The A640G CYBA polymorphism associates with subclinical atherosclerosis in diabetes
Oxidative stress is implicated in diabetes. The NADPH oxidases are the main source of superoxide in phagocytic and vascular cells, and p22phox is a key subunit. Genetic variants of CYBA, the human p22phox gene, associate with cardiovascular disease. We investigated the association of the A640G polym...
| Autores: | , , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Data de publicação: | 2011 |
| País: | España |
| Recursos: | Universidad de Navarra |
| Repositório: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglês |
| OAI Identifier: | oai:dadun.unav.edu:10171/17937 |
| Acesso em linha: | https://hdl.handle.net/10171/17937 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Atherosclerosis Diabetes Intima-Media Thickness NADPH oxidase Oxidative stress A640G polymorphism |
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The A640G CYBA polymorphism associates with subclinical atherosclerosis in diabetesMoreno-Zulategui, M.U. (María de Ujue)|||/items/c970940e-b812-4c54-b9ee-26a5e0b78ec7San-José-Enériz, G. (Gorka)|||/items/362ac8c3-5d50-4383-9fc1-7abbed048387Fortuño, A. (Ana)|||/items/2324831f-71b3-4d1b-afc1-594e4e1bc0c9Miguel-Carrasco, J.L. (José Luis)|||/items/626cda34-5a0d-43e1-a34e-33d5f8c77fa6Beloqui, O. (Óscar)|||/items/87d04a14-2d74-4221-8a57-12550777420dDiez-Martinez, J. (Javier)|||/items/4f3a0e43-12bf-403d-9dc7-31fab0d11d41Zalba-Goñi, G. (Guillermo)|||/items/71410fa2-baa5-4efc-bce7-14b4b0e23802AtherosclerosisDiabetesIntima-Media ThicknessNADPH oxidaseOxidative stressA640G polymorphismOxidative stress is implicated in diabetes. The NADPH oxidases are the main source of superoxide in phagocytic and vascular cells, and p22phox is a key subunit. Genetic variants of CYBA, the human p22phox gene, associate with cardiovascular disease. We investigated the association of the A640G polymorphism with diabetes and its impact on phagocytic NADPH oxidase-dependent superoxide production and subclinical atherosclerosis. We studied 1212 subjects in which clinical parameters including carotid intima-media thickness (cIMT) were assessed. The A640G polymorphism was genotyped by TaqMan probes. In 496 subjects, the NADPH oxidase-dependent superoxide production in peripheral blood mononuclear cells was assessed by chemiluminescence. The GG genotype prevalence was significantly higher in type 2 diabetic patients than in non-diabetic subjects. Peripheral blood mononuclear cells from diabetic GG patients presented higher NADPH oxidase-dependent superoxide production than those of diabetic AA/AG patients. Within the diabetic group, GG patients presented higher cIMT levels than AA/AG patients. The A640G CYBA polymorphism may be a marker of oxidative stress risk and may be indicative of subclinical atherosclerosis in type 2 diabetes.Frontiers in BioscienceDadun. Depósito Académico Digital Universidad de Navarra20112011-05-1620112011-01-0120112011-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/17937reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/179372026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
The A640G CYBA polymorphism associates with subclinical atherosclerosis in diabetes |
| title |
The A640G CYBA polymorphism associates with subclinical atherosclerosis in diabetes |
| spellingShingle |
The A640G CYBA polymorphism associates with subclinical atherosclerosis in diabetes Moreno-Zulategui, M.U. (María de Ujue)|||/items/c970940e-b812-4c54-b9ee-26a5e0b78ec7 Atherosclerosis Diabetes Intima-Media Thickness NADPH oxidase Oxidative stress A640G polymorphism |
| title_short |
The A640G CYBA polymorphism associates with subclinical atherosclerosis in diabetes |
| title_full |
The A640G CYBA polymorphism associates with subclinical atherosclerosis in diabetes |
| title_fullStr |
The A640G CYBA polymorphism associates with subclinical atherosclerosis in diabetes |
| title_full_unstemmed |
The A640G CYBA polymorphism associates with subclinical atherosclerosis in diabetes |
| title_sort |
