The susceptibility trends of respiratory and enteric porcine pathogens to last-resource antimicrobials

Monitoring the antimicrobial susceptibility of last-resource antimicrobials for veterinary pathogens is urgently needed from a one-health perspective. The objective of this study was to analyze the antimicrobial susceptibility trends of Spanish porcine bacteria to quinolones, cephalosporins, and pol...

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Autores: Vilaró, Anna, Novell, Elena, Tarancón, Vicens, Balielles, Jordi, Migura-García, Lourdes, Fraile Sauce, Lorenzo José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/464307
Acceso en línea:https://doi.org/10.3390/antibiotics12111575
https://hdl.handle.net/10459.1/464307
Access Level:acceso abierto
Palabra clave:Trend analysis
Antimicrobial susceptibility
Porcine pathogens
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spelling The susceptibility trends of respiratory and enteric porcine pathogens to last-resource antimicrobialsVilaró, AnnaNovell, ElenaTarancón, VicensBalielles, JordiMigura-García, LourdesFraile Sauce, Lorenzo JoséTrend analysisAntimicrobial susceptibilityPorcine pathogensMonitoring the antimicrobial susceptibility of last-resource antimicrobials for veterinary pathogens is urgently needed from a one-health perspective. The objective of this study was to analyze the antimicrobial susceptibility trends of Spanish porcine bacteria to quinolones, cephalosporins, and polymyxins. Isolates of Actinobacillus pleuropneumoniae, Pasteurella multocida, and Escherichia coli were isolated from sick pigs from 2019 to 2022. An antimicrobial susceptibility test was determined based on the minimal inhibitory concentration (MIC) following an internationally accepted methodology. The MIC categorization was based on distributing the range of MIC values in four categories, with category one being the most susceptible (lowest MIC value) and category four the least susceptible (highest MIC value). Moreover, clinical susceptibility (susceptible/non-susceptible) was also determined according to the CLSI and EUCAST clinical breakpoints. A logistic and multinomial logistic regression model was used to analyze the susceptibility data for dichotomized and categorized MIC data, respectively, for any pair of antimicrobial/microorganism. In general terms, the antimicrobial susceptibility of pig bacteria to these antimicrobials remained stable or increased in the last four years in Spain. In the case of A. pleuropneumoniae and quinolones, a significant temporal trend was observed where isolates from 2020 had significantly increased odds of being more susceptible than isolates from 2019. In the case of E. coli and polymyxins, a significant temporal trend was observed where isolates from 2020 and 2021 had significantly increased odds of being more susceptible than isolates from 2019 and 2020, respectively. Finally, significant odds of being less susceptible were only observed for cephalosporins and E. coli for 2020 versus 2019, stagnating for the rest of study period. These results provide sound data on critically important antimicrobials in swine medicine.This study was carried out with the support of the Porcine Sanitation Group of Lleida, Spain, (Grup de Sanejament Porcí—GSP) in collaboration with swine practitioners working in the field.MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/antibiotics12111575https://hdl.handle.net/10459.1/464307reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a: https://doi.org/10.3390/antibiotics12111575Antibiotics-Basel, 2023, vol. 12 (11), 1575, p. 1-19cc-by (c) Vilaró et al., 2023info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/4643072026-06-24T12:42:17Z
dc.title.none.fl_str_mv The susceptibility trends of respiratory and enteric porcine pathogens to last-resource antimicrobials
title The susceptibility trends of respiratory and enteric porcine pathogens to last-resource antimicrobials
spellingShingle The susceptibility trends of respiratory and enteric porcine pathogens to last-resource antimicrobials
Vilaró, Anna
Trend analysis
Antimicrobial susceptibility
Porcine pathogens
title_short The susceptibility trends of respiratory and enteric porcine pathogens to last-resource antimicrobials
title_full The susceptibility trends of respiratory and enteric porcine pathogens to last-resource antimicrobials
title_fullStr The susceptibility trends of respiratory and enteric porcine pathogens to last-resource antimicrobials
title_full_unstemmed The susceptibility trends of respiratory and enteric porcine pathogens to last-resource antimicrobials
title_sort The susceptibility trends of respiratory and enteric porcine pathogens to last-resource antimicrobials
dc.creator.none.fl_str_mv Vilaró, Anna
Novell, Elena
Tarancón, Vicens
Balielles, Jordi
Migura-García, Lourdes
Fraile Sauce, Lorenzo José
author Vilaró, Anna
author_facet Vilaró, Anna
Novell, Elena
Tarancón, Vicens
Balielles, Jordi
Migura-García, Lourdes
Fraile Sauce, Lorenzo José
author_role author
author2 Novell, Elena
Tarancón, Vicens
Balielles, Jordi
Migura-García, Lourdes
Fraile Sauce, Lorenzo José
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Trend analysis
Antimicrobial susceptibility
Porcine pathogens
topic Trend analysis
Antimicrobial susceptibility
Porcine pathogens
description Monitoring the antimicrobial susceptibility of last-resource antimicrobials for veterinary pathogens is urgently needed from a one-health perspective. The objective of this study was to analyze the antimicrobial susceptibility trends of Spanish porcine bacteria to quinolones, cephalosporins, and polymyxins. Isolates of Actinobacillus pleuropneumoniae, Pasteurella multocida, and Escherichia coli were isolated from sick pigs from 2019 to 2022. An antimicrobial susceptibility test was determined based on the minimal inhibitory concentration (MIC) following an internationally accepted methodology. The MIC categorization was based on distributing the range of MIC values in four categories, with category one being the most susceptible (lowest MIC value) and category four the least susceptible (highest MIC value). Moreover, clinical susceptibility (susceptible/non-susceptible) was also determined according to the CLSI and EUCAST clinical breakpoints. A logistic and multinomial logistic regression model was used to analyze the susceptibility data for dichotomized and categorized MIC data, respectively, for any pair of antimicrobial/microorganism. In general terms, the antimicrobial susceptibility of pig bacteria to these antimicrobials remained stable or increased in the last four years in Spain. In the case of A. pleuropneumoniae and quinolones, a significant temporal trend was observed where isolates from 2020 had significantly increased odds of being more susceptible than isolates from 2019. In the case of E. coli and polymyxins, a significant temporal trend was observed where isolates from 2020 and 2021 had significantly increased odds of being more susceptible than isolates from 2019 and 2020, respectively. Finally, significant odds of being less susceptible were only observed for cephalosporins and E. coli for 2020 versus 2019, stagnating for the rest of study period. These results provide sound data on critically important antimicrobials in swine medicine.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/antibiotics12111575
https://hdl.handle.net/10459.1/464307
url https://doi.org/10.3390/antibiotics12111575
https://hdl.handle.net/10459.1/464307
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/antibiotics12111575
Antibiotics-Basel, 2023, vol. 12 (11), 1575, p. 1-19
dc.rights.none.fl_str_mv cc-by (c) Vilaró et al., 2023
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Vilaró et al., 2023
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
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