Toll-like receptor agonists enhance HIV-specific T cell response mediated by plasmacytoid dendritic cells in diverse HIV-1 disease progression phenotypes

[Background] Plasmacytoid dendritic cells (pDCs) sense viral and bacterial products through Toll-like receptor (TLR)-7 and -9 and translate this sensing into Interferon-α (IFN-α) production and T-cell activation. The understanding of the mechanisms involved in pDCs stimulation may contribute to HIV-...

ver descrição completa

Detalhes bibliográficos
Autores: Jiménez-León, María Reyes, Gasca-Capote, María del Carmen, Tarancón-Díez, Laura, Domínguez-Molina, Beatriz, López-Verdugo, Macarena, Ritraj, Ryan, Gallego Jiménez, Isabel, Álvarez-Ríos, Ana Isabel, Vitallé, Joana, Bachiller, Sara, Camacho, Inés, Pérez-Gómez, Alberto, Espinosa, Nuria, Roca-Oporto, Cristina, Rafii-El-Idrissi Benhnia, Mohamed, Gutiérrez Valencia, Alicia, López-Cortés, Luis Eduardo, Ruiz-Mateos, Ezequiel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/340141
Acesso em linha:http://hdl.handle.net/10261/340141
https://api.elsevier.com/content/abstract/scopus_id/85151438415
Access Level:acceso abierto
Palavra-chave:HIV-1 restriction factors and immunotherapy
HIV-Infection
Plasmacytoid dendritic cells
TLR agonists
Descrição
Resumo:[Background] Plasmacytoid dendritic cells (pDCs) sense viral and bacterial products through Toll-like receptor (TLR)-7 and -9 and translate this sensing into Interferon-α (IFN-α) production and T-cell activation. The understanding of the mechanisms involved in pDCs stimulation may contribute to HIV-cure immunotherapeutic strategies. The objective of the present study was to characterize the immunomodulatory effects of TLR agonist stimulations in several HIV-1 disease progression phenotypes and in non HIV-1 infected donors.

Registos relacionados