Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status

Aims: To evaluate