Impaired HDL (High-Density Lipoprotein)-Mediated Macrophage Cholesterol Efflux in Patients With Abdominal Aortic Aneurysm-Brief Report

Objective The ability of HDL (high-density lipoprotein) to promote macrophage cholesterol efflux is considered the main HDL cardioprotective function. Abdominal aortic aneurysm (AAA) is usually characterized by cholesterol accumulation and macrophage infiltration in the aortic wall. Here, we aim to...

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Authors: Martinez-Lopez, D, Cedo, L, Metso, J, Burillo, E, Garcia-Leon, A, Canyelles, M, Lindholt, JS, Torres-Fonseca, M, Blanco-Colio, LM, Vazquez, J, Blanco-Vaca, F, Jauhiainen, M, Martin-Ventura, JL, Escola-Gil, JC
Format: article
Status:Published version
Publication Date:2018
Country:España
Institution:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repository:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p3715
Online Access:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3715
Access Level:Open access
Keyword:aneurysm
apolipoprotein
cells
cholesterol
macrophages
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spelling Impaired HDL (High-Density Lipoprotein)-Mediated Macrophage Cholesterol Efflux in Patients With Abdominal Aortic Aneurysm-Brief ReportMartinez-Lopez, DCedo, LMetso, JBurillo, EGarcia-Leon, ACanyelles, MLindholt, JSTorres-Fonseca, MBlanco-Colio, LMVazquez, JBlanco-Vaca, FJauhiainen, MMartin-Ventura, JLEscola-Gil, JCaneurysmapolipoproteincellscholesterolmacrophagesObjective The ability of HDL (high-density lipoprotein) to promote macrophage cholesterol efflux is considered the main HDL cardioprotective function. Abdominal aortic aneurysm (AAA) is usually characterized by cholesterol accumulation and macrophage infiltration in the aortic wall. Here, we aim to evaluate the composition of circulating HDL particles and their potential for promoting macrophage cholesterol efflux in AAA subjects. Approach and Results First, we randomly selected AAA and control subjects from Spain. The AAA patients in the Spanish cohort showed lower plasma apoA-I levels concomitantly associated with low levels of plasma HDL cholesterol and the amount of pre-HDL particles. We determined macrophage cholesterol efflux to apoB-depleted plasma, which contains mature HDL, pre-HDL particles and HDL regulatory proteins. ApoB-depleted plasma from AAA patients displayed an impaired ability to promote macrophage cholesterol efflux. Next, we replicated the experiments with AAA and control subjects derived from Danish cohort. Danish AAA patients also showed lower apoA-I levels and a defective HDL-mediated macrophage cholesterol efflux. Conclusions AAA patients show impaired HDL-facilitated cholesterol removal from macrophages, which could be mechanistically linked to AAA.LIPPINCOTT WILLIAMS & WILKINS2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3715ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGYISSN: 10795642ISSNe: 15244636reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p37152026-06-14T12:41:47Z
dc.title.none.fl_str_mv Impaired HDL (High-Density Lipoprotein)-Mediated Macrophage Cholesterol Efflux in Patients With Abdominal Aortic Aneurysm-Brief Report
title Impaired HDL (High-Density Lipoprotein)-Mediated Macrophage Cholesterol Efflux in Patients With Abdominal Aortic Aneurysm-Brief Report
spellingShingle Impaired HDL (High-Density Lipoprotein)-Mediated Macrophage Cholesterol Efflux in Patients With Abdominal Aortic Aneurysm-Brief Report
Martinez-Lopez, D
aneurysm
apolipoprotein
cells
cholesterol
macrophages
title_short Impaired HDL (High-Density Lipoprotein)-Mediated Macrophage Cholesterol Efflux in Patients With Abdominal Aortic Aneurysm-Brief Report
title_full Impaired HDL (High-Density Lipoprotein)-Mediated Macrophage Cholesterol Efflux in Patients With Abdominal Aortic Aneurysm-Brief Report
title_fullStr Impaired HDL (High-Density Lipoprotein)-Mediated Macrophage Cholesterol Efflux in Patients With Abdominal Aortic Aneurysm-Brief Report
title_full_unstemmed Impaired HDL (High-Density Lipoprotein)-Mediated Macrophage Cholesterol Efflux in Patients With Abdominal Aortic Aneurysm-Brief Report
title_sort Impaired HDL (High-Density Lipoprotein)-Mediated Macrophage Cholesterol Efflux in Patients With Abdominal Aortic Aneurysm-Brief Report
dc.creator.none.fl_str_mv Martinez-Lopez, D
Cedo, L
Metso, J
Burillo, E
Garcia-Leon, A
Canyelles, M
Lindholt, JS
Torres-Fonseca, M
Blanco-Colio, LM
Vazquez, J
Blanco-Vaca, F
Jauhiainen, M
Martin-Ventura, JL
Escola-Gil, JC
author Martinez-Lopez, D
author_facet Martinez-Lopez, D
Cedo, L
Metso, J
Burillo, E
Garcia-Leon, A
Canyelles, M
Lindholt, JS
Torres-Fonseca, M
Blanco-Colio, LM
Vazquez, J
Blanco-Vaca, F
Jauhiainen, M
Martin-Ventura, JL
Escola-Gil, JC
author_role author
author2 Cedo, L
Metso, J
Burillo, E
Garcia-Leon, A
Canyelles, M
Lindholt, JS
Torres-Fonseca, M
Blanco-Colio, LM
Vazquez, J
Blanco-Vaca, F
Jauhiainen, M
Martin-Ventura, JL
Escola-Gil, JC
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv aneurysm
apolipoprotein
cells
cholesterol
macrophages
topic aneurysm
apolipoprotein
cells
cholesterol
macrophages
description Objective The ability of HDL (high-density lipoprotein) to promote macrophage cholesterol efflux is considered the main HDL cardioprotective function. Abdominal aortic aneurysm (AAA) is usually characterized by cholesterol accumulation and macrophage infiltration in the aortic wall. Here, we aim to evaluate the composition of circulating HDL particles and their potential for promoting macrophage cholesterol efflux in AAA subjects. Approach and Results First, we randomly selected AAA and control subjects from Spain. The AAA patients in the Spanish cohort showed lower plasma apoA-I levels concomitantly associated with low levels of plasma HDL cholesterol and the amount of pre-HDL particles. We determined macrophage cholesterol efflux to apoB-depleted plasma, which contains mature HDL, pre-HDL particles and HDL regulatory proteins. ApoB-depleted plasma from AAA patients displayed an impaired ability to promote macrophage cholesterol efflux. Next, we replicated the experiments with AAA and control subjects derived from Danish cohort. Danish AAA patients also showed lower apoA-I levels and a defective HDL-mediated macrophage cholesterol efflux. Conclusions AAA patients show impaired HDL-facilitated cholesterol removal from macrophages, which could be mechanistically linked to AAA.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3715
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3715
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv LIPPINCOTT WILLIAMS & WILKINS
publisher.none.fl_str_mv LIPPINCOTT WILLIAMS & WILKINS
dc.source.none.fl_str_mv ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
ISSN: 10795642
ISSNe: 15244636
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869414541146718208
score 15,811543

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