The A640G CYBA polymorphism associates with subclinical atherosclerosis in diabetes |
| dc.creator.none.fl_str_mv |
Moreno-Zulategui, M.U. (María de Ujue)|||/items/c970940e-b812-4c54-b9ee-26a5e0b78ec7 San-José-Enériz, G. (Gorka)|||/items/362ac8c3-5d50-4383-9fc1-7abbed048387 Fortuño, A. (Ana)|||/items/2324831f-71b3-4d1b-afc1-594e4e1bc0c9 Miguel-Carrasco, J.L. (José Luis)|||/items/626cda34-5a0d-43e1-a34e-33d5f8c77fa6 Beloqui, O. (Óscar)|||/items/87d04a14-2d74-4221-8a57-12550777420d Diez-Martinez, J. (Javier)|||/items/4f3a0e43-12bf-403d-9dc7-31fab0d11d41 Zalba-Goñi, G. (Guillermo)|||/items/71410fa2-baa5-4efc-bce7-14b4b0e23802 |
| author |
Moreno-Zulategui, M.U. (María de Ujue)|||/items/c970940e-b812-4c54-b9ee-26a5e0b78ec7 |
| author_facet |
Moreno-Zulategui, M.U. (María de Ujue)|||/items/c970940e-b812-4c54-b9ee-26a5e0b78ec7 San-José-Enériz, G. (Gorka)|||/items/362ac8c3-5d50-4383-9fc1-7abbed048387 Fortuño, A. (Ana)|||/items/2324831f-71b3-4d1b-afc1-594e4e1bc0c9 Miguel-Carrasco, J.L. (José Luis)|||/items/626cda34-5a0d-43e1-a34e-33d5f8c77fa6 Beloqui, O. (Óscar)|||/items/87d04a14-2d74-4221-8a57-12550777420d Diez-Martinez, J. (Javier)|||/items/4f3a0e43-12bf-403d-9dc7-31fab0d11d41 Zalba-Goñi, G. (Guillermo)|||/items/71410fa2-baa5-4efc-bce7-14b4b0e23802 |
| author_role |
author |
| author2 |
San-José-Enériz, G. (Gorka)|||/items/362ac8c3-5d50-4383-9fc1-7abbed048387 Fortuño, A. (Ana)|||/items/2324831f-71b3-4d1b-afc1-594e4e1bc0c9 Miguel-Carrasco, J.L. (José Luis)|||/items/626cda34-5a0d-43e1-a34e-33d5f8c77fa6 Beloqui, O. (Óscar)|||/items/87d04a14-2d74-4221-8a57-12550777420d Diez-Martinez, J. (Javier)|||/items/4f3a0e43-12bf-403d-9dc7-31fab0d11d41 Zalba-Goñi, G. (Guillermo)|||/items/71410fa2-baa5-4efc-bce7-14b4b0e23802 |
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author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Atherosclerosis Diabetes Intima-Media Thickness NADPH oxidase Oxidative stress A640G polymorphism |
| topic |
Atherosclerosis Diabetes Intima-Media Thickness NADPH oxidase Oxidative stress A640G polymorphism |
| description |
Oxidative stress is implicated in diabetes. The NADPH oxidases are the main source of superoxide in phagocytic and vascular cells, and p22phox is a key subunit. Genetic variants of CYBA, the human p22phox gene, associate with cardiovascular disease. We investigated the association of the A640G polymorphism with diabetes and its impact on phagocytic NADPH oxidase-dependent superoxide production and subclinical atherosclerosis. We studied 1212 subjects in which clinical parameters including carotid intima-media thickness (cIMT) were assessed. The A640G polymorphism was genotyped by TaqMan probes. In 496 subjects, the NADPH oxidase-dependent superoxide production in peripheral blood mononuclear cells was assessed by chemiluminescence. The GG genotype prevalence was significantly higher in type 2 diabetic patients than in non-diabetic subjects. Peripheral blood mononuclear cells from diabetic GG patients presented higher NADPH oxidase-dependent superoxide production than those of diabetic AA/AG patients. Within the diabetic group, GG patients presented higher cIMT levels than AA/AG patients. The A640G CYBA polymorphism may be a marker of oxidative stress risk and may be indicative of subclinical atherosclerosis in type 2 diabetes. |
| publishDate |
2011 |
| dc.date.none.fl_str_mv |
2011 2011-05-16 2011 2011-01-01 2011 2011-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
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info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/17937 |
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https://hdl.handle.net/10171/17937 |
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Inglés eng |
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Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Frontiers in Bioscience |
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Frontiers in Bioscience |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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15,301629 |