Relationship between the choice of clinical treatment, gait functionality and kinetics in patients with comparable knee osteoarthritis

Objective: The objective of this study was to investigate the relationship between the choice of clinical treatment, gait functionality, and kinetics in patients with comparable knee osteoarthritis. Design: This was an observational case-control study. Setting: The study was conducted in a universit...

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Autores: Tassani, Simone, Tío, Laura, Castro Domínguez, Francisco, Monfort, Jordi, Monllau García, Juan Carlos, González Ballester, Miguel Ángel, 1973-, Noailly, Jérôme
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/54100
Acceso en línea:http://hdl.handle.net/10230/54100
http://dx.doi.org/10.3389/fbioe.2022.820186
Access Level:acceso abierto
Palabra clave:Knee osteoarthritis (KOA)
Confounding adjustment
Functionality
Gait
Multifactorial analysis
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spelling Relationship between the choice of clinical treatment, gait functionality and kinetics in patients with comparable knee osteoarthritisTassani, SimoneTío, LauraCastro Domínguez, FranciscoMonfort, JordiMonllau García, Juan CarlosGonzález Ballester, Miguel Ángel, 1973-Noailly, JérômeKnee osteoarthritis (KOA)Confounding adjustmentFunctionalityGaitMultifactorial analysisObjective: The objective of this study was to investigate the relationship between the choice of clinical treatment, gait functionality, and kinetics in patients with comparable knee osteoarthritis. Design: This was an observational case-control study. Setting: The study was conducted in a university biomechanics laboratory. Participants: Knee osteoarthritis patients were stratified into the following groups: clinical treatment (conservative/total knee replacement (TKR) planned), sex (male/female), age (60-67/68-75), and body mass index (BMI) (<30/≥30). All patients had a Kellgren-Lawrence score of 2 or 3 (N = 87). Main Outcome Measures: All patients underwent gait analysis, and two groups of dependent variables were extracted: • Spatiotemporal gait variables: gait velocity, stride time, and double-support time, which are associated with patient functionality. • Kinetic gait variables: vertical, anterior-posterior, and mediolateral ground reaction forces, vertical free moment, joint forces, and moments at the ankle, knee, and hip. Multifactorial and multivariate analyses of variance were performed. Results: Functionality relates to treatment decisions, with patients in the conservative group walking 25% faster and spending 24% less time in the double-support phase. However, these differences vary with age and are reduced in older subjects. Patients who planned to undergo TKR did not present higher knee forces, and different joint moments between clinical treatments depended on the age and BMI of the subjects. Conclusions: Knee osteoarthritis is a multifactorial disease, with age and BMI being confounding factors. The differences in gait between the two groups were mitigated by confounding factors and risk factors, such as being a woman, elderly, and obese, reducing the variability of the gait compression loads. These factors should always be considered in gait studies of patients with knee osteoarthritis to control for confounding effects.Funds from the Spanish Government (HOLOA-DPI2016-80283-C2-1/2-R, RYC-2015-18888, MDM-2015-0502) and from DTIC-UPF are acknowledged.Frontiers202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/54100http://dx.doi.org/10.3389/fbioe.2022.820186reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésFront Bioeng Biotechnol. 2022 Mar 11;10:820186info:eu-repo/grantAgreement/ES/1PE/DPI2016-80283-C2-1-Rinfo:eu-repo/grantAgreement/ES/1PE/DPI2016-80283-C2-2-R© 2022 Tassani, Tio, Castro-Domínguez, Monfort, Monllau, González Ballester and Noailly. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/541002026-06-12T07:21:37Z
dc.title.none.fl_str_mv Relationship between the choice of clinical treatment, gait functionality and kinetics in patients with comparable knee osteoarthritis
title Relationship between the choice of clinical treatment, gait functionality and kinetics in patients with comparable knee osteoarthritis
spellingShingle Relationship between the choice of clinical treatment, gait functionality and kinetics in patients with comparable knee osteoarthritis
Tassani, Simone
Knee osteoarthritis (KOA)
Confounding adjustment
Functionality
Gait
Multifactorial analysis
title_short Relationship between the choice of clinical treatment, gait functionality and kinetics in patients with comparable knee osteoarthritis
title_full Relationship between the choice of clinical treatment, gait functionality and kinetics in patients with comparable knee osteoarthritis
title_fullStr Relationship between the choice of clinical treatment, gait functionality and kinetics in patients with comparable knee osteoarthritis
title_full_unstemmed Relationship between the choice of clinical treatment, gait functionality and kinetics in patients with comparable knee osteoarthritis
title_sort Relationship between the choice of clinical treatment, gait functionality and kinetics in patients with comparable knee osteoarthritis
dc.creator.none.fl_str_mv Tassani, Simone
Tío, Laura
Castro Domínguez, Francisco
Monfort, Jordi
Monllau García, Juan Carlos
González Ballester, Miguel Ángel, 1973-
Noailly, Jérôme
author Tassani, Simone
author_facet Tassani, Simone
Tío, Laura
Castro Domínguez, Francisco
Monfort, Jordi
Monllau García, Juan Carlos
González Ballester, Miguel Ángel, 1973-
Noailly, Jérôme
author_role author
author2 Tío, Laura
Castro Domínguez, Francisco
Monfort, Jordi
Monllau García, Juan Carlos
González Ballester, Miguel Ángel, 1973-
Noailly, Jérôme
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Knee osteoarthritis (KOA)
Confounding adjustment
Functionality
Gait
Multifactorial analysis
topic Knee osteoarthritis (KOA)
Confounding adjustment
Functionality
Gait
Multifactorial analysis
description Objective: The objective of this study was to investigate the relationship between the choice of clinical treatment, gait functionality, and kinetics in patients with comparable knee osteoarthritis. Design: This was an observational case-control study. Setting: The study was conducted in a university biomechanics laboratory. Participants: Knee osteoarthritis patients were stratified into the following groups: clinical treatment (conservative/total knee replacement (TKR) planned), sex (male/female), age (60-67/68-75), and body mass index (BMI) (<30/≥30). All patients had a Kellgren-Lawrence score of 2 or 3 (N = 87). Main Outcome Measures: All patients underwent gait analysis, and two groups of dependent variables were extracted: • Spatiotemporal gait variables: gait velocity, stride time, and double-support time, which are associated with patient functionality. • Kinetic gait variables: vertical, anterior-posterior, and mediolateral ground reaction forces, vertical free moment, joint forces, and moments at the ankle, knee, and hip. Multifactorial and multivariate analyses of variance were performed. Results: Functionality relates to treatment decisions, with patients in the conservative group walking 25% faster and spending 24% less time in the double-support phase. However, these differences vary with age and are reduced in older subjects. Patients who planned to undergo TKR did not present higher knee forces, and different joint moments between clinical treatments depended on the age and BMI of the subjects. Conclusions: Knee osteoarthritis is a multifactorial disease, with age and BMI being confounding factors. The differences in gait between the two groups were mitigated by confounding factors and risk factors, such as being a woman, elderly, and obese, reducing the variability of the gait compression loads. These factors should always be considered in gait studies of patients with knee osteoarthritis to control for confounding effects.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/54100
http://dx.doi.org/10.3389/fbioe.2022.820186
url http://hdl.handle.net/10230/54100
http://dx.doi.org/10.3389/fbioe.2022.820186
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Front Bioeng Biotechnol. 2022 Mar 11;10:820186
info:eu-repo/grantAgreement/ES/1PE/DPI2016-80283-C2-1-R
info:eu-repo/grantAgreement/ES/1PE/DPI2016-80283-C2-2-R
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
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application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
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