A Universal Antigen-Ranking Method to Design Personalized Vaccines Targeting Neoantigens against Melanoma

Background: The main purpose of this article is to introduce a universal mathematics-aided vaccine design method against malignant melanoma based on neoantigens. The universal method can be adapted to the mutanome of each patient so that a specific candidate vaccine can be tailored for the correspon...

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Detalles Bibliográficos
Autores: Malaina, Iker, Martínez, Luis, Montoya, Juan Manuel, Alonso, Santos, Boyano, María Dolores, Asumendi, Aintzane, Izu, Rosa, Sanchez-Diez, Ana, Cancho-Galan, Goikoane, De la Fuente, Ildefonso M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/360810
Acceso en línea:http://hdl.handle.net/10261/360810
https://api.elsevier.com/content/abstract/scopus_id/85146742215
Access Level:acceso abierto
Palabra clave:Vaccine design
Melanoma
Combinatorial optimization
Immunogenicity
Bioinformatics
Personalized medicine
Descripción
Sumario:Background: The main purpose of this article is to introduce a universal mathematics-aided vaccine design method against malignant melanoma based on neoantigens. The universal method can be adapted to the mutanome of each patient so that a specific candidate vaccine can be tailored for the corresponding patient

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