Clotting activation and impairment of fibrinolysis in malignancy
Different coagulation and fibrinolysis parameters were investigated in 149 patients with metastatic and non-metastatic tumours and results were compared with those obtained in a healthy population. Results showed a significant increase of thrombin-antithrombin complexes, fibrinopeptide A (FPA) and f...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 1989 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/22345 |
| Acceso en línea: | https://hdl.handle.net/10171/22345 |
| Access Level: | acceso abierto |
| Palabra clave: | Malignancy Thrombosis Clotting activation Fibrinolysis |
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Clotting activation and impairment of fibrinolysis in malignancyRocha, E. (Eduardo)|||/items/96d5cf13-d967-4252-8888-36a4956209d6Páramo-Fernández, J.A. (José Antonio)|||/items/8c56baa6-2a43-4836-b91b-4eed15be3c96Fernandez, F.J. (Francisco J.)|||/items/ad6aab00-962b-4075-a132-cf0626bba145Cuesta, B. (Braulia)|||/items/346a2bd1-5f42-4853-bf55-b53e424b53c6Hernández, M. (M.)|||/items/fe59a0a7-4ae9-4111-aaab-4b72e6326a06Paloma, M.J. (María José)|||/items/b7ced076-3ddc-4430-8dc3-500b85ca0e51Rifón-Roca, J.J. (José Juan)|||/items/0af61dd8-c2c3-4e4b-bcbc-5fbb716ac040MalignancyThrombosisClotting activationFibrinolysisDifferent coagulation and fibrinolysis parameters were investigated in 149 patients with metastatic and non-metastatic tumours and results were compared with those obtained in a healthy population. Results showed a significant increase of thrombin-antithrombin complexes, fibrinopeptide A (FPA) and fibrin monomers in the group of patients (p less than 0.001). There was also a significant prolongation of euglobulin lysis time (p less than 0.005) and an increase of plasminogen activator inhibitor activity (p less than 0.0001), fibrinogen degradation products (p less than 0.001), and D-dimer (p less than 0.05) in the group of patients as compared to controls; FPA levels were also increased in patients with metastases (p less than 0.005). This study demonstrates clotting activation, at the level of fibrinogen to fibrin conversion, and impairment of fibrinolysis in patients with malignancy.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20122012-05-3019891989-01-0119891989-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/22345reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/223452026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Clotting activation and impairment of fibrinolysis in malignancy |
| title |
Clotting activation and impairment of fibrinolysis in malignancy |
| spellingShingle |
Clotting activation and impairment of fibrinolysis in malignancy Rocha, E. (Eduardo)|||/items/96d5cf13-d967-4252-8888-36a4956209d6 Malignancy Thrombosis Clotting activation Fibrinolysis |
| title_short |
Clotting activation and impairment of fibrinolysis in malignancy |
| title_full |
Clotting activation and impairment of fibrinolysis in malignancy |
| title_fullStr |
Clotting activation and impairment of fibrinolysis in malignancy |
| title_full_unstemmed |
Clotting activation and impairment of fibrinolysis in malignancy |
| title_sort |
Clotting activation and impairment of fibrinolysis in malignancy |
| dc.creator.none.fl_str_mv |
Rocha, E. (Eduardo)|||/items/96d5cf13-d967-4252-8888-36a4956209d6 Páramo-Fernández, J.A. (José Antonio)|||/items/8c56baa6-2a43-4836-b91b-4eed15be3c96 Fernandez, F.J. (Francisco J.)|||/items/ad6aab00-962b-4075-a132-cf0626bba145 Cuesta, B. (Braulia)|||/items/346a2bd1-5f42-4853-bf55-b53e424b53c6 Hernández, M. (M.)|||/items/fe59a0a7-4ae9-4111-aaab-4b72e6326a06 Paloma, M.J. (María José)|||/items/b7ced076-3ddc-4430-8dc3-500b85ca0e51 Rifón-Roca, J.J. (José Juan)|||/items/0af61dd8-c2c3-4e4b-bcbc-5fbb716ac040 |
| author |
Rocha, E. (Eduardo)|||/items/96d5cf13-d967-4252-8888-36a4956209d6 |
| author_facet |
Rocha, E. (Eduardo)|||/items/96d5cf13-d967-4252-8888-36a4956209d6 Páramo-Fernández, J.A. (José Antonio)|||/items/8c56baa6-2a43-4836-b91b-4eed15be3c96 Fernandez, F.J. (Francisco J.)|||/items/ad6aab00-962b-4075-a132-cf0626bba145 Cuesta, B. (Braulia)|||/items/346a2bd1-5f42-4853-bf55-b53e424b53c6 Hernández, M. (M.)|||/items/fe59a0a7-4ae9-4111-aaab-4b72e6326a06 Paloma, M.J. (María José)|||/items/b7ced076-3ddc-4430-8dc3-500b85ca0e51 Rifón-Roca, J.J. (José Juan)|||/items/0af61dd8-c2c3-4e4b-bcbc-5fbb716ac040 |
| author_role |
author |
| author2 |
Páramo-Fernández, J.A. (José Antonio)|||/items/8c56baa6-2a43-4836-b91b-4eed15be3c96 Fernandez, F.J. (Francisco J.)|||/items/ad6aab00-962b-4075-a132-cf0626bba145 Cuesta, B. (Braulia)|||/items/346a2bd1-5f42-4853-bf55-b53e424b53c6 Hernández, M. (M.)|||/items/fe59a0a7-4ae9-4111-aaab-4b72e6326a06 Paloma, M.J. (María José)|||/items/b7ced076-3ddc-4430-8dc3-500b85ca0e51 Rifón-Roca, J.J. (José Juan)|||/items/0af61dd8-c2c3-4e4b-bcbc-5fbb716ac040 |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Malignancy Thrombosis Clotting activation Fibrinolysis |
| topic |
Malignancy Thrombosis Clotting activation Fibrinolysis |
| description |
Different coagulation and fibrinolysis parameters were investigated in 149 patients with metastatic and non-metastatic tumours and results were compared with those obtained in a healthy population. Results showed a significant increase of thrombin-antithrombin complexes, fibrinopeptide A (FPA) and fibrin monomers in the group of patients (p less than 0.001). There was also a significant prolongation of euglobulin lysis time (p less than 0.005) and an increase of plasminogen activator inhibitor activity (p less than 0.0001), fibrinogen degradation products (p less than 0.001), and D-dimer (p less than 0.05) in the group of patients as compared to controls; FPA levels were also increased in patients with metastases (p less than 0.005). This study demonstrates clotting activation, at the level of fibrinogen to fibrin conversion, and impairment of fibrinolysis in patients with malignancy. |
| publishDate |
1989 |
| dc.date.none.fl_str_mv |
1989 1989-01-01 1989 1989-01-01 2012 2012-05-30 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/22345 |
| url |
https://hdl.handle.net/10171/22345 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
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Elsevier |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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1869414652202450944 |
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15,300724 |