Increased obesity-associated circulating levels of the extracellular matrix proteins Osteopontin, Chitinase-3 Like-1 and Tenascin C are associated with colon cancer

Excess adipose tissue represents a major risk factor for the development of colon cancer with inflammation and extracellular matrix (ECM) remodeling being proposed as plausible mechanisms. The aim of this study was to investigate whether obesity can influence circulating levels of inflammation-relat...

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Authors: Catalán-Goñi, V. (Victoria)|||/items/9a5a055c-323a-4b41-800f-65abf7f22c79, Gomez-Ambrosi, J. (Javier)|||/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8e, Rodriguez, A. (Amaia)|||/items/50976a5f-9842-47f1-8a9c-508e59996427, Ramirez-Sola, B. (Beatriz)|||/items/95970833-a061-4e49-b5d8-e6ecc6ec59c4, Izaguirre, M. (Maitane)|||/items/b1ef9430-ad86-441d-8789-a92f881a166a, Hernandez-Lizoain, J.L. (Jose Luis)|||/items/57a38c27-cc3f-4081-866c-d2287fccaac2, Baixauli-Fons, J. (Jorge)|||/items/c863985d-f450-4807-a4fe-56d26f6e8dfa, Marti-Cruchaga, P. (Pablo)|||/items/97577c37-4c78-4a17-8b03-55eec0b40ff9, Valenti-Azcarate, V. (Víctor)|||/items/43ffa5b1-000e-4670-8fa2-4ab80d1960d7, Moncada, R. (Rafael)|||/items/2675adbe-8b28-4af8-b1d6-baa3319591bc, Silva-Frojan, C. (Camilo)|||/items/4037daf2-cf27-42c3-b76c-2ad9aa9465ef, Salvador-Rodríguez, F.J. (Francisco Javier)|||/items/1175815b-412b-41a6-b91f-6dbfa349f9c8, Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b
Format: article
Publication Date:2016
Country:España
Institution:Universidad de Navarra
Repository:Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:English
OAI Identifier:oai:dadun.unav.edu:10171/41859
Online Access:https://hdl.handle.net/10171/41859
Access Level:Open access
Keyword:Obesity
Colon Cancer
Excess adipose tissue
Materias Investigacion::Ciencias de la Salud::Endocrinología
Materias Investigacion::Ciencias de la Salud::Nutrición y dietética
Description
Summary:Excess adipose tissue represents a major risk factor for the development of colon cancer with inflammation and extracellular matrix (ECM) remodeling being proposed as plausible mechanisms. The aim of this study was to investigate whether obesity can influence circulating levels of inflammation-related extracellular matrix proteins in patients with colon cancer (CC), promoting a microenvironment favorable for tumor growth. Methods Serum samples obtained from 79 subjects [26 lean (LN) and 53 obese (OB)] were used in the study. Enrolled subjects were further subclassified according to the established diagnostic protocol for CC (44 without CC and 35 with CC). Anthropometricmeasurements as well as circulating metabolites and hormoneswere determined. Circulating concentrations of the ECM proteins osteopontin (OPN), chitinase-3-like protein 1 (YKL-40), tenascin C (TNC) and lipocalin-2 (LCN-2) were determined by ELISA. Results Significant differences in circulating OPN, YKL-40 and TNC concentrations between the experimental groups were observed, being significantly increased due to obesity (P<0.01) and colon cancer (P<0.05). LCN-2 levels were affected by obesity (P<0.05), but no differences were detected regarding the presence or not of CC. A positive association (P<0.05) with different inflammatorymarkers was also detected.Conclusions To our knowledge, we herein show for the first time that obese patients with CC exhibit increased circulating levels of OPN, YKL-40 and TNC providing furtherevidence for the influence of obesity on CC development via ECM proteins, representing promising diagnostic biomarkers or target molecules for therapeutics.

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