Biomaterials based on carbon nanotube nanocomposites of poly(styrene-b-isobutylene-b-styrene): the effect of nanotube content on the mechanical properties, biocompatibility and hemocompatibility

Nanocomposites based on poly(styrene-block-isobutylene-block-styrene) (SIBS) and single-walled carbon nanotubes (CNTs) were prepared and characterized in terms of tensile strength as well as bio- and hemocompatibility. It was shown that modification of CNTs using dodecylamine (DDA), featured by a lo...

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Authors: Rezvova, Maria A., Nikishau, Pavel A., Makarevich, Miraslau I., Glushkova, Tatiana V., Klyshnikov, Kirill Yu, Akentieva, Tatiana N., Efimova, Olga S., Nikitin, Andrey P., Malysheva, Valentina Yu, Matveeva, Vera G., Senokosova, Evgeniia A., Khanova, Mariam Yu, Danilov, Viacheslav V., Russakov, Dmitry M., Ismagilov, Zinfer R., Kostjuk, Sergei V., Ovcharenko, Evgeny A.
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Universitat Pompeu Fabra
Repository:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/71744
Online Access:http://hdl.handle.net/10230/71744
http://dx.doi.org/10.3390/nano12050733
Access Level:Open access
Keyword:Single-walled carbon nanotubes
Polymer nanocomposites
Biocompatible polymers
Interphase interaction
SIBS
Cardiovascular medical devices
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spelling Biomaterials based on carbon nanotube nanocomposites of poly(styrene-b-isobutylene-b-styrene): the effect of nanotube content on the mechanical properties, biocompatibility and hemocompatibilityRezvova, Maria A.Nikishau, Pavel A.Makarevich, Miraslau I.Glushkova, Tatiana V.Klyshnikov, Kirill YuAkentieva, Tatiana N.Efimova, Olga S.Nikitin, Andrey P.Malysheva, Valentina YuMatveeva, Vera G.Senokosova, Evgeniia A.Khanova, Mariam YuDanilov, Viacheslav V.Russakov, Dmitry M.Ismagilov, Zinfer R.Kostjuk, Sergei V.Ovcharenko, Evgeny A.Single-walled carbon nanotubesPolymer nanocompositesBiocompatible polymersInterphase interactionSIBSCardiovascular medical devicesNanocomposites based on poly(styrene-block-isobutylene-block-styrene) (SIBS) and single-walled carbon nanotubes (CNTs) were prepared and characterized in terms of tensile strength as well as bio- and hemocompatibility. It was shown that modification of CNTs using dodecylamine (DDA), featured by a long non-polar alkane chain, provided much better dispersion of nanotubes in SIBS as compared to unmodified CNTs. As a result of such modification, the tensile strength of the nanocomposite based on SIBS with low molecular weight (Mn = 40,000 g mol–1) containing 4% of functionalized CNTs was increased up to 5.51 ± 0.50 MPa in comparison with composites with unmodified CNTs (3.81 ± 0.11 MPa). However, the addition of CNTs had no significant effect on SIBS with high molecular weight (Mn~70,000 g mol−1) with ultimate tensile stress of pure polymer of 11.62 MPa and 14.45 MPa in case of its modification with 1 wt% of CNT-DDA. Enhanced biocompatibility of nanocomposites as compared to neat SIBS has been demonstrated in experiment with EA.hy 926 cells. However, the platelet aggregation observed at high CNT concentrations can cause thrombosis. Therefore, SIBS with higher molecular weight (Mn~70,000 g mol−1) reinforced by 1–2 wt% of CNTs is the most promising material for the development of cardiovascular implants such as heart valve prostheses.MDPI202520252022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/71744http://dx.doi.org/10.3390/nano12050733reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNanomaterials. 2022 Feb 22;12(5):733© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/717442026-06-12T07:21:37Z
dc.title.none.fl_str_mv Biomaterials based on carbon nanotube nanocomposites of poly(styrene-b-isobutylene-b-styrene): the effect of nanotube content on the mechanical properties, biocompatibility and hemocompatibility
title Biomaterials based on carbon nanotube nanocomposites of poly(styrene-b-isobutylene-b-styrene): the effect of nanotube content on the mechanical properties, biocompatibility and hemocompatibility
spellingShingle Biomaterials based on carbon nanotube nanocomposites of poly(styrene-b-isobutylene-b-styrene): the effect of nanotube content on the mechanical properties, biocompatibility and hemocompatibility
Rezvova, Maria A.
