Planarian Cell Number Depends on blitzschnell, a Novel Gene Family That Balances Cell Proliferation and Cell Death

Control of cell number is crucial to define body size during animal development and to restrict tumoral transformation. The cell number is determined by the balance between cell proliferation and cell death. Although many genes are known to regulate those processes, the molecular mechanisms underlyi...

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Autores: Pascual Carreras, Eudald, Marin Barba, Marta, Herrera Úbeda, Carlos, Font Martín, Daniel, Eckelt, Kay, Sousa, Nidia De, Garcia Fernández, Jordi, Saló i Boix, Emili, Adell i Creixell, Teresa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/170073
Acceso en línea:https://hdl.handle.net/2445/170073
Access Level:acceso abierto
Palabra clave:Proliferació cel·lular
Mort cel·lular
Regeneració (Biologia)
Cell proliferation
Cell death
Regeneration (Biology)
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spelling Planarian Cell Number Depends on blitzschnell, a Novel Gene Family That Balances Cell Proliferation and Cell DeathPascual Carreras, EudaldMarin Barba, MartaHerrera Úbeda, CarlosFont Martín, DanielEckelt, KaySousa, Nidia DeGarcia Fernández, JordiSaló i Boix, EmiliAdell i Creixell, TeresaProliferació cel·lularMort cel·lularRegeneració (Biologia)Cell proliferationCell deathRegeneration (Biology)Control of cell number is crucial to define body size during animal development and to restrict tumoral transformation. The cell number is determined by the balance between cell proliferation and cell death. Although many genes are known to regulate those processes, the molecular mechanisms underlying the relationship between cell number and body size remain poorly understood. This relationship can be better understood by studying planarians, flatworms that continuously change their body size according to nutrient availability. We identified a novel gene family, blitzschnell (bls), that consists of de novo and taxonomically restricted genes that control cell proliferation:cell death ratio. Their silencing promotes faster regeneration and increases cell number during homeostasis. Importantly, this increase in cell number leads to an increase in body size only in a nutrient-rich environment; in starved planarians, silencing results in a decrease in cell size and cell accumulation that ultimately produces overgrowths. bls expression is downregulated after feeding and is related to activity of the insulin/Akt/mTOR network, suggesting that the bls family evolved in planarians as an additional mechanism for restricting cell number in nutrient-fluctuating environments.The Company of Biologists2020202120202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/170073Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1242/dev.184044Development, 2020, vol. 147, num. 7, p. 184044https://doi.org/10.1242/dev.184044(c) Pascual Carreras, Eudald et al., 2020info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1700732026-05-29T05:05:01Z
dc.title.none.fl_str_mv Planarian Cell Number Depends on blitzschnell, a Novel Gene Family That Balances Cell Proliferation and Cell Death
title Planarian Cell Number Depends on blitzschnell, a Novel Gene Family That Balances Cell Proliferation and Cell Death
spellingShingle Planarian Cell Number Depends on blitzschnell, a Novel Gene Family That Balances Cell Proliferation and Cell Death
Pascual Carreras, Eudald
Proliferació cel·lular
Mort cel·lular
Regeneració (Biologia)
Cell proliferation
Cell death
Regeneration (Biology)
title_short Planarian Cell Number Depends on blitzschnell, a Novel Gene Family That Balances Cell Proliferation and Cell Death
title_full Planarian Cell Number Depends on blitzschnell, a Novel Gene Family That Balances Cell Proliferation and Cell Death
title_fullStr Planarian Cell Number Depends on blitzschnell, a Novel Gene Family That Balances Cell Proliferation and Cell Death
title_full_unstemmed Planarian Cell Number Depends on blitzschnell, a Novel Gene Family That Balances Cell Proliferation and Cell Death
title_sort Planarian Cell Number Depends on blitzschnell, a Novel Gene Family That Balances Cell Proliferation and Cell Death
dc.creator.none.fl_str_mv Pascual Carreras, Eudald
Marin Barba, Marta
Herrera Úbeda, Carlos
Font Martín, Daniel
Eckelt, Kay
Sousa, Nidia De
Garcia Fernández, Jordi
Saló i Boix, Emili
Adell i Creixell, Teresa
author Pascual Carreras, Eudald
author_facet Pascual Carreras, Eudald
Marin Barba, Marta
Herrera Úbeda, Carlos
Font Martín, Daniel
Eckelt, Kay
Sousa, Nidia De
Garcia Fernández, Jordi
Saló i Boix, Emili
Adell i Creixell, Teresa
author_role author
author2 Marin Barba, Marta
Herrera Úbeda, Carlos
Font Martín, Daniel
Eckelt, Kay
Sousa, Nidia De
Garcia Fernández, Jordi
Saló i Boix, Emili
Adell i Creixell, Teresa
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Proliferació cel·lular
Mort cel·lular
Regeneració (Biologia)
Cell proliferation
Cell death
Regeneration (Biology)
topic Proliferació cel·lular
Mort cel·lular
Regeneració (Biologia)
Cell proliferation
Cell death
Regeneration (Biology)
description Control of cell number is crucial to define body size during animal development and to restrict tumoral transformation. The cell number is determined by the balance between cell proliferation and cell death. Although many genes are known to regulate those processes, the molecular mechanisms underlying the relationship between cell number and body size remain poorly understood. This relationship can be better understood by studying planarians, flatworms that continuously change their body size according to nutrient availability. We identified a novel gene family, blitzschnell (bls), that consists of de novo and taxonomically restricted genes that control cell proliferation:cell death ratio. Their silencing promotes faster regeneration and increases cell number during homeostasis. Importantly, this increase in cell number leads to an increase in body size only in a nutrient-rich environment; in starved planarians, silencing results in a decrease in cell size and cell accumulation that ultimately produces overgrowths. bls expression is downregulated after feeding and is related to activity of the insulin/Akt/mTOR network, suggesting that the bls family evolved in planarians as an additional mechanism for restricting cell number in nutrient-fluctuating environments.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/170073
url https://hdl.handle.net/2445/170073
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1242/dev.184044
Development, 2020, vol. 147, num. 7, p. 184044
https://doi.org/10.1242/dev.184044
dc.rights.none.fl_str_mv (c) Pascual Carreras, Eudald et al., 2020
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Pascual Carreras, Eudald et al., 2020
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv The Company of Biologists
publisher.none.fl_str_mv The Company of Biologists
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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