High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain

Background: We evaluated whether, in subjects receiving haemodialysis (HD), the presence of diabetic foot syndrome (DFS) was associated with increased mortality compared with subjects with diabetes mellitus (DM) without DFS and with non-diabetic subjects. Methods: Retrospective, observational study...

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Autores: Dòria, Montserrat, Betriu i Bars, M. Àngels, Belart, Montserrat, Rosado, Verónica, Hernández García, Marta, Sarró, Felipe, Real, Jordi, Castelblanco Echavarría, Esmeralda, Pacheco, Linda R., Fernández i Giráldez, Elvira, Franch-Nadal, Josep, Gratacòs, Mònica, Mauricio Puente, Dídac
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/72181
Acceso en línea:https://doi.org/10.3390/jcm10071368
http://hdl.handle.net/10459.1/72181
Access Level:acceso abierto
Palabra clave:Diabetes mellitus
Haemodialysis
Diabetic foot syndrome
Foot ulcer
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spelling High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, SpainDòria, MontserratBetriu i Bars, M. ÀngelsBelart, MontserratRosado, VerónicaHernández García, MartaSarró, FelipeReal, JordiCastelblanco Echavarría, EsmeraldaPacheco, Linda R.Fernández i Giráldez, ElviraFranch-Nadal, JosepGratacòs, MònicaMauricio Puente, DídacDiabetes mellitusHaemodialysisDiabetic foot syndromeFoot ulcerBackground: We evaluated whether, in subjects receiving haemodialysis (HD), the presence of diabetic foot syndrome (DFS) was associated with increased mortality compared with subjects with diabetes mellitus (DM) without DFS and with non-diabetic subjects. Methods: Retrospective, observational study in 220 subjects followed for six years. We calculated and compared the frequency and 5-year cumulative incidence of all-cause mortality, cardiovascular (CV) mortality, CV events, major adverse CV events (MACE), and new foot ulcer (FU) or amputation. We also examined prognostic factors of all-cause and CV mortality based on baseline characteristics. Results: DM patients had a 1.98 times higher probability of all-cause mortality than those without DM (p = 0.001) and 2.42 times higher likelihood of CV mortality and new FU or amputation (p = 0.002 and p = 0.008, respectively). In the DM cohort, only the risk of a new FU or amputation was 2.69 times higher among those with previous DFS (p = 0.021). In patients with DM, older age was the only predictor of all-cause and CV mortality (p = 0.001 and p = 0.014, respectively). Conclusions: Although all-cause and CV mortality were increased on HD subjects with DM, the presence of DFS did not modify the excess risk. Additional studies are warranted to further explore the impact of DFS in subjects with DM undergoing HD.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3390/jcm10071368http://hdl.handle.net/10459.1/72181reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a https://doi.org/10.3390/jcm10071368Journal of Clinical Medicine, 2021, vol. 10, núm. 7cc-by, (c) Dòria et al., 2021info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/721812026-06-24T12:42:17Z
dc.title.none.fl_str_mv High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
title High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
spellingShingle High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
Dòria, Montserrat
Diabetes mellitus
Haemodialysis
Diabetic foot syndrome
Foot ulcer
title_short High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
title_full High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
title_fullStr High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
title_full_unstemmed High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
title_sort High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
dc.creator.none.fl_str_mv Dòria, Montserrat
Betriu i Bars, M. Àngels
Belart, Montserrat
Rosado, Verónica
Hernández García, Marta
Sarró, Felipe
Real, Jordi
Castelblanco Echavarría, Esmeralda
Pacheco, Linda R.
Fernández i Giráldez, Elvira
Franch-Nadal, Josep
Gratacòs, Mònica
Mauricio Puente, Dídac
author Dòria, Montserrat
author_facet Dòria, Montserrat
Betriu i Bars, M. Àngels
Belart, Montserrat
Rosado, Verónica
Hernández García, Marta
Sarró, Felipe
Real, Jordi
Castelblanco Echavarría, Esmeralda
Pacheco, Linda R.
Fernández i Giráldez, Elvira
Franch-Nadal, Josep
Gratacòs, Mònica
Mauricio Puente, Dídac
author_role author
author2 Betriu i Bars, M. Àngels
Belart, Montserrat
Rosado, Verónica
Hernández García, Marta
Sarró, Felipe
Real, Jordi
Castelblanco Echavarría, Esmeralda
Pacheco, Linda R.
Fernández i Giráldez, Elvira
Franch-Nadal, Josep
Gratacòs, Mònica
Mauricio Puente, Dídac
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Diabetes mellitus
Haemodialysis
Diabetic foot syndrome
Foot ulcer
topic Diabetes mellitus
Haemodialysis
Diabetic foot syndrome
Foot ulcer
description Background: We evaluated whether, in subjects receiving haemodialysis (HD), the presence of diabetic foot syndrome (DFS) was associated with increased mortality compared with subjects with diabetes mellitus (DM) without DFS and with non-diabetic subjects. Methods: Retrospective, observational study in 220 subjects followed for six years. We calculated and compared the frequency and 5-year cumulative incidence of all-cause mortality, cardiovascular (CV) mortality, CV events, major adverse CV events (MACE), and new foot ulcer (FU) or amputation. We also examined prognostic factors of all-cause and CV mortality based on baseline characteristics. Results: DM patients had a 1.98 times higher probability of all-cause mortality than those without DM (p = 0.001) and 2.42 times higher likelihood of CV mortality and new FU or amputation (p = 0.002 and p = 0.008, respectively). In the DM cohort, only the risk of a new FU or amputation was 2.69 times higher among those with previous DFS (p = 0.021). In patients with DM, older age was the only predictor of all-cause and CV mortality (p = 0.001 and p = 0.014, respectively). Conclusions: Although all-cause and CV mortality were increased on HD subjects with DM, the presence of DFS did not modify the excess risk. Additional studies are warranted to further explore the impact of DFS in subjects with DM undergoing HD.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/jcm10071368
http://hdl.handle.net/10459.1/72181
url https://doi.org/10.3390/jcm10071368
http://hdl.handle.net/10459.1/72181
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.3390/jcm10071368
Journal of Clinical Medicine, 2021, vol. 10, núm. 7
dc.rights.none.fl_str_mv cc-by, (c) Dòria et al., 2021
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by, (c) Dòria et al., 2021
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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