Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development

Emerging evidence points to coordinated action of chemical and mechanical cues during brain development. At early stages of neocortical development, angiogenic factors and chemokines such as CXCL12, ephrins, and semaphorins assume crucial roles in orchestrating neuronal migration and axon elongation...

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Autores: López Mengual, Ana, Segura Feliu, Miriam, Sunyer, Raimon, Sanz Fraile, Héctor, Otero Díaz, Jorge, Mesquida Veny, Francina, Gil Fernández, Vanessa, Hervera Abad, Arnau, Ferrer, Isidro (Ferrer Abizanda), Soriano i Fradera, Jordi, Trepat Guixer, Xavier, Farré Ventura, Ramon, Navajas Navarro, Daniel, Río Fernández, José Antonio del
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/187028
Acesso em linha:https://hdl.handle.net/2445/187028
Access Level:acceso abierto
Palavra-chave:Neurobiologia del desenvolupament
Cervell
Developmental neurobiology
Brain
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spelling Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical DevelopmentLópez Mengual, AnaSegura Feliu, MiriamSunyer, RaimonSanz Fraile, HéctorOtero Díaz, JorgeMesquida Veny, FrancinaGil Fernández, VanessaHervera Abad, ArnauFerrer, Isidro (Ferrer Abizanda)Soriano i Fradera, JordiTrepat Guixer, XavierFarré Ventura, RamonNavajas Navarro, DanielRío Fernández, José Antonio delNeurobiologia del desenvolupamentCervellDevelopmental neurobiologyBrainEmerging evidence points to coordinated action of chemical and mechanical cues during brain development. At early stages of neocortical development, angiogenic factors and chemokines such as CXCL12, ephrins, and semaphorins assume crucial roles in orchestrating neuronal migration and axon elongation of postmitotic neurons. Here we explore the intrinsic mechanical properties of the developing marginal zone of the pallium in the migratory pathways and brain distribution of the pioneer Cajal-Retzius cells. These neurons are generated in several proliferative regions in the developing brain (e.g., the cortical hem and the pallial subpallial boundary) and migrate tangentially in the preplate/marginal zone covering the upper portion of the developing cortex. These cells play crucial roles in correct neocortical layer formation by secreting several molecules such as Reelin. Our results indicate that the motogenic properties of Cajal-Retzius cells and their perinatal distribution in the marginal zone are modulated by both chemical and mechanical factors, by the specific mechanical properties of Cajal-Retzius cells, and by the differential stiffness of the migratory routes. Indeed, cells originating in the cortical hem display higher migratory capacities than those generated in the pallial subpallial boundary which may be involved in the differential distribution of these cells in the dorsal-lateral axis in the developing marginal zone.Frontiers Media2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion16 p.application/pdfhttps://hdl.handle.net/2445/187028Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fcell.2022.886110Frontiers in Cell and Developmental Biology, 2022, vol. 10https://doi.org/10.3389/fcell.2022.886110cc by (c) López Mengual, Ana et al, 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1870282026-05-29T05:05:01Z
dc.title.none.fl_str_mv Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development
title Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development
spellingShingle Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development
López Mengual, Ana
Neurobiologia del desenvolupament
Cervell
Developmental neurobiology
Brain
title_short Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development
title_full Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development
title_fullStr Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development
title_full_unstemmed Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development
title_sort Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development
dc.creator.none.fl_str_mv López Mengual, Ana
Segura Feliu, Miriam
Sunyer, Raimon
Sanz Fraile, Héctor
Otero Díaz, Jorge
Mesquida Veny, Francina
Gil Fernández, Vanessa
Hervera Abad, Arnau
Ferrer, Isidro (Ferrer Abizanda)
Soriano i Fradera, Jordi
Trepat Guixer, Xavier
Farré Ventura, Ramon
Navajas Navarro, Daniel
Río Fernández, José Antonio del
author López Mengual, Ana
author_facet López Mengual, Ana
Segura Feliu, Miriam
Sunyer, Raimon
Sanz Fraile, Héctor
Otero Díaz, Jorge
Mesquida Veny, Francina
Gil Fernández, Vanessa
Hervera Abad, Arnau
Ferrer, Isidro (Ferrer Abizanda)
Soriano i Fradera, Jordi
Trepat Guixer, Xavier
Farré Ventura, Ramon
Navajas Navarro, Daniel
Río Fernández, José Antonio del
author_role author
author2 Segura Feliu, Miriam
Sunyer, Raimon
Sanz Fraile, Héctor
Otero Díaz, Jorge
Mesquida Veny, Francina
Gil Fernández, Vanessa
Hervera Abad, Arnau
Ferrer, Isidro (Ferrer Abizanda)
Soriano i Fradera, Jordi
Trepat Guixer, Xavier
Farré Ventura, Ramon
Navajas Navarro, Daniel
Río Fernández, José Antonio del
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neurobiologia del desenvolupament
Cervell
Developmental neurobiology
Brain
topic Neurobiologia del desenvolupament
Cervell
Developmental neurobiology
Brain
description Emerging evidence points to coordinated action of chemical and mechanical cues during brain development. At early stages of neocortical development, angiogenic factors and chemokines such as CXCL12, ephrins, and semaphorins assume crucial roles in orchestrating neuronal migration and axon elongation of postmitotic neurons. Here we explore the intrinsic mechanical properties of the developing marginal zone of the pallium in the migratory pathways and brain distribution of the pioneer Cajal-Retzius cells. These neurons are generated in several proliferative regions in the developing brain (e.g., the cortical hem and the pallial subpallial boundary) and migrate tangentially in the preplate/marginal zone covering the upper portion of the developing cortex. These cells play crucial roles in correct neocortical layer formation by secreting several molecules such as Reelin. Our results indicate that the motogenic properties of Cajal-Retzius cells and their perinatal distribution in the marginal zone are modulated by both chemical and mechanical factors, by the specific mechanical properties of Cajal-Retzius cells, and by the differential stiffness of the migratory routes. Indeed, cells originating in the cortical hem display higher migratory capacities than those generated in the pallial subpallial boundary which may be involved in the differential distribution of these cells in the dorsal-lateral axis in the developing marginal zone.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/187028
url https://hdl.handle.net/2445/187028
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fcell.2022.886110
Frontiers in Cell and Developmental Biology, 2022, vol. 10
https://doi.org/10.3389/fcell.2022.886110
dc.rights.none.fl_str_mv cc by (c) López Mengual, Ana et al, 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) López Mengual, Ana et al, 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16 p.
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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