Potential relation of cardiovascular risk factors to disease activity in patients with axial spondyloarthritis

Background: Axial spondyloarthritis (axSpA) patients are known to have a higher prevalence of several comorbidities, including, among others, an increased risk of atherosclerosis, hypertension, dyslipidemia, and diabetes. The purpose of the present study was to determine whether the sum of tradition...

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Autores: Ferraz-Amaro, I, Rueda-Gotor, J, Genre, F, Corrales, A, Blanco, R, Portilla, V, Mazon, IG, Llorca, J, Exposito, R, Vicente, EF, Quevedo-Abeledo, JC, Rodriguez-Lozano, C, Ortega-Castro, R, Ladehesa-Pineda, ML, Fernandez-Carballido, C, Martinez-Vidal, MP, Castro-Corredor, D, Anino-Fernandez, J, Vivar, MLG, Galindez-Agirregoikoa, E, Peiteado, D, Plasencia-Rodriguez, C, Perez, EM, Diaz, CF, Castaneda, S, Gonzalez-Gay, MA
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositório:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p12093
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/12093
Access Level:Acceso aberto
Palavra-chave:axial spondyloarthritis
cardiovascular risk factors
disease activity
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spelling Potential relation of cardiovascular risk factors to disease activity in patients with axial spondyloarthritisFerraz-Amaro, IRueda-Gotor, JGenre, FCorrales, ABlanco, RPortilla, VMazon, IGLlorca, JExposito, RVicente, EFQuevedo-Abeledo, JCRodriguez-Lozano, COrtega-Castro, RLadehesa-Pineda, MLFernandez-Carballido, CMartinez-Vidal, MPCastro-Corredor, DAnino-Fernandez, JVivar, MLGGalindez-Agirregoikoa, EPeiteado, DPlasencia-Rodriguez, CPerez, EMDiaz, CFCastaneda, SGonzalez-Gay, MAaxial spondyloarthritiscardiovascular risk factorsdisease activityBackground: Axial spondyloarthritis (axSpA) patients are known to have a higher prevalence of several comorbidities, including, among others, an increased risk of atherosclerosis, hypertension, dyslipidemia, and diabetes. The purpose of the present study was to determine whether the sum of traditional cardiovascular (CV) risk factors is related to disease characteristics, such as disease activity, in patients with axSpA. Methods: A cross-sectional study that encompassed 804 patients with axSpA was conducted. Patients were assessed for the presence of five traditional CV risk factors (diabetes mellitus, dyslipidemia, hypertension, obesity, and smoking status), and disease activity measurements. A multivariable regression analysis was performed to evaluate whether the number of classic CV risk factors was independently associated with specific features of the disease, to include disease activity. Results: A multivariable analysis showed that Ankylosing Spondylitis Disease Activity Score-C reactive protein (ASDAS-CRP) activity score was significantly higher in patients with 1 [beta coefficient 0.3 (95% confidence interval (CI) 0.1-0.5), p = 0.001] and > 2 [beta coefficient 0.5 (95% CI 0.3-0.7), p = 0.000] CV risk factors compared with those without CV risk factors. Similarly, patients with 1 [OR 2.00 (95%CI 0.99-4.02), p = 0.053] and > 2 [OR 3.39 (95%CI 1.82-6.31), p = 0.000] CV risk factors had a higher odds ratio for the presence of high disease activity compared with the zero CV category. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) activity score was significantly associated with the number of CV risk factors, being higher in patients with more CV risk factors. These relationships showed a CV risk factor-dependent effect being beta coefficients and ORs higher for the effect of > 2 over 1 CV risk factor. Conclusion: Among patients with axSpA, as the number of traditional CV risk factors increased, disease activity similarly increases in an independent manner.SAGE PUBLICATIONS LTD2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/12093Therapeutic Advances in Musculoskeletal DiseaseISSN: 1759720XISSNe: 17597218reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p120932026-06-11T12:45:17Z
dc.title.none.fl_str_mv Potential relation of cardiovascular risk factors to disease activity in patients with axial spondyloarthritis
title Potential relation of cardiovascular risk factors to disease activity in patients with axial spondyloarthritis
spellingShingle Potential relation of cardiovascular risk factors to disease activity in patients with axial spondyloarthritis
Ferraz-Amaro, I
axial spondyloarthritis
cardiovascular risk factors
disease activity
