Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment

[EN] The tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all stages of tumor progression. The contribution of stromal cells to the reprogramming of the TME is not well understood. Here, we provide evidence of the role of the cytokine oncostatin M (OSM) as central nod...

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Detalles Bibliográficos
Autores: Araujo, Angela M., Abaurrea Larrañaga, Andrea, Azcoaga Azcoaga, Peio, López Velazco, Joanna Inés, Manzano, Sara, Rodríguez Martínez, Javier, Rezola, Ricardo, Egia Mendikute, Leire, Valdés Mora, Fátima, Flores, Juana M., Jenkins, Liam, Pulido, Laura, Osorio Querejeta, Iñaki, Fernández Nogueira, Patricia, Ferrari, Nicola, Viera, Cristina, Martín Martín, Natalia, Tzankov, Alexandar, Eppenberger Castori, Serenella, Álvarez López, Isabel, Urruticoechea, Ander, Bragado, Paloma, Coleman, Nicholas, Palazón García, Francisco de Asís, Carracedo Pérez, Arkaitz, Gallego Ortega, David, Calvo González, Fernando, Isacke, Clare M., Muñoz Caffarel, Maria, Lawrie, Charles
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/56368
Acceso en línea:http://hdl.handle.net/10810/56368
Access Level:acceso abierto
Palabra clave:breast cancer
chemokines
cytokines
inflammation
oncology
Descripción
Sumario:[EN] The tumor microenvironment (TME) is reprogrammed by cancer cells and participates in all stages of tumor progression. The contribution of stromal cells to the reprogramming of the TME is not well understood. Here, we provide evidence of the role of the cytokine oncostatin M (OSM) as central node for multicellular interactions between immune and nonimmune stromal cells and the epithelial cancer cell compartment. OSM receptor (OSMR) deletion in a multistage breast cancer model halted tumor progression. We ascribed causality to the stromal function of the OSM axis by demonstrating reduced tumor burden of syngeneic tumors implanted in mice lacking OSMR. Single-cell and bioinformatic analysis of murine and human breast tumors revealed that OSM expression was restricted to myeloid cells, whereas OSMR was detected predominantly in fibroblasts and, to a lower extent, cancer cells. Myeloid-derived OSM reprogrammed fibroblasts to a more contractile and tumorigenic phenotype and elicited the secretion of VEGF and proinflammatory chemokines CXCL1 and CXCL16, leading to increased myeloid cell recruitment. Collectively, our data support the notion that the stromal OSM/OSMR axis reprograms the immune and nonimmune microenvironment and plays a key role in breast cancer progression.

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