Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro

The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function and also regulates growth hormone (GH) secretion in rat adenopituitary cells cultures with the adipokine. Although adipose tissue is the primary sou...

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Autores: Rodriguez Pacheco, Francisca, Garrido Novelle, Marta, Vazquez, María, García Escobar, Eva, Soriguer, Federico, Rojo Martínez, Gemma, García Fuentes, Eduardo, Malagón, María del Mar, Diéguez, Carlos
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/94905
Acceso en línea:https://hdl.handle.net/20.500.14352/94905
Access Level:acceso abierto
Palabra clave:577.17
Bioquímica (Biología)
2415 Biología Molecular
2403 Bioquímica
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spelling Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitroRodriguez Pacheco, FranciscaGarrido Novelle, MartaVazquez, MaríaGarcía Escobar, EvaSoriguer, FedericoRojo Martínez, GemmaGarcía Fuentes, EduardoMalagón, María del MarDiéguez, Carlos577.17Bioquímica (Biología)2415 Biología Molecular2403 BioquímicaThe adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function and also regulates growth hormone (GH) secretion in rat adenopituitary cells cultures with the adipokine. Although adipose tissue is the primary source of resistin, it is also expressed in other tissues, including the pituitary. The aim of this study is to investigate the possible action of resistin on the lipid metabolism in the pituitary gland in vivo (rats in two different nutritional status, fed and fast, treated with resistin on acute and a chronic way) and in vitro (adenopituitary cell cultures treated with the adipokine). Here, by a combination of in vivo and in vitro experimental models, we demonstrated that central acute and chronic administration of resistin enhance mRNA levels of the lipid metabolic enzymes which participated on lipolysis and moreover inhibiting mRNA levels of the lipid metabolic enzymes involved in lipogenesis. Taken together, our results demonstrate for the first time that resistin has a regulatory role on lipid metabolism in the pituitary gland providing a novel insight in relation to the mechanism by which this adipokine can participate in the integrated control of lipid metabolism.WileyUniversidad Complutense de Madrid20132013-01-0120132013-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/94905reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/949052026-06-02T12:44:21Z
dc.title.none.fl_str_mv Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro
title Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro
spellingShingle Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro
Rodriguez Pacheco, Francisca
577.17
Bioquímica (Biología)
2415 Biología Molecular
2403 Bioquímica
title_short Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro
title_full Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro
title_fullStr Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro
title_full_unstemmed Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro
title_sort Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro
dc.creator.none.fl_str_mv Rodriguez Pacheco, Francisca
Garrido Novelle, Marta
Vazquez, María
García Escobar, Eva
Soriguer, Federico
Rojo Martínez, Gemma
García Fuentes, Eduardo
Malagón, María del Mar
Diéguez, Carlos
author Rodriguez Pacheco, Francisca
author_facet Rodriguez Pacheco, Francisca
Garrido Novelle, Marta
Vazquez, María
García Escobar, Eva
Soriguer, Federico
Rojo Martínez, Gemma
García Fuentes, Eduardo
Malagón, María del Mar
Diéguez, Carlos
author_role author
author2 Garrido Novelle, Marta
Vazquez, María
García Escobar, Eva
Soriguer, Federico
Rojo Martínez, Gemma
García Fuentes, Eduardo
Malagón, María del Mar
Diéguez, Carlos
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 577.17
Bioquímica (Biología)
2415 Biología Molecular
2403 Bioquímica
topic 577.17
Bioquímica (Biología)
2415 Biología Molecular
2403 Bioquímica
description The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function and also regulates growth hormone (GH) secretion in rat adenopituitary cells cultures with the adipokine. Although adipose tissue is the primary source of resistin, it is also expressed in other tissues, including the pituitary. The aim of this study is to investigate the possible action of resistin on the lipid metabolism in the pituitary gland in vivo (rats in two different nutritional status, fed and fast, treated with resistin on acute and a chronic way) and in vitro (adenopituitary cell cultures treated with the adipokine). Here, by a combination of in vivo and in vitro experimental models, we demonstrated that central acute and chronic administration of resistin enhance mRNA levels of the lipid metabolic enzymes which participated on lipolysis and moreover inhibiting mRNA levels of the lipid metabolic enzymes involved in lipogenesis. Taken together, our results demonstrate for the first time that resistin has a regulatory role on lipid metabolism in the pituitary gland providing a novel insight in relation to the mechanism by which this adipokine can participate in the integrated control of lipid metabolism.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01
2013
2013-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/94905
url https://hdl.handle.net/20.500.14352/94905
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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