title_short Potential relation of cardiovascular risk factors to disease activity in patients with axial spondyloarthritis
title_full Potential relation of cardiovascular risk factors to disease activity in patients with axial spondyloarthritis
title_fullStr Potential relation of cardiovascular risk factors to disease activity in patients with axial spondyloarthritis
title_full_unstemmed Potential relation of cardiovascular risk factors to disease activity in patients with axial spondyloarthritis
title_sort Potential relation of cardiovascular risk factors to disease activity in patients with axial spondyloarthritis
dc.creator.none.fl_str_mv Ferraz-Amaro, I
Rueda-Gotor, J
Genre, F
Corrales, A
Blanco, R
Portilla, V
Mazon, IG
Llorca, J
Exposito, R
Vicente, EF
Quevedo-Abeledo, JC
Rodriguez-Lozano, C
Ortega-Castro, R
Ladehesa-Pineda, ML
Fernandez-Carballido, C
Martinez-Vidal, MP
Castro-Corredor, D
Anino-Fernandez, J
Vivar, MLG
Galindez-Agirregoikoa, E
Peiteado, D
Plasencia-Rodriguez, C
Perez, EM
Diaz, CF
Castaneda, S
Gonzalez-Gay, MA
author Ferraz-Amaro, I
author_facet Ferraz-Amaro, I
Rueda-Gotor, J
Genre, F
Corrales, A
Blanco, R
Portilla, V
Mazon, IG
Llorca, J
Exposito, R
Vicente, EF
Quevedo-Abeledo, JC
Rodriguez-Lozano, C
Ortega-Castro, R
Ladehesa-Pineda, ML
Fernandez-Carballido, C
Martinez-Vidal, MP
Castro-Corredor, D
Anino-Fernandez, J
Vivar, MLG
Galindez-Agirregoikoa, E
Peiteado, D
Plasencia-Rodriguez, C
Perez, EM
Diaz, CF
Castaneda, S
Gonzalez-Gay, MA
author_role author
author2 Rueda-Gotor, J
Genre, F
Corrales, A
Blanco, R
Portilla, V
Mazon, IG
Llorca, J
Exposito, R
Vicente, EF
Quevedo-Abeledo, JC
Rodriguez-Lozano, C
Ortega-Castro, R
Ladehesa-Pineda, ML
Fernandez-Carballido, C
Martinez-Vidal, MP
Castro-Corredor, D
Anino-Fernandez, J
Vivar, MLG
Galindez-Agirregoikoa, E
Peiteado, D
Plasencia-Rodriguez, C
Perez, EM
Diaz, CF
Castaneda, S
Gonzalez-Gay, MA
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv axial spondyloarthritis
cardiovascular risk factors
disease activity
topic axial spondyloarthritis
cardiovascular risk factors
disease activity
description Background: Axial spondyloarthritis (axSpA) patients are known to have a higher prevalence of several comorbidities, including, among others, an increased risk of atherosclerosis, hypertension, dyslipidemia, and diabetes. The purpose of the present study was to determine whether the sum of traditional cardiovascular (CV) risk factors is related to disease characteristics, such as disease activity, in patients with axSpA. Methods: A cross-sectional study that encompassed 804 patients with axSpA was conducted. Patients were assessed for the presence of five traditional CV risk factors (diabetes mellitus, dyslipidemia, hypertension, obesity, and smoking status), and disease activity measurements. A multivariable regression analysis was performed to evaluate whether the number of classic CV risk factors was independently associated with specific features of the disease, to include disease activity. Results: A multivariable analysis showed that Ankylosing Spondylitis Disease Activity Score-C reactive protein (ASDAS-CRP) activity score was significantly higher in patients with 1 [beta coefficient 0.3 (95% confidence interval (CI) 0.1-0.5), p = 0.001] and > 2 [beta coefficient 0.5 (95% CI 0.3-0.7), p = 0.000] CV risk factors compared with those without CV risk factors. Similarly, patients with 1 [OR 2.00 (95%CI 0.99-4.02), p = 0.053] and > 2 [OR 3.39 (95%CI 1.82-6.31), p = 0.000] CV risk factors had a higher odds ratio for the presence of high disease activity compared with the zero CV category. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) activity score was significantly associated with the number of CV risk factors, being higher in patients with more CV risk factors. These relationships showed a CV risk factor-dependent effect being beta coefficients and ORs higher for the effect of > 2 over 1 CV risk factor. Conclusion: Among patients with axSpA, as the number of traditional CV risk factors increased, disease activity similarly increases in an independent manner.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/12093
url https://fisabio.portalinvestigacion.com/publicaciones/12093
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SAGE PUBLICATIONS LTD
publisher.none.fl_str_mv SAGE PUBLICATIONS LTD
dc.source.none.fl_str_mv Therapeutic Advances in Musculoskeletal Disease
ISSN: 1759720X
ISSNe: 17597218
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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