Modelado de la influencia del ciclo menstrual en el sistema glucosa-insulina en individuas sanas
[EN] Different studies have shown that insulin sensitivity fluctuates during the luteal and follicular phase of the menstrual cycle and can generate alterations in the behavior of the glucose level. Knowing the correlation between the menstrual cycle phases and the insulin resistance is a main goal...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | español |
| OAI Identifier: | oai:riunet.upv.es:10251/201507 |
| Acceso en línea: | https://riunet.upv.es/handle/10251/201507 |
| Access Level: | acceso abierto |
| Palabra clave: | Diabetes Mellitus Dinámica glucosa-insulina Ciclo menstrual Modelo matemático Mathematical model Glucose-insulin dynamics Menstrual cycle |
| Sumario: | [EN] Different studies have shown that insulin sensitivity fluctuates during the luteal and follicular phase of the menstrual cycle and can generate alterations in the behavior of the glucose level. Knowing the correlation between the menstrual cycle phases and the insulin resistance is a main goal looking forward to improving life quality in diabetic patients. In this research proposes a modification to the mathematical model developed by Dalla Man et al. (Dalla Man, C., Rizza, R. A., & Cobelli, C., 2007) to include the different stages of the menstrual cycle on the behavior of the blood glucose level, taking into account changes in insulin sensitivity and the baseline blood glucose. To verify the behavior of the glucose level during the menstrual cycle described in the literature, a glucose tolerance test was performed in a healthy regularly menstruating subject and compared with in-vitro simulation results. The results allowed us to observe the behavior described in the proposed model by relating the different phases of the menstrual cycle and insulin resistance. |
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