The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease

The placenta is a central structure in pregnancy and has pleiotropic functions. This organ grows incredibly rapidly during this period, acting as a mastermind behind different fetal and maternal processes. The relevance of the placenta extends far beyond the pregnancy, being crucial for fetal progra...

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Detalles Bibliográficos
Autores: Ortega, Miguel A., Fraile Martínez, Oscar, García Montero, Cielo, Sáez García, Miguel Ángel, Álvarez Mon, Miguel Ángel, Torres Carranza, Diego, Álvarez Mon, Melchor, Bujan, Julia, García Honduvilla, Natalio, Bravo Arribas, Coral, Guijarro, Luis G., León Luis, Juan Antonio
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/73357
Acceso en línea:https://hdl.handle.net/20.500.14352/73357
Access Level:acceso abierto
Palabra clave:618.2
Placenta
Preeclampsia
Fetal growth restriction
Maternal chronic venous disease (CVeD)
Medicina
Ginecología y obstetricia
32 Ciencias Médicas
3201.08 Ginecología
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network_acronym_str ES
network_name_str España
repository_id_str
spelling The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous DiseaseOrtega, Miguel A.Fraile Martínez, OscarGarcía Montero, CieloSáez García, Miguel ÁngelÁlvarez Mon, Miguel ÁngelTorres Carranza, DiegoÁlvarez Mon, MelchorBujan, JuliaGarcía Honduvilla, NatalioBravo Arribas, CoralGuijarro, Luis G.León Luis, Juan Antonio618.2PlacentaPreeclampsiaFetal growth restrictionMaternal chronic venous disease (CVeD)MedicinaGinecología y obstetricia32 Ciencias Médicas3201.08 GinecologíaThe placenta is a central structure in pregnancy and has pleiotropic functions. This organ grows incredibly rapidly during this period, acting as a mastermind behind different fetal and maternal processes. The relevance of the placenta extends far beyond the pregnancy, being crucial for fetal programming before birth. Having integrative knowledge of this maternofetal structure helps significantly in understanding the development of pregnancy either in a proper or pathophysiological context. Thus, the aim of this review is to summarize the main features of the placenta, with a special focus on its early development, cytoarchitecture, immunology, and functions in non-pathological conditions. In contraposition, the role of the placenta is examined in preeclampsia, a worrisome hypertensive disorder of pregnancy, in order to describe the pathophysiological implications of the placenta in this disease. Likewise, dysfunction of the placenta in fetal growth restriction, a major consequence of preeclampsia, is also discussed, emphasizing the potential clinical strategies derived. Finally, the emerging role of the placenta in maternal chronic venous disease either as a causative agent or as a consequence of the disease is equally treated.MDPIUniversidad Complutense de Madrid20222022-02-0620222022-02-06journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/73357reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/733572026-06-02T12:44:21Z
dc.title.none.fl_str_mv The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease
title The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease
spellingShingle The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease
Ortega, Miguel A.
618.2
Placenta
Preeclampsia
Fetal growth restriction
Maternal chronic venous disease (CVeD)
Medicina
Ginecología y obstetricia
32 Ciencias Médicas
3201.08 Ginecología
title_short The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease
title_full The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease
title_fullStr The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease
title_full_unstemmed The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease
title_sort The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease
dc.creator.none.fl_str_mv Ortega, Miguel A.
Fraile Martínez, Oscar
García Montero, Cielo
Sáez García, Miguel Ángel
Álvarez Mon, Miguel Ángel
Torres Carranza, Diego
Álvarez Mon, Melchor
Bujan, Julia
García Honduvilla, Natalio
Bravo Arribas, Coral
Guijarro, Luis G.
León Luis, Juan Antonio
author Ortega, Miguel A.
author_facet Ortega, Miguel A.
Fraile Martínez, Oscar
García Montero, Cielo
Sáez García, Miguel Ángel
Álvarez Mon, Miguel Ángel
Torres Carranza, Diego
Álvarez Mon, Melchor
Bujan, Julia
García Honduvilla, Natalio
Bravo Arribas, Coral
Guijarro, Luis G.
León Luis, Juan Antonio
author_role author
author2 Fraile Martínez, Oscar
García Montero, Cielo
Sáez García, Miguel Ángel
Álvarez Mon, Miguel Ángel
Torres Carranza, Diego
Álvarez Mon, Melchor
Bujan, Julia
García Honduvilla, Natalio
Bravo Arribas, Coral
Guijarro, Luis G.
León Luis, Juan Antonio
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 618.2
Placenta
Preeclampsia
Fetal growth restriction
Maternal chronic venous disease (CVeD)
Medicina
Ginecología y obstetricia
32 Ciencias Médicas
3201.08 Ginecología
topic 618.2
Placenta
Preeclampsia
Fetal growth restriction
Maternal chronic venous disease (CVeD)
Medicina
Ginecología y obstetricia
32 Ciencias Médicas
3201.08 Ginecología
description The placenta is a central structure in pregnancy and has pleiotropic functions. This organ grows incredibly rapidly during this period, acting as a mastermind behind different fetal and maternal processes. The relevance of the placenta extends far beyond the pregnancy, being crucial for fetal programming before birth. Having integrative knowledge of this maternofetal structure helps significantly in understanding the development of pregnancy either in a proper or pathophysiological context. Thus, the aim of this review is to summarize the main features of the placenta, with a special focus on its early development, cytoarchitecture, immunology, and functions in non-pathological conditions. In contraposition, the role of the placenta is examined in preeclampsia, a worrisome hypertensive disorder of pregnancy, in order to describe the pathophysiological implications of the placenta in this disease. Likewise, dysfunction of the placenta in fetal growth restriction, a major consequence of preeclampsia, is also discussed, emphasizing the potential clinical strategies derived. Finally, the emerging role of the placenta in maternal chronic venous disease either as a causative agent or as a consequence of the disease is equally treated.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-02-06
2022
2022-02-06
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/73357
url https://hdl.handle.net/20.500.14352/73357
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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