A European-Japanese study on peach allergy: IgE to Pru p 7 associates with severity

Background: Pru p 3 and Pru p 7 have been implicated as risk factors for severe peach allergy. This study aimed to establish sensitization patterns to five peach components across Europe and in Japan, to explore their relation to pollen and foods and to predict symptom severity. Methods: In twelve E...

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Detalhes bibliográficos
Autores: Kallen, E.J.J., Revers, A., Fernández-Rivas, M., Asero, R., Ballmer-Weber, B., Barreales, L., Belohlavkova, S., de Blay, F., Clausen, M., Dubakiene, R., Ebisawa, M., Fernández Pérez, Cristina, Fritsche, P., Fukutomi, Y., Gislason, D., Hoffmann-Sommergruber, K., Jedrzejczak-Czechowicz, M., Knulst, A.C., Kowalski, M.L., Kralimarkova, T., Lidholm, J., Metzler, C., Mills, E.N.C., Papadopoulos, N.G., Popov, T.A., Purohit, A., Reig, I., Seneviratne, S.L., Sinaniotis, A., Takei, M., Versteeg, S.A., Vassilopoulou, A.E., Vieths, S., Welsing, P.M.J., Zwinderman, A.H., Le, T.M., Van Ree, R.
Tipo de documento: artigo
Data de publicação:2023
País:España
Recursos:Servizo Galego de Saúde (SERGAS)
Repositório:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/20976
Acesso em linha:https://portalcientifico.sergas.gal//documentos/64a0c05392f9861a6d05ef39
http://hdl.handle.net/20.500.11940/20976
Access Level:Acceso aberto
Palavra-chave:Humans
Prunus persica
Food Hypersensitivity
Allergens
Antigens, Plant
Immunoglobulin E
Plant Proteins
AS Santiago
CHUS
Descrição
Resumo:Background: Pru p 3 and Pru p 7 have been implicated as risk factors for severe peach allergy. This study aimed to establish sensitization patterns to five peach components across Europe and in Japan, to explore their relation to pollen and foods and to predict symptom severity. Methods: In twelve European (EuroPrevall project) and one Japanese outpatient clinic, a standardized clinical evaluation was conducted in 1231 patients who reported symptoms to peach and/or were sensitized to peach. Specific IgE against Pru p 1, 2, 3, 4 and 7 and against Cup s 7 was measured in 474 of them. Univariable and multivariable Lasso regression was applied to identify combinations of parameters predicting severity. Results: Sensitization to Pru p 3 dominated in Southern Europe but was also quite common in Northern and Central Europe. Sensitization to Pru p 7 was low and variable in the European centers but very dominant in Japan. Severity could be predicted by a model combining age of onset of peach allergy, probable mugwort, Parietaria pollen and latex allergy, and sensitization to Japanese cedar pollen, Pru p 4 and Pru p 7 which resulted in an AUC of 0.73 (95% CI 0.73-0.74). Pru p 3 tended to be a risk factor in South Europe only. Conclusions: Pru p 7 was confirmed as a significant risk factor for severe peach allergy in Europe and Japan. Combining outcomes from clinical and demographic background with serology resulted in a model that could better predict severity than CRD alone.

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