Unraveling the impact of prenatal air pollution for neonatal brain maturation
Early brain development is highly sensitive to environmental influences. While prenatal exposure to airborne particulate matter (PM2.5) has been broadly associated with harmful effects, PM2.5 also contains trace elements such as iron, copper and zinc, which are essential for brain growth. This study...
| Autores: | , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/401763 |
| Acceso en línea: | http://hdl.handle.net/10261/401763 https://api.elsevier.com/content/abstract/scopus_id/105016638318 |
| Access Level: | acceso abierto |
| Palabra clave: | Particulate matter Brain development Myelination Neonates http://metadata.un.org/sdg/11 http://metadata.un.org/sdg/9 http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation Make cities and human settlements inclusive, safe, resilient and sustainable |
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Unraveling the impact of prenatal air pollution for neonatal brain maturation |
| title |
Unraveling the impact of prenatal air pollution for neonatal brain maturation |
| spellingShingle |
Unraveling the impact of prenatal air pollution for neonatal brain maturation Pujol, Jesus Particulate matter Brain development Myelination Neonates http://metadata.un.org/sdg/11 http://metadata.un.org/sdg/9 http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation Make cities and human settlements inclusive, safe, resilient and sustainable |
| title_short |
Unraveling the impact of prenatal air pollution for neonatal brain maturation |
| title_full |
Unraveling the impact of prenatal air pollution for neonatal brain maturation |
| title_fullStr |
Unraveling the impact of prenatal air pollution for neonatal brain maturation |
| title_full_unstemmed |
Unraveling the impact of prenatal air pollution for neonatal brain maturation |
| title_sort |
Unraveling the impact of prenatal air pollution for neonatal brain maturation |
| dc.creator.none.fl_str_mv |
Pujol, Jesus Martínez-Vilavella, Gerard Gómez-Herrera, Laura Rivas, Ioar Gómez-Roig, Maria Dolors Llurba, Elisa Blanco-Hinojo, Laura Cirach, Marta Persavento, Cecilia Querol, Xavier Gascón, Mireia Foraster, Maria Gispert, Juan Domingo Falcón, Carles Deus, Joan Dadvand, Payam Sunyer, Jordi |
| author |
Pujol, Jesus |
| author_facet |
Pujol, Jesus Martínez-Vilavella, Gerard Gómez-Herrera, Laura Rivas, Ioar Gómez-Roig, Maria Dolors Llurba, Elisa Blanco-Hinojo, Laura Cirach, Marta Persavento, Cecilia Querol, Xavier Gascón, Mireia Foraster, Maria Gispert, Juan Domingo Falcón, Carles Deus, Joan Dadvand, Payam Sunyer, Jordi |
| author_role |
author |
| author2 |
Martínez-Vilavella, Gerard Gómez-Herrera, Laura Rivas, Ioar Gómez-Roig, Maria Dolors Llurba, Elisa Blanco-Hinojo, Laura Cirach, Marta Persavento, Cecilia Querol, Xavier Gascón, Mireia Foraster, Maria Gispert, Juan Domingo Falcón, Carles Deus, Joan Dadvand, Payam Sunyer, Jordi |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
European Commission 0000-0001-8948-4918 0000-0002-5929-8409 0000-0002-4743-619X 0000-0003-2329-1851 0000-0003-4537-8472 0000-0003-4450-4123 0000-0002-2602-4110 Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Particulate matter Brain development Myelination Neonates http://metadata.un.org/sdg/11 http://metadata.un.org/sdg/9 http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation Make cities and human settlements inclusive, safe, resilient and sustainable |
| topic |
Particulate matter Brain development Myelination Neonates http://metadata.un.org/sdg/11 http://metadata.un.org/sdg/9 http://metadata.un.org/sdg/3 Ensure healthy lives and promote well-being for all at all ages Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation Make cities and human settlements inclusive, safe, resilient and sustainable |
| description |
Early brain development is highly sensitive to environmental influences. While prenatal exposure to airborne particulate matter (PM2.5) has been broadly associated with harmful effects, PM2.5 also contains trace elements such as iron, copper and zinc, which are essential for brain growth. This study examined both the overall impact of prenatal PM2.5 exposure and the specific role of these trace elements on neonatal myelinated white matter-a key marker of brain maturation. This population-based study included 93 neonates recruited from three major hospitals in Barcelona (2018-2021). PM2.5 exposure was estimated for the embryonic and late fetal periods using land-use regression models incorporating time-weighted maternal mobility data. MRI was performed at 29 days postnatally. Global myelinated white matter was manually segmented, and automated cortical myelination measures were obtained in 85 cases. Associations were examined using linear regression models with and without adjustment for potential confounders. Higher prenatal PM2.5 exposure was associated with lower myelinated white matter content. Trace elements showed a similar pattern, but their associations became nonsignificant after adjusting for overall PM2.5 exposure. The findings suggest that prenatal air pollution exposure may delay early myelination. Moreover, no specific associations were identified for iron, copper, or zinc. However, given the dynamic nature of white matter maturation, such delays may not necessarily be detrimental. This study underscores the impact of environmental factors on neonatal brain development and the importance of stringent air quality policies, while emphasizing the need for longitudinal research to assess long-term cognitive and behavioral outcomes. |
