Purinergic signaling in endometriosis-associated pain

Endometriosis is an estrogen-dependent gynecological disease, with an associated chronic inflammatory component, characterized by the presence of endometrial tissue outside the uterine cavity. Its predominant symptom is pain, a condition notably altering the quality of life of women with the disease...

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Detalles Bibliográficos
Autores: Trapero, Carla, Martín Satué, Mireia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/183725
Acceso en línea:https://hdl.handle.net/2445/183725
Access Level:acceso abierto
Palabra clave:Endometriosi
Adenosina
Dolor
Inflamació
Endometriosis
Adenosine
Pain
Inflammation
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spelling Purinergic signaling in endometriosis-associated painTrapero, CarlaMartín Satué, MireiaEndometriosiAdenosinaDolorInflamacióEndometriosisAdenosinePainInflammationEndometriosis is an estrogen-dependent gynecological disease, with an associated chronic inflammatory component, characterized by the presence of endometrial tissue outside the uterine cavity. Its predominant symptom is pain, a condition notably altering the quality of life of women with the disease. This review is intended to exhaustively gather current knowledge on purinergic signaling in endometriosis-associated pain. Altered extracellular ATP hydrolysis, due to changes in ectonucleotidase activity, has been reported in endometriosis; the resulting accumulation of ATP in the endometriotic microenvironment points to sustained activation of nucleotide receptors (P2 receptors) capable of generating a persistent pain message. P2X3 receptor, expressed in sensory neurons, mediates nociceptive, neuropathic, and inflammatory pain, and is enrolled in endometriosis-related pain. Pharmacological inhibition of P2X3 receptor is under evaluation as a pain relief treatment for women with endometriosis. The role of other ATP receptors is also discussed here, e.g., P2X4 and P2X7 receptors, which are involved in inflammatory cell-nerve and microglia-nerve crosstalk, and therefore in inflammatory and neuropathic pain. Adenosine receptors (P1 receptors), by contrast, mainly play antinociceptive and anti-inflammatory roles. Purinome-targeted drugs, including nucleotide receptors and metabolizing enzymes, are potential non-hormonal therapeutic tools for the pharmacological management of endometriosis-related pain.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/183725Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/ijms21228512International Journal of Molecular Sciences, 2020, vol. 21, num. 22, p. 8512https://doi.org/10.3390/ijms21228512cc-by (c) Trapero, Carla et al., 2020https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1837252026-05-27T06:46:51Z
dc.title.none.fl_str_mv Purinergic signaling in endometriosis-associated pain
title Purinergic signaling in endometriosis-associated pain
spellingShingle Purinergic signaling in endometriosis-associated pain
Trapero, Carla
Endometriosi
Adenosina
Dolor
Inflamació
Endometriosis
Adenosine
Pain
Inflammation
title_short Purinergic signaling in endometriosis-associated pain
title_full Purinergic signaling in endometriosis-associated pain
title_fullStr Purinergic signaling in endometriosis-associated pain
title_full_unstemmed Purinergic signaling in endometriosis-associated pain
title_sort Purinergic signaling in endometriosis-associated pain
dc.creator.none.fl_str_mv Trapero, Carla
Martín Satué, Mireia
author Trapero, Carla
author_facet Trapero, Carla
Martín Satué, Mireia
author_role author
author2 Martín Satué, Mireia
author2_role author
dc.subject.none.fl_str_mv Endometriosi
Adenosina
Dolor
Inflamació
Endometriosis
Adenosine
Pain
Inflammation
topic Endometriosi
Adenosina
Dolor
Inflamació
Endometriosis
Adenosine
Pain
Inflammation
description Endometriosis is an estrogen-dependent gynecological disease, with an associated chronic inflammatory component, characterized by the presence of endometrial tissue outside the uterine cavity. Its predominant symptom is pain, a condition notably altering the quality of life of women with the disease. This review is intended to exhaustively gather current knowledge on purinergic signaling in endometriosis-associated pain. Altered extracellular ATP hydrolysis, due to changes in ectonucleotidase activity, has been reported in endometriosis; the resulting accumulation of ATP in the endometriotic microenvironment points to sustained activation of nucleotide receptors (P2 receptors) capable of generating a persistent pain message. P2X3 receptor, expressed in sensory neurons, mediates nociceptive, neuropathic, and inflammatory pain, and is enrolled in endometriosis-related pain. Pharmacological inhibition of P2X3 receptor is under evaluation as a pain relief treatment for women with endometriosis. The role of other ATP receptors is also discussed here, e.g., P2X4 and P2X7 receptors, which are involved in inflammatory cell-nerve and microglia-nerve crosstalk, and therefore in inflammatory and neuropathic pain. Adenosine receptors (P1 receptors), by contrast, mainly play antinociceptive and anti-inflammatory roles. Purinome-targeted drugs, including nucleotide receptors and metabolizing enzymes, are potential non-hormonal therapeutic tools for the pharmacological management of endometriosis-related pain.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/183725
url https://hdl.handle.net/2445/183725
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms21228512
International Journal of Molecular Sciences, 2020, vol. 21, num. 22, p. 8512
https://doi.org/10.3390/ijms21228512
dc.rights.none.fl_str_mv cc-by (c) Trapero, Carla et al., 2020
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Trapero, Carla et al., 2020
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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