Modulation of telomere length by mediterranean diet, caloric restriction, and exercise: results from PREDIMED-Plus study
Telomere length (TL) has been associated with aging and is determined by lifestyle. However, the mechanisms by which a dietary pattern such as the Mediterranean diet (MedDiet) affects TL homeostasis are still unknown. Our aim was to analyse the effect of an energy-restricted MedDiet with physical ac...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/114011 |
| Acceso en línea: | https://hdl.handle.net/10171/114011 |
| Access Level: | acceso abierto |
| Palabra clave: | 8-hydroxydeoxyguanosine (8-OHdG) Mediterranean diet Telomere length |
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Modulation of telomere length by mediterranean diet, caloric restriction, and exercise: results from PREDIMED-Plus studyFernández-de-la-Puente, M. (María)|||/items/71fe95a5-6986-4147-b39c-019fa90c0affHernandez-Alonso, P. (Pablo)|||/items/b0bb2e36-ee56-413f-ba7e-ee8b27263a0eCanudas, Silvia (S.)|||/items/c9a43494-f4e8-4375-8e57-2a69f15ac342Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6Marti-del-Moral, A. (Amelia)|||/items/c62ba83d-ba7d-43aa-944c-3b57a06af670Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6bRazquin-Burillo, C. (Cristina)|||/items/2b900a44-aca0-4449-9167-2756e88fae068-hydroxydeoxyguanosine (8-OHdG)Mediterranean dietTelomere lengthTelomere length (TL) has been associated with aging and is determined by lifestyle. However, the mechanisms by which a dietary pattern such as the Mediterranean diet (MedDiet) affects TL homeostasis are still unknown. Our aim was to analyse the effect of an energy-restricted MedDiet with physical activity promotion (intervention group) versus an unrestricted-caloric MedDiet with no weight-loss advice (control group) on TL and 8-hydroxydeoxyguanosine (8-OHdG) plasma levels. In total, 80 non-diabetic participants with metabolic syndrome were randomly selected from the PREDIMED (PREvención con DIeta MEDiterránea)-Plus-Reus study. TL was measured by a hybridisation method and 8-OHdG levels by ELISA at baseline and after one year of intervention. Linear mixed models (LMM)-raw and after adjusting for potential confounders-were used to examine the associations between TL or 8-OHdG plasma levels by intervention group and/or time. A total of 69 subjects with available DNA samples were included in the analyses. A significant β-coefficient was found for time towards increasing values through the year of follow-up for TL (unadjusted β of 0.740 (95% CI: 0.529 to 0.951), and multivariable model β of 0.700 (95% CI: 0.477 to 0.922)). No significant βs were found, neither for the intervention group nor for the interaction between the intervention group and time. Regarding 8-OHdG plasma levels, no significant βs were found for the intervention group, time, and its interaction. Our results suggest that MedDiet could have an important role in preventing telomere shortening, but calorie restriction and exercise promotion did not provide an additional advantage concerning telomere length after one year of MedDiet intervention.MDPI AGDadun. Depósito Académico Digital Universidad de Navarra20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/114011reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1140112026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Modulation of telomere length by mediterranean diet, caloric restriction, and exercise: results from PREDIMED-Plus study |
| title |
Modulation of telomere length by mediterranean diet, caloric restriction, and exercise: results from PREDIMED-Plus study |
| spellingShingle |
Modulation of telomere length by mediterranean diet, caloric restriction, and exercise: results from PREDIMED-Plus study Fernández-de-la-Puente, M. (María)|||/items/71fe95a5-6986-4147-b39c-019fa90c0aff 8-hydroxydeoxyguanosine (8-OHdG) Mediterranean diet Telomere length |
| title_short |
Modulation of telomere length by mediterranean diet, caloric restriction, and exercise: results from PREDIMED-Plus study |
| title_full |
Modulation of telomere length by mediterranean diet, caloric restriction, and exercise: results from PREDIMED-Plus study |
| title_fullStr |
