Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring.

Ramírez-López, María Teresa; Arco, Raquel; Decara, Juan; Vázquez, Mariam; Noemí Blanco, Rosario; Alén, Francisco; Suárez, Juan; Gómez de Heras, Raquel; Rodríguez de Fonseca, Fernando

Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring.

Recent studies have linked gestational exposure to highly caloric diets with a disrupted endogenous cannabinoid system (ECS). In the present study, we have extended these studies by analyzing the impact of the exposure to a palatable diet during gestation and lactation on a) the adult expression of...

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Autores:	Ramírez-López, María Teresa, Arco, Raquel, Decara, Juan, Vázquez, Mariam, Noemí Blanco, Rosario, Alén, Francisco, Suárez, Juan, Gómez de Heras, Raquel, Rodríguez de Fonseca, Fernando
Formato:	artículo
Fecha de publicación:	2016
País:	España
Recursos:	Instituto de Salud Carlos III (ISCIII)
Repositorio:	Repisalud
Idioma:	inglés
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/17168
Acesso em linha:	http://hdl.handle.net/20.500.12105/17168
Access Level:	acceso abierto
Palavra-chave:	Adipose Tissue Animals Animals, Newborn Brain Diet, High-Fat Endocannabinoids Female Gene Expression Regulation, Developmental Liver Piperidines Pregnancy Pyrazoles Rats Receptor, Cannabinoid, CB1 Receptor, Cannabinoid, CB2 Sex Characteristics Signal Transduction

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spelling	Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring.Ramírez-López, María TeresaArco, RaquelDecara, JuanVázquez, MariamNoemí Blanco, RosarioAlén, FranciscoSuárez, JuanGómez de Heras, RaquelRodríguez de Fonseca, FernandoAdipose TissueAnimalsAnimals, NewbornBrainDiet, High-FatEndocannabinoidsFemaleGene Expression Regulation, DevelopmentalLiverPiperidinesPregnancyPyrazolesRatsReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Sex CharacteristicsSignal TransductionRecent studies have linked gestational exposure to highly caloric diets with a disrupted endogenous cannabinoid system (ECS). In the present study, we have extended these studies by analyzing the impact of the exposure to a palatable diet during gestation and lactation on a) the adult expression of endocannabinoid-related behaviors, b) the metabolic profile of adult offspring and c) the mRNA expression of the signaling machinery of the ECS in the hypothalamus, the liver and the adipose tissue of adult offspring of both sexes. Exposure to a palatable diet resulted in a) sex-dimorphic and perinatal diet specific feeding behaviors, including the differential response to the inhibitory effects of the cannabinoid receptor inverse agonist AM251, b) features of metabolic syndrome including increased adiposity, hyperleptinemia, hypertriglyceridemia and hypercholesterolemia and c) tissue and sex-specific changes in the expression of both CB1 and CB2 receptors and in that of the endocannabinoid-degrading enzymes FAAH and MAGL, being the adipose tissue the most affected organ analyzed. Since the effects were observed in adult animals that were weaned while consuming a normal diet, the present results indicate that the ECS is one of the targets of maternal programming of the offspring energy expenditure. These results clearly indicate that the maternal diet has long-term effects on the development of pups through multiple alterations of signaling homeostatic pathways that include the ECS. The potential relevance of these alterations for the current obesity epidemic is discussed.20242024-01-1620162016-11-0220162016-11-02research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/17168reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/171682026-06-12T12:43:37Z
dc.title.none.fl_str_mv	Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring.
title	Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring.
spellingShingle	Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring. Ramírez-López, María Teresa Adipose Tissue Animals Animals, Newborn Brain Diet, High-Fat Endocannabinoids Female Gene Expression Regulation, Developmental Liver Piperidines Pregnancy Pyrazoles Rats Receptor, Cannabinoid, CB1 Receptor, Cannabinoid, CB2 Sex Characteristics Signal Transduction
title_short	Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring.
title_full	Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring.
title_fullStr	Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring.
title_full_unstemmed	Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring.
title_sort	Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring.
dc.creator.none.fl_str_mv	Ramírez-López, María Teresa Arco, Raquel Decara, Juan Vázquez, Mariam Noemí Blanco, Rosario Alén, Francisco Suárez, Juan Gómez de Heras, Raquel Rodríguez de Fonseca, Fernando
author	Ramírez-López, María Teresa
author_facet	Ramírez-López, María Teresa Arco, Raquel Decara, Juan Vázquez, Mariam Noemí Blanco, Rosario Alén, Francisco Suárez, Juan Gómez de Heras, Raquel Rodríguez de Fonseca, Fernando
author_role	author
author2	Arco, Raquel Decara, Juan Vázquez, Mariam Noemí Blanco, Rosario Alén, Francisco Suárez, Juan Gómez de Heras, Raquel Rodríguez de Fonseca, Fernando
author2_role	author author author author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	Adipose Tissue Animals Animals, Newborn Brain Diet, High-Fat Endocannabinoids Female Gene Expression Regulation, Developmental Liver Piperidines Pregnancy Pyrazoles Rats Receptor, Cannabinoid, CB1 Receptor, Cannabinoid, CB2 Sex Characteristics Signal Transduction
topic	Adipose Tissue Animals Animals, Newborn Brain Diet, High-Fat Endocannabinoids Female Gene Expression Regulation, Developmental Liver Piperidines Pregnancy Pyrazoles Rats Receptor, Cannabinoid, CB1 Receptor, Cannabinoid, CB2 Sex Characteristics Signal Transduction
description	Recent studies have linked gestational exposure to highly caloric diets with a disrupted endogenous cannabinoid system (ECS). In the present study, we have extended these studies by analyzing the impact of the exposure to a palatable diet during gestation and lactation on a) the adult expression of endocannabinoid-related behaviors, b) the metabolic profile of adult offspring and c) the mRNA expression of the signaling machinery of the ECS in the hypothalamus, the liver and the adipose tissue of adult offspring of both sexes. Exposure to a palatable diet resulted in a) sex-dimorphic and perinatal diet specific feeding behaviors, including the differential response to the inhibitory effects of the cannabinoid receptor inverse agonist AM251, b) features of metabolic syndrome including increased adiposity, hyperleptinemia, hypertriglyceridemia and hypercholesterolemia and c) tissue and sex-specific changes in the expression of both CB1 and CB2 receptors and in that of the endocannabinoid-degrading enzymes FAAH and MAGL, being the adipose tissue the most affected organ analyzed. Since the effects were observed in adult animals that were weaned while consuming a normal diet, the present results indicate that the ECS is one of the targets of maternal programming of the offspring energy expenditure. These results clearly indicate that the maternal diet has long-term effects on the development of pups through multiple alterations of signaling homeostatic pathways that include the ECS. The potential relevance of these alterations for the current obesity epidemic is discussed.
publishDate	2016
dc.date.none.fl_str_mv	2016 2016-11-02 2016 2016-11-02 2024 2024-01-16
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.12105/17168
url	http://hdl.handle.net/20.500.12105/17168
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
reponame_str	Repisalud
collection	Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869414691520905216
score	15,812429

Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring.

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