Clinical utility of urinary gluten immunogenic peptides in the follow-up of patients with coeliac disease

[Background] Gluten-free diet (GFD) is the only treatment for patients with coeliac disease (CD) and its compliance should be monitored to avoid cumulative damage.

Bibliographic Details
Authors: Garzón-Benavides, Marta, Ruiz-Carnicer, Ángela, Segura, Verónica, Fombuena, Blanca, García-Fernández, Francisco José, Sobrino-Rodríguez, Salvador, Gómez Izquierdo, Lourdes, Montes-Cano, Marco-Antonio, Millán Domínguez, Raquel, Rico, María Carmen, González-Naranjo, Carmen, Bozada-García, Juan M., Coronel Rodríguez, Cristóbal, Espín, Beatriz, Díaz, Jacobo, Comino, Isabel, Argüelles Arias, Federico, Cebolla, Ángel, Romero-Gómez, Manuel, Rodríguez-Herrera, Alfonso, Sousa, Carolina, Pizarro, Ángeles
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/334070
Online Access:http://hdl.handle.net/10261/334070
https://api.elsevier.com/content/abstract/scopus_id/85150520877
Access Level:Open access
Keyword:Urine
Coeliac disease
Duodenal mucosal damage
Gluten immunogenic peptides
Gluten-free diet
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spelling Clinical utility of urinary gluten immunogenic peptides in the follow-up of patients with coeliac diseaseGarzón-Benavides, MartaRuiz-Carnicer, ÁngelaSegura, VerónicaFombuena, BlancaGarcía-Fernández, Francisco JoséSobrino-Rodríguez, SalvadorGómez Izquierdo, LourdesMontes-Cano, Marco-AntonioMillán Domínguez, RaquelRico, María CarmenGonzález-Naranjo, CarmenBozada-García, Juan M.Coronel Rodríguez, CristóbalEspín, BeatrizDíaz, JacoboComino, IsabelArgüelles Arias, FedericoCebolla, ÁngelRomero-Gómez, ManuelRodríguez-Herrera, AlfonsoSousa, CarolinaPizarro, ÁngelesUrineCoeliac diseaseDuodenal mucosal damageGluten immunogenic peptidesGluten-free diet[Background] Gluten-free diet (GFD) is the only treatment for patients with coeliac disease (CD) and its compliance should be monitored to avoid cumulative damage.[Aims] To analyse gluten exposures of coeliac patients on GFD for at least 24 months using different monitoring tools and its impact on duodenal histology at 12-month follow-up and evaluate the interval of determination of urinary gluten immunogenic peptides (u-GIP) for the monitoring of GFD adherence.[Methods] Ninety-four patients with CD on a GFD for at least 24 months were prospectively included. Symptoms, serology, CDAT questionnaire, and u-GIP (three samples/visit) were analysed at inclusion, 3, 6, and 12 months. Duodenal biopsy was performed at inclusion and 12 months.[Results] At inclusion, 25.8% presented duodenal mucosal damage; at 12 months, this percentage reduced by half. This histological improvement was indicated by a reduction in u-GIP but did not correlate with the remaining tools. The determination of u-GIP detected a higher number of transgressions than serology, regardless of histological evolution type. The presence of >4 u-GIP-positive samples out of 12 collected during 12 months predicted histological lesion with a specificity of 93%. Most patients (94%) with negative u-GIP in ≥2 follow-up visits showed the absence of histological lesions (p < 0.05).[Conclusion] This study suggests that the frequency of recurrent gluten exposures, according to serial determination of u-GIP, could be related to the persistence of villous atrophy and that a more regular follow-up every 6 months, instead of annually, provides more useful data about the adequate adherence to GFD and mucosal healing.This study was funded in part by Fundación Progreso y Salud, Consejería de Salud, Junta de Andalucía (PI-0427-2017 and PI-0053-2018).Peer reviewedJohn Wiley & SonsFundación Progreso y SaludJunta de AndalucíaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/334070https://api.elsevier.com/content/abstract/scopus_id/85150520877reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1111/apt.17417https://doi.org/10.1111/apt.17417Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3340702026-05-22T06:33:51Z
