Small renal masses in Latin-American population: characteristics and prognostic factors for survival, recurrence and metastasis - a multi-institutional study from LARCG database
Background To evaluate demographic, clinical and pathological characteristics of small renal masses (SRM) (<= 4 cm) in a Latin-American population provided by LARCG (Latin-American Renal Cancer Group) and analyze predictors of survival, recurrence and metastasis. Methods A multi-institutional ret...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Recursos: | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| Repositorio: | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| OAI Identifier: | oai:iibsantpau.fundanetsuite.com:p1789 |
| Acesso em linha: | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1789 |
| Access Level: | acceso abierto |
| Palavra-chave: | Kidney cancer Nephron-sparing surgery Latin America Renal cell carcinoma Nephrectomy |
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Small renal masses in Latin-American population: characteristics and prognostic factors for survival, recurrence and metastasis - a multi-institutional study from LARCG databaseMourao, TCAbreu, DCarvalhal, GFGueglio, Gda Costa, WHCalsavara, VFMeza-Montoya, LBengio, RGScorticati, CCastillejos-Molina, RRodriguez-Covarrubias, FAutran-Gomez, AMCampos-Salcedo, JGNolazco, AAmeri, CZampolli, HLangenhin, RMuguruza, DMachado, MTMingote, PClavijo, JNogueira, LClark, ORovegno, ARSecin, FPDecia, RGuimaraes, GCGlina, SRodriguez-Faba, OPalou, JZequi, SCKidney cancerNephron-sparing surgeryLatin AmericaRenal cell carcinomaNephrectomyBackground To evaluate demographic, clinical and pathological characteristics of small renal masses (SRM) (<= 4 cm) in a Latin-American population provided by LARCG (Latin-American Renal Cancer Group) and analyze predictors of survival, recurrence and metastasis. Methods A multi-institutional retrospective cohort study of 1523 patients submitted to surgical treatment for non-metastatic SRM from 1979 to 2016. Comparisons between radical (RN) or partial nephrectomy (PN) and young or elderly patients were performed. Kaplan-Meier curves and log-rank tests estimated 10-year overall survival. Predictors of local recurrence or metastasis were analyzed by a multivariable logistic regression model. Results PN and RN were performed in 897 (66%) and 461 (34%) patients. A proportional increase of PN cases from 48.5% (1979-2009) to 75% (after 2009) was evidenced. Stratifying by age, elderly patients (>= 65 years) had better 10-year OS rates when submitted to PN (83.5%), than RN (54.5%),p = 0.044. This disparity was not evidenced in younger patients. On multivariable model, bilaterality, extracapsular extension and ASA (American Society of Anesthesiologists) classification >= 3 were predictors of local recurrence. We did not identify significant predictors for distant metastasis in our series. Conclusions PN is performed in Latin-America in a similar proportion to developed areas and it has been increasing in the last years. Even in elderly individuals, if good functional status, sufficiently fit to surgery, and favorable tumor characteristics, they should be encouraged to perform PN. Intending to an earlier diagnosis of recurrence or distant metastasis, SRM cases with unfavorable characteristics should have a more rigorous follow-up routine.BMC2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1789BMC UrologyISSN: 14712490reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p17892026-06-14T12:41:47Z |
| dc.title.none.fl_str_mv |
Small renal masses in Latin-American population: characteristics and prognostic factors for survival, recurrence and metastasis - a multi-institutional study from LARCG database |
| title |
Small renal masses in Latin-American population: characteristics and prognostic factors for survival, recurrence and metastasis - a multi-institutional study from LARCG database |
| spellingShingle |
Small renal masses in Latin-American population: characteristics and prognostic factors for survival, recurrence and metastasis - a multi-institutional study from LARCG database Mourao, TC Kidney cancer Nephron-sparing surgery Latin America Renal cell carcinoma Nephrectomy |
| title_short |
Small renal masses in Latin-American population: characteristics and prognostic factors for survival, recurrence and metastasis - a multi-institutional study from LARCG database |
| title_full |
Small renal masses in Latin-American population: characteristics and prognostic factors for survival, recurrence and metastasis - a multi-institutional study from LARCG database |
| title_fullStr |
