Chagas Disease-Related Mortality in Spain, 1997 to 2018.

BACKGROUND: Chagas disease (CD) is associated with excess mortality in infected people in endemic countries, but little information is available in non-endemic countries. The aim of the study was to analyze mortality in patients admitted to the hospital with CD in Spain. METHODS: A retrospective, ob...

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Autores: Ramos-Rincon JM, Llenas-García J, Pinargote-Celorio H, Sánchez-García V, Wikman-Jorgensen P, Navarro M, Gil-Anguita C, Ramos-Sesma V, Torrus-Tendero D
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p11006
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/11006
Access Level:acceso abierto
Palabra clave:Chagas disease
HIV infection
Spain
aged
cardiopathy
female
male
mortality
neoplasm
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spelling Chagas Disease-Related Mortality in Spain, 1997 to 2018.Ramos-Rincon JMLlenas-García JPinargote-Celorio HSánchez-García VWikman-Jorgensen PNavarro MGil-Anguita CRamos-Sesma VTorrus-Tendero DChagas diseaseHIV infectionSpainagedcardiopathyfemalemalemortalityneoplasmBACKGROUND: Chagas disease (CD) is associated with excess mortality in infected people in endemic countries, but little information is available in non-endemic countries. The aim of the study was to analyze mortality in patients admitted to the hospital with CD in Spain. METHODS: A retrospective, observational study using the Spanish National Hospital Discharge Database. We used the CD diagnostic codes of the 9th and 10th International Classification of Diseases to retrieve CD cases from the national public registry from 1997 to 2018. RESULTS: Of the 5022 hospital admissions in people with CD, there were 56 deaths (case fatality rate (CFR) 1.1%, 95% confidence interval (CI) 0.8%, 1.4%), 20 (35.7%) of which were considered directly related to CD. The median age was higher in those who died (54.5 vs. 38 years; p < 0.001). The CFR increased with age, peaking in the 70-79-year (7.9%, odds ratio (OR) 6.27, 95% CI 1.27, 30.90) and 80-89-year (16.7%, OR 14.7, 95% CI 2.70, 79.90) age groups. Men comprised a higher proportion of those who died compared to survivors (50% vs. 22.6%; p < 0.001). Non-survivors were more likely to have neoplasms (19.6% vs. 3.4%; p < 0.001), heart failure (17.9% vs. 7.2%; p = 0.002), diabetes (12.5% vs. 3.7%; p = 0.001), chronic kidney failure (8.9% vs. 1.6%; p < 0.001), and HIV (8.9% vs. 0.8%; p < 0.001). In the multivariable analysis, the variables associated with mortality were age (adjusted OR (aOR) 1.05; 95% CI: 1.03, 1.07), male sex (aOR 1.79, 95% CI 1.03, 3.14), cancer (aOR: 4.84, 95% CI 2.13, 11.22), and HIV infection (aOR 14.10 95% CI 4.88, 40.73). CONCLUSIONS: The case fatality rate of CD hospitalization was about 1%. The mortality risk increased with age, male sex, cancer, and HIV infection.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/11006MicroorganismsISSN: 20762607reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p110062026-06-11T12:45:17Z
dc.title.none.fl_str_mv Chagas Disease-Related Mortality in Spain, 1997 to 2018.
title Chagas Disease-Related Mortality in Spain, 1997 to 2018.
spellingShingle Chagas Disease-Related Mortality in Spain, 1997 to 2018.
Ramos-Rincon JM
Chagas disease
HIV infection
Spain
aged
cardiopathy
female
male
mortality
neoplasm
title_short Chagas Disease-Related Mortality in Spain, 1997 to 2018.
title_full Chagas Disease-Related Mortality in Spain, 1997 to 2018.
title_fullStr Chagas Disease-Related Mortality in Spain, 1997 to 2018.
title_full_unstemmed Chagas Disease-Related Mortality in Spain, 1997 to 2018.
title_sort Chagas Disease-Related Mortality in Spain, 1997 to 2018.
dc.creator.none.fl_str_mv Ramos-Rincon JM
Llenas-García J
Pinargote-Celorio H
Sánchez-García V
Wikman-Jorgensen P
Navarro M
Gil-Anguita C
Ramos-Sesma V
Torrus-Tendero D
author Ramos-Rincon JM
author_facet Ramos-Rincon JM
Llenas-García J
Pinargote-Celorio H
Sánchez-García V
Wikman-Jorgensen P
Navarro M
Gil-Anguita C
Ramos-Sesma V
Torrus-Tendero D
author_role author
author2 Llenas-García J
Pinargote-Celorio H
Sánchez-García V
Wikman-Jorgensen P
Navarro M
Gil-Anguita C
Ramos-Sesma V
Torrus-Tendero D
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chagas disease
HIV infection
Spain
aged
cardiopathy
female
male
mortality
neoplasm
topic Chagas disease
HIV infection
Spain
aged
cardiopathy
female
male
mortality
neoplasm
description BACKGROUND: Chagas disease (CD) is associated with excess mortality in infected people in endemic countries, but little information is available in non-endemic countries. The aim of the study was to analyze mortality in patients admitted to the hospital with CD in Spain. METHODS: A retrospective, observational study using the Spanish National Hospital Discharge Database. We used the CD diagnostic codes of the 9th and 10th International Classification of Diseases to retrieve CD cases from the national public registry from 1997 to 2018. RESULTS: Of the 5022 hospital admissions in people with CD, there were 56 deaths (case fatality rate (CFR) 1.1%, 95% confidence interval (CI) 0.8%, 1.4%), 20 (35.7%) of which were considered directly related to CD. The median age was higher in those who died (54.5 vs. 38 years; p < 0.001). The CFR increased with age, peaking in the 70-79-year (7.9%, odds ratio (OR) 6.27, 95% CI 1.27, 30.90) and 80-89-year (16.7%, OR 14.7, 95% CI 2.70, 79.90) age groups. Men comprised a higher proportion of those who died compared to survivors (50% vs. 22.6%; p < 0.001). Non-survivors were more likely to have neoplasms (19.6% vs. 3.4%; p < 0.001), heart failure (17.9% vs. 7.2%; p = 0.002), diabetes (12.5% vs. 3.7%; p = 0.001), chronic kidney failure (8.9% vs. 1.6%; p < 0.001), and HIV (8.9% vs. 0.8%; p < 0.001). In the multivariable analysis, the variables associated with mortality were age (adjusted OR (aOR) 1.05; 95% CI: 1.03, 1.07), male sex (aOR 1.79, 95% CI 1.03, 3.14), cancer (aOR: 4.84, 95% CI 2.13, 11.22), and HIV infection (aOR 14.10 95% CI 4.88, 40.73). CONCLUSIONS: The case fatality rate of CD hospitalization was about 1%. The mortality risk increased with age, male sex, cancer, and HIV infection.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/11006
url https://fisabio.portalinvestigacion.com/publicaciones/11006
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Microorganisms
ISSN: 20762607
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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