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2025 |
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2025 2025 2025 |
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info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
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http://hdl.handle.net/10261/401763 https://api.elsevier.com/content/abstract/scopus_id/105016638318 |
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http://hdl.handle.net/10261/401763 https://api.elsevier.com/content/abstract/scopus_id/105016638318 |
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Unraveling the impact of prenatal air pollution for neonatal brain maturationPujol, JesusMartínez-Vilavella, GerardGómez-Herrera, LauraRivas, IoarGómez-Roig, Maria DolorsLlurba, ElisaBlanco-Hinojo, LauraCirach, MartaPersavento, CeciliaQuerol, XavierGascón, MireiaForaster, MariaGispert, Juan DomingoFalcón, CarlesDeus, JoanDadvand, PayamSunyer, JordiParticulate matterBrain developmentMyelinationNeonateshttp://metadata.un.org/sdg/11http://metadata.un.org/sdg/9http://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesBuild resilient infrastructure, promote inclusive and sustainable industrialization and foster innovationMake cities and human settlements inclusive, safe, resilient and sustainableEarly brain development is highly sensitive to environmental influences. While prenatal exposure to airborne particulate matter (PM2.5) has been broadly associated with harmful effects, PM2.5 also contains trace elements such as iron, copper and zinc, which are essential for brain growth. This study examined both the overall impact of prenatal PM2.5 exposure and the specific role of these trace elements on neonatal myelinated white matter-a key marker of brain maturation. This population-based study included 93 neonates recruited from three major hospitals in Barcelona (2018-2021). PM2.5 exposure was estimated for the embryonic and late fetal periods using land-use regression models incorporating time-weighted maternal mobility data. MRI was performed at 29 days postnatally. Global myelinated white matter was manually segmented, and automated cortical myelination measures were obtained in 85 cases. Associations were examined using linear regression models with and without adjustment for potential confounders. Higher prenatal PM2.5 exposure was associated with lower myelinated white matter content. Trace elements showed a similar pattern, but their associations became nonsignificant after adjusting for overall PM2.5 exposure. The findings suggest that prenatal air pollution exposure may delay early myelination. Moreover, no specific associations were identified for iron, copper, or zinc. However, given the dynamic nature of white matter maturation, such delays may not necessarily be detrimental. This study underscores the impact of environmental factors on neonatal brain development and the importance of stringent air quality policies, while emphasizing the need for longitudinal research to assess long-term cognitive and behavioral outcomes.The AirNB project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (AirNB projectERC- Advanced Grants 2018, agreement 785994). We would like to thank all the participants and their families for their generous collaboration. Thanks to all the researchers who work with the Mother-Child Barcelona Life Study Cohort- BiSC umbrella project. A full list of BiSC researchers can be found at https://projectebisc.org/en/team/. We extend our acknowledgment to the Health Effects Institute (4959-RFA17-1/18-1 – FRONTIER project); H2020 -EU.3.1.2. (874583 - ATHLETE project), H2020-EU.3.1.1. (GA964827 – AURORA project), the Marie Skłodowska-Curie grant agreement (886121); Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (2019/01/039 - HyPAXE project), AXA Research Fund (MOOD-COVID project), the Instituto de Salud Carlos III and the European Regional Development Fund - Maternal and Child Health and Development Network (RD16/0022/0014 and RD16/0022/0015), the AGAUR-Agència de Gestió d'Ajuts Universitaris de Recerca (2021 SGR 01570 - Population Neuroscience group), the Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CB06/02/0041), and the Instituto de Salud Carlos III and the European Union Next Generation EU - Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RD21/0012/0001 and RD21/0012/0003) for funding the umbrella BiSC cohort. The authors thank the iBEAT V2.0 Cloud group at the University of North Carolina for their assistance with the analysis (DOIs: 10.1007/978-3-030-00931-1_47, 10.1016/j.neuroimage.2013.12.038, 10.1016/j.media.2015.04.005, 10.1016/j.neuroimage.2018.03.042). Gerard Martínez-Vilavella thanks the Department of Clinical and Health Psychology at the Autonomous University of Barcelona for its assistance during his PhD.Peer reviewedElsevierEuropean Commission0000-0001-8948-49180000-0002-5929-84090000-0002-4743-619X0000-0003-2329-18510000-0003-4537-84720000-0003-4450-41230000-0002-2602-4110Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/401763https://api.elsevier.com/content/abstract/scopus_id/105016638318reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/785994info:eu-repo/grantAgreement/EC/H2020/886121info:eu-repo/grantAgreement/EC/H2020/874583Environment internationalhttps://doi.org/10.1016/j.envint.2025.109801Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4017632026-05-22T06:33:51Z |
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