Riera, Joan, Martínez Montiel, María Pilar, Roldón, Marta, Roncero, Oscar, Hinojosa, Esther, Sierra, Mónica, Barrio, Jesús, Francisco, Ruth de, Huguet, José María, Merino, Olga, Carpio, Daniel, Ginard, Daniel, Muñoz, Fernando, Piqueras, Marta, Almela, Pedro, Argüelles Arias, Federico, Alcaín, Guillermo, Bujanda, Luis, Manceñido, Noemí, Lucendo, Alfredo J., Varela, Pilar, Rodríguez Lago, Iago, Ramos, Laura, Sempere, Laura, Sesé, Eva, Barreiro de Acosta, Manuel, Domènech, Eugeni, Francés, Rubén
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/183759
Acesso em linha:https://hdl.handle.net/2445/183759
Access Level:acceso abierto
Palavra-chave:Malalties inflamatòries intestinals
Fenotip
Inflammatory bowel diseases
Phenotype
Descrição
Resumo:BackgroundPrevious studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. MethodsProspective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. ResultsWe included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 +/- 12 vs. 54 +/- 16 years, p < 0.001), had been diagnosed younger (31 +/- 12 vs. 36 +/- 15 years, p < 0.001), and had a shorter disease duration (14 +/- 7 vs. 18 +/- 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92-2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0-1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. ConclusionsCompared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.

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