Modulation of telomere length by mediterranean diet, caloric restriction, and exercise: results from PREDIMED-Plus study |
| title_full_unstemmed |
Modulation of telomere length by mediterranean diet, caloric restriction, and exercise: results from PREDIMED-Plus study |
| title_sort |
Modulation of telomere length by mediterranean diet, caloric restriction, and exercise: results from PREDIMED-Plus study |
| dc.creator.none.fl_str_mv |
Fernández-de-la-Puente, M. (María)|||/items/71fe95a5-6986-4147-b39c-019fa90c0aff Hernandez-Alonso, P. (Pablo)|||/items/b0bb2e36-ee56-413f-ba7e-ee8b27263a0e Canudas, Silvia (S.)|||/items/c9a43494-f4e8-4375-8e57-2a69f15ac342 Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Marti-del-Moral, A. (Amelia)|||/items/c62ba83d-ba7d-43aa-944c-3b57a06af670 Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Razquin-Burillo, C. (Cristina)|||/items/2b900a44-aca0-4449-9167-2756e88fae06 |
| author |
Fernández-de-la-Puente, M. (María)|||/items/71fe95a5-6986-4147-b39c-019fa90c0aff |
| author_facet |
Fernández-de-la-Puente, M. (María)|||/items/71fe95a5-6986-4147-b39c-019fa90c0aff Hernandez-Alonso, P. (Pablo)|||/items/b0bb2e36-ee56-413f-ba7e-ee8b27263a0e Canudas, Silvia (S.)|||/items/c9a43494-f4e8-4375-8e57-2a69f15ac342 Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Marti-del-Moral, A. (Amelia)|||/items/c62ba83d-ba7d-43aa-944c-3b57a06af670 Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Razquin-Burillo, C. (Cristina)|||/items/2b900a44-aca0-4449-9167-2756e88fae06 |
| author_role |
author |
| author2 |
Hernandez-Alonso, P. (Pablo)|||/items/b0bb2e36-ee56-413f-ba7e-ee8b27263a0e Canudas, Silvia (S.)|||/items/c9a43494-f4e8-4375-8e57-2a69f15ac342 Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Marti-del-Moral, A. (Amelia)|||/items/c62ba83d-ba7d-43aa-944c-3b57a06af670 Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Razquin-Burillo, C. (Cristina)|||/items/2b900a44-aca0-4449-9167-2756e88fae06 |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
8-hydroxydeoxyguanosine (8-OHdG) Mediterranean diet Telomere length |
| topic |
8-hydroxydeoxyguanosine (8-OHdG) Mediterranean diet Telomere length |
| description |
Telomere length (TL) has been associated with aging and is determined by lifestyle. However, the mechanisms by which a dietary pattern such as the Mediterranean diet (MedDiet) affects TL homeostasis are still unknown. Our aim was to analyse the effect of an energy-restricted MedDiet with physical activity promotion (intervention group) versus an unrestricted-caloric MedDiet with no weight-loss advice (control group) on TL and 8-hydroxydeoxyguanosine (8-OHdG) plasma levels. In total, 80 non-diabetic participants with metabolic syndrome were randomly selected from the PREDIMED (PREvención con DIeta MEDiterránea)-Plus-Reus study. TL was measured by a hybridisation method and 8-OHdG levels by ELISA at baseline and after one year of intervention. Linear mixed models (LMM)-raw and after adjusting for potential confounders-were used to examine the associations between TL or 8-OHdG plasma levels by intervention group and/or time. A total of 69 subjects with available DNA samples were included in the analyses. A significant β-coefficient was found for time towards increasing values through the year of follow-up for TL (unadjusted β of 0.740 (95% CI: 0.529 to 0.951), and multivariable model β of 0.700 (95% CI: 0.477 to 0.922)). No significant βs were found, neither for the intervention group nor for the interaction between the intervention group and time. Regarding 8-OHdG plasma levels, no significant βs were found for the intervention group, time, and its interaction. Our results suggest that MedDiet could have an important role in preventing telomere shortening, but calorie restriction and exercise promotion did not provide an additional advantage concerning telomere length after one year of MedDiet intervention. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/114011 |
| url |
https://hdl.handle.net/10171/114011 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI AG |
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MDPI AG |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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15.811543 |