Single-walled carbon nanotubes
Polymer nanocomposites
Biocompatible polymers
Interphase interaction
SIBS
Cardiovascular medical devices
title_short Biomaterials based on carbon nanotube nanocomposites of poly(styrene-b-isobutylene-b-styrene): the effect of nanotube content on the mechanical properties, biocompatibility and hemocompatibility
title_full Biomaterials based on carbon nanotube nanocomposites of poly(styrene-b-isobutylene-b-styrene): the effect of nanotube content on the mechanical properties, biocompatibility and hemocompatibility
title_fullStr Biomaterials based on carbon nanotube nanocomposites of poly(styrene-b-isobutylene-b-styrene): the effect of nanotube content on the mechanical properties, biocompatibility and hemocompatibility
title_full_unstemmed Biomaterials based on carbon nanotube nanocomposites of poly(styrene-b-isobutylene-b-styrene): the effect of nanotube content on the mechanical properties, biocompatibility and hemocompatibility
title_sort Biomaterials based on carbon nanotube nanocomposites of poly(styrene-b-isobutylene-b-styrene): the effect of nanotube content on the mechanical properties, biocompatibility and hemocompatibility
dc.creator.none.fl_str_mv Rezvova, Maria A.
Nikishau, Pavel A.
Makarevich, Miraslau I.
Glushkova, Tatiana V.
Klyshnikov, Kirill Yu
Akentieva, Tatiana N.
Efimova, Olga S.
Nikitin, Andrey P.
Malysheva, Valentina Yu
Matveeva, Vera G.
Senokosova, Evgeniia A.
Khanova, Mariam Yu
Danilov, Viacheslav V.
Russakov, Dmitry M.
Ismagilov, Zinfer R.
Kostjuk, Sergei V.
Ovcharenko, Evgeny A.
author Rezvova, Maria A.
author_facet Rezvova, Maria A.
Nikishau, Pavel A.
Makarevich, Miraslau I.
Glushkova, Tatiana V.
Klyshnikov, Kirill Yu
Akentieva, Tatiana N.
Efimova, Olga S.
Nikitin, Andrey P.
Malysheva, Valentina Yu
Matveeva, Vera G.
Senokosova, Evgeniia A.
Khanova, Mariam Yu
Danilov, Viacheslav V.
Russakov, Dmitry M.
Ismagilov, Zinfer R.
Kostjuk, Sergei V.
Ovcharenko, Evgeny A.
author_role author
author2 Nikishau, Pavel A.
Makarevich, Miraslau I.
Glushkova, Tatiana V.
Klyshnikov, Kirill Yu
Akentieva, Tatiana N.
Efimova, Olga S.
Nikitin, Andrey P.
Malysheva, Valentina Yu
Matveeva, Vera G.
Senokosova, Evgeniia A.
Khanova, Mariam Yu
Danilov, Viacheslav V.
Russakov, Dmitry M.
Ismagilov, Zinfer R.
Kostjuk, Sergei V.
Ovcharenko, Evgeny A.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Single-walled carbon nanotubes
Polymer nanocomposites
Biocompatible polymers
Interphase interaction
SIBS
Cardiovascular medical devices
topic Single-walled carbon nanotubes
Polymer nanocomposites
Biocompatible polymers
Interphase interaction
SIBS
Cardiovascular medical devices
description Nanocomposites based on poly(styrene-block-isobutylene-block-styrene) (SIBS) and single-walled carbon nanotubes (CNTs) were prepared and characterized in terms of tensile strength as well as bio- and hemocompatibility. It was shown that modification of CNTs using dodecylamine (DDA), featured by a long non-polar alkane chain, provided much better dispersion of nanotubes in SIBS as compared to unmodified CNTs. As a result of such modification, the tensile strength of the nanocomposite based on SIBS with low molecular weight (Mn = 40,000 g mol–1) containing 4% of functionalized CNTs was increased up to 5.51 ± 0.50 MPa in comparison with composites with unmodified CNTs (3.81 ± 0.11 MPa). However, the addition of CNTs had no significant effect on SIBS with high molecular weight (Mn~70,000 g mol−1) with ultimate tensile stress of pure polymer of 11.62 MPa and 14.45 MPa in case of its modification with 1 wt% of CNT-DDA. Enhanced biocompatibility of nanocomposites as compared to neat SIBS has been demonstrated in experiment with EA.hy 926 cells. However, the platelet aggregation observed at high CNT concentrations can cause thrombosis. Therefore, SIBS with higher molecular weight (Mn~70,000 g mol−1) reinforced by 1–2 wt% of CNTs is the most promising material for the development of cardiovascular implants such as heart valve prostheses.
publishDate 2022
dc.date.none.fl_str_mv 2022
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/71744
http://dx.doi.org/10.3390/nano12050733
url http://hdl.handle.net/10230/71744
http://dx.doi.org/10.3390/nano12050733
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nanomaterials. 2022 Feb 22;12(5):733
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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