Small renal masses in Latin-American population: characteristics and prognostic factors for survival, recurrence and metastasis - a multi-institutional study from LARCG database |
| title_full_unstemmed |
Small renal masses in Latin-American population: characteristics and prognostic factors for survival, recurrence and metastasis - a multi-institutional study from LARCG database |
| title_sort |
Small renal masses in Latin-American population: characteristics and prognostic factors for survival, recurrence and metastasis - a multi-institutional study from LARCG database |
| dc.creator.none.fl_str_mv |
Mourao, TC Abreu, D Carvalhal, GF Gueglio, G da Costa, WH Calsavara, VF Meza-Montoya, L Bengio, RG Scorticati, C Castillejos-Molina, R Rodriguez-Covarrubias, F Autran-Gomez, AM Campos-Salcedo, JG Nolazco, A Ameri, C Zampolli, H Langenhin, R Muguruza, D Machado, MT Mingote, P Clavijo, J Nogueira, L Clark, O Rovegno, AR Secin, FP Decia, R Guimaraes, GC Glina, S Rodriguez-Faba, O Palou, J Zequi, SC |
| author |
Mourao, TC |
| author_facet |
Mourao, TC Abreu, D Carvalhal, GF Gueglio, G da Costa, WH Calsavara, VF Meza-Montoya, L Bengio, RG Scorticati, C Castillejos-Molina, R Rodriguez-Covarrubias, F Autran-Gomez, AM Campos-Salcedo, JG Nolazco, A Ameri, C Zampolli, H Langenhin, R Muguruza, D Machado, MT Mingote, P Clavijo, J Nogueira, L Clark, O Rovegno, AR Secin, FP Decia, R Guimaraes, GC Glina, S Rodriguez-Faba, O Palou, J Zequi, SC |
| author_role |
author |
| author2 |
Abreu, D Carvalhal, GF Gueglio, G da Costa, WH Calsavara, VF Meza-Montoya, L Bengio, RG Scorticati, C Castillejos-Molina, R Rodriguez-Covarrubias, F Autran-Gomez, AM Campos-Salcedo, JG Nolazco, A Ameri, C Zampolli, H Langenhin, R Muguruza, D Machado, MT Mingote, P Clavijo, J Nogueira, L Clark, O Rovegno, AR Secin, FP Decia, R Guimaraes, GC Glina, S Rodriguez-Faba, O Palou, J Zequi, SC |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Kidney cancer Nephron-sparing surgery Latin America Renal cell carcinoma Nephrectomy |
| topic |
Kidney cancer Nephron-sparing surgery Latin America Renal cell carcinoma Nephrectomy |
| description |
Background To evaluate demographic, clinical and pathological characteristics of small renal masses (SRM) (<= 4 cm) in a Latin-American population provided by LARCG (Latin-American Renal Cancer Group) and analyze predictors of survival, recurrence and metastasis. Methods A multi-institutional retrospective cohort study of 1523 patients submitted to surgical treatment for non-metastatic SRM from 1979 to 2016. Comparisons between radical (RN) or partial nephrectomy (PN) and young or elderly patients were performed. Kaplan-Meier curves and log-rank tests estimated 10-year overall survival. Predictors of local recurrence or metastasis were analyzed by a multivariable logistic regression model. Results PN and RN were performed in 897 (66%) and 461 (34%) patients. A proportional increase of PN cases from 48.5% (1979-2009) to 75% (after 2009) was evidenced. Stratifying by age, elderly patients (>= 65 years) had better 10-year OS rates when submitted to PN (83.5%), than RN (54.5%),p = 0.044. This disparity was not evidenced in younger patients. On multivariable model, bilaterality, extracapsular extension and ASA (American Society of Anesthesiologists) classification >= 3 were predictors of local recurrence. We did not identify significant predictors for distant metastasis in our series. Conclusions PN is performed in Latin-America in a similar proportion to developed areas and it has been increasing in the last years. Even in elderly individuals, if good functional status, sufficiently fit to surgery, and favorable tumor characteristics, they should be encouraged to perform PN. Intending to an earlier diagnosis of recurrence or distant metastasis, SRM cases with unfavorable characteristics should have a more rigorous follow-up routine. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1789 |
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https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1789 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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BMC |
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BMC |
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BMC Urology ISSN: 14712490 reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
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Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
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r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
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r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
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