Effects of Caloric Restriction on Spatial Object Recognition Memory, Hippocampal Neuron Loss and Neuroinflammation in Aged Rats

Age-related neurobiological changes significantly affect hippocampal structure and function, such that the main cognitive impairments associated with aging are related to the integrity of this brain structure, including the deterioration in spatial object recognition (SOR) memory. Previous studies h...

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Autores: Portero Tresserra, Marta, Galofré López, Neus, Pallares, Elisabet, Gimenez Montes, Claudia, Barcia, Carlos, Granero, Roser, Rojic-Becker, Divka, Vale Martínez, Anna, Martí Nicolovius, Margarita, Guillazo Blanch, Gemma
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/198613
Acceso en línea:https://hdl.handle.net/2445/198613
Access Level:acceso abierto
Palabra clave:Neuroimmunologia
Envelliment
Neuroimmunology
Aging
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spelling Effects of Caloric Restriction on Spatial Object Recognition Memory, Hippocampal Neuron Loss and Neuroinflammation in Aged RatsPortero Tresserra, MartaGalofré López, NeusPallares, ElisabetGimenez Montes, ClaudiaBarcia, CarlosGranero, RoserRojic-Becker, DivkaVale Martínez, AnnaMartí Nicolovius, MargaritaGuillazo Blanch, GemmaNeuroimmunologiaEnvellimentNeuroimmunologyAgingAge-related neurobiological changes significantly affect hippocampal structure and function, such that the main cognitive impairments associated with aging are related to the integrity of this brain structure, including the deterioration in spatial object recognition (SOR) memory. Previous studies have shown that intrinsic factors such as neuroinflammation, as well as lifestyle factors such as diet, can affect aging-associated brain functions and cognitive performance. In this regard, caloric restriction (CR) produces beneficial effects on health and life expectancy, although its ability to slow down age-dependent effects on cognitive decline and hippocampus (HPC) functioning remains unclear. Therefore, we set out to evaluate the effects of CR on SOR memory in aged male Wistar rats, as well as those on hippocampal neuron loss, neurogenesis and inflammation. The data show that CR in aged rats attenuates the decline in SOR memory, age-associated hippocampal neuron loss, and age-dependent microglial activation. Furthermore, we found a significant reduction in neurogenesis in the dentate gyrus of the old animals relative to adult rats. These findings support the positive effect of CR on SOR memory, suggesting that it dampens hippocampal neuronal loss and reduces proinflammatory activity.MDPI AG2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/198613Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/nu15071572Nutrients, 2023, vol. 15, num. 7https://doi.org/10.3390/nu15071572cc by (c) Portero Tresserra, Marta et al, 2023http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1986132026-05-27T06:46:51Z
dc.title.none.fl_str_mv Effects of Caloric Restriction on Spatial Object Recognition Memory, Hippocampal Neuron Loss and Neuroinflammation in Aged Rats
title Effects of Caloric Restriction on Spatial Object Recognition Memory, Hippocampal Neuron Loss and Neuroinflammation in Aged Rats
spellingShingle Effects of Caloric Restriction on Spatial Object Recognition Memory, Hippocampal Neuron Loss and Neuroinflammation in Aged Rats
Portero Tresserra, Marta
Neuroimmunologia
Envelliment
Neuroimmunology
Aging
title_short Effects of Caloric Restriction on Spatial Object Recognition Memory, Hippocampal Neuron Loss and Neuroinflammation in Aged Rats
title_full Effects of Caloric Restriction on Spatial Object Recognition Memory, Hippocampal Neuron Loss and Neuroinflammation in Aged Rats
title_fullStr Effects of Caloric Restriction on Spatial Object Recognition Memory, Hippocampal Neuron Loss and Neuroinflammation in Aged Rats
title_full_unstemmed Effects of Caloric Restriction on Spatial Object Recognition Memory, Hippocampal Neuron Loss and Neuroinflammation in Aged Rats
title_sort Effects of Caloric Restriction on Spatial Object Recognition Memory, Hippocampal Neuron Loss and Neuroinflammation in Aged Rats
dc.creator.none.fl_str_mv Portero Tresserra, Marta
Galofré López, Neus
Pallares, Elisabet
Gimenez Montes, Claudia
Barcia, Carlos
Granero, Roser
Rojic-Becker, Divka
Vale Martínez, Anna
Martí Nicolovius, Margarita
Guillazo Blanch, Gemma
author Portero Tresserra, Marta
author_facet Portero Tresserra, Marta
Galofré López, Neus
Pallares, Elisabet
Gimenez Montes, Claudia
Barcia, Carlos
Granero, Roser
Rojic-Becker, Divka
Vale Martínez, Anna
Martí Nicolovius, Margarita
Guillazo Blanch, Gemma
author_role author
author2 Galofré López, Neus
Pallares, Elisabet
Gimenez Montes, Claudia
Barcia, Carlos
Granero, Roser
Rojic-Becker, Divka
Vale Martínez, Anna
Martí Nicolovius, Margarita
Guillazo Blanch, Gemma
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neuroimmunologia
Envelliment
Neuroimmunology
Aging
topic Neuroimmunologia
Envelliment
Neuroimmunology
Aging
description Age-related neurobiological changes significantly affect hippocampal structure and function, such that the main cognitive impairments associated with aging are related to the integrity of this brain structure, including the deterioration in spatial object recognition (SOR) memory. Previous studies have shown that intrinsic factors such as neuroinflammation, as well as lifestyle factors such as diet, can affect aging-associated brain functions and cognitive performance. In this regard, caloric restriction (CR) produces beneficial effects on health and life expectancy, although its ability to slow down age-dependent effects on cognitive decline and hippocampus (HPC) functioning remains unclear. Therefore, we set out to evaluate the effects of CR on SOR memory in aged male Wistar rats, as well as those on hippocampal neuron loss, neurogenesis and inflammation. The data show that CR in aged rats attenuates the decline in SOR memory, age-associated hippocampal neuron loss, and age-dependent microglial activation. Furthermore, we found a significant reduction in neurogenesis in the dentate gyrus of the old animals relative to adult rats. These findings support the positive effect of CR on SOR memory, suggesting that it dampens hippocampal neuronal loss and reduces proinflammatory activity.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/198613
url https://hdl.handle.net/2445/198613
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/nu15071572
Nutrients, 2023, vol. 15, num. 7
https://doi.org/10.3390/nu15071572
dc.rights.none.fl_str_mv cc by (c) Portero Tresserra, Marta et al, 2023
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Portero Tresserra, Marta et al, 2023
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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