Trifluoromethyl Thianthrenium Salts
Trifluoromethyl thianthrenium salts have recently emerged as powerful and versatile reagents in organic chemistry, enabling the direct transfer of the CF3 group under mild and operationally simple conditions. Its straightforward, scalable synthesis from inexpensive starting materials provides a prac...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:325879 |
| Acceso en línea: | https://ddd.uab.cat/record/325879 https://dx.doi.org/urn:doi:10.1021/acs.joc.5c02822 |
| Access Level: | acceso abierto |
| Palabra clave: | Hydrocarbons Reagents Trifluoromethyl Trifluoromethylation |
| Sumario: | Trifluoromethyl thianthrenium salts have recently emerged as powerful and versatile reagents in organic chemistry, enabling the direct transfer of the CF3 group under mild and operationally simple conditions. Its straightforward, scalable synthesis from inexpensive starting materials provides a practical alternative to classical Umemoto- and Togni-type reagents. Beyond its role as a trifluoromethylating agent, trifluoromethyl thianthrenium salts have unlocked new classes of reagents and innovative activation modes, ranging radical, photochemical, electrochemical, mechanochemical, and even magnetoredox processes. This unique versatility has expanded the synthetic toolbox for constructing fluorine-containing molecules of interest to pharmaceuticals, agrochemicals, and functional materials. Furthermore, recent breakthroughs demonstrate that trifluoromethyl thianthrenium salts extend beyond molecular synthesis into materials settings, enabling controlled functionalization and defect passivation of two-dimensional (2D) semiconductors, thereby bridging fundamental chemical reactivity with device-level applications. This Perspective highlights the synthesis, reactivity, and emerging applications of trifluoromethyl thianthrenium salts, emphasizing how these reagents exemplify the growing interface between fluorine chemistry, radical reactivity, and materials science. |
|---|