dc.title.none.fl_str_mv Clinical utility of urinary gluten immunogenic peptides in the follow-up of patients with coeliac disease
title Clinical utility of urinary gluten immunogenic peptides in the follow-up of patients with coeliac disease
spellingShingle Clinical utility of urinary gluten immunogenic peptides in the follow-up of patients with coeliac disease
Garzón-Benavides, Marta
Urine
Coeliac disease
Duodenal mucosal damage
Gluten immunogenic peptides
Gluten-free diet
title_short Clinical utility of urinary gluten immunogenic peptides in the follow-up of patients with coeliac disease
title_full Clinical utility of urinary gluten immunogenic peptides in the follow-up of patients with coeliac disease
title_fullStr Clinical utility of urinary gluten immunogenic peptides in the follow-up of patients with coeliac disease
title_full_unstemmed Clinical utility of urinary gluten immunogenic peptides in the follow-up of patients with coeliac disease
title_sort Clinical utility of urinary gluten immunogenic peptides in the follow-up of patients with coeliac disease
dc.creator.none.fl_str_mv Garzón-Benavides, Marta
Ruiz-Carnicer, Ángela
Segura, Verónica
Fombuena, Blanca
García-Fernández, Francisco José
Sobrino-Rodríguez, Salvador
Gómez Izquierdo, Lourdes
Montes-Cano, Marco-Antonio
Millán Domínguez, Raquel
Rico, María Carmen
González-Naranjo, Carmen
Bozada-García, Juan M.
Coronel Rodríguez, Cristóbal
Espín, Beatriz
Díaz, Jacobo
Comino, Isabel
Argüelles Arias, Federico
Cebolla, Ángel
Romero-Gómez, Manuel
Rodríguez-Herrera, Alfonso
Sousa, Carolina
Pizarro, Ángeles
author Garzón-Benavides, Marta
author_facet Garzón-Benavides, Marta
Ruiz-Carnicer, Ángela
Segura, Verónica
Fombuena, Blanca
García-Fernández, Francisco José
Sobrino-Rodríguez, Salvador
Gómez Izquierdo, Lourdes
Montes-Cano, Marco-Antonio
Millán Domínguez, Raquel
Rico, María Carmen
González-Naranjo, Carmen
Bozada-García, Juan M.
Coronel Rodríguez, Cristóbal
Espín, Beatriz
Díaz, Jacobo
Comino, Isabel
Argüelles Arias, Federico
Cebolla, Ángel
Romero-Gómez, Manuel
Rodríguez-Herrera, Alfonso
Sousa, Carolina
Pizarro, Ángeles
author_role author
author2 Ruiz-Carnicer, Ángela
Segura, Verónica
Fombuena, Blanca
García-Fernández, Francisco José
Sobrino-Rodríguez, Salvador
Gómez Izquierdo, Lourdes
Montes-Cano, Marco-Antonio
Millán Domínguez, Raquel
Rico, María Carmen
González-Naranjo, Carmen
Bozada-García, Juan M.
Coronel Rodríguez, Cristóbal
Espín, Beatriz
Díaz, Jacobo
Comino, Isabel
Argüelles Arias, Federico
Cebolla, Ángel
Romero-Gómez, Manuel
Rodríguez-Herrera, Alfonso
Sousa, Carolina
Pizarro, Ángeles
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fundación Progreso y Salud
Junta de Andalucía
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Urine
Coeliac disease
Duodenal mucosal damage
Gluten immunogenic peptides
Gluten-free diet
topic Urine
Coeliac disease
Duodenal mucosal damage
Gluten immunogenic peptides
Gluten-free diet
description [Background] Gluten-free diet (GFD) is the only treatment for patients with coeliac disease (CD) and its compliance should be monitored to avoid cumulative damage.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/334070
https://api.elsevier.com/content/abstract/scopus_id/85150520877
url http://hdl.handle.net/10261/334070
https://api.elsevier.com/content/abstract/scopus_id/85150520877
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1111/apt.17417
https://doi.org/10.1111/apt.17417
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414665761587200
score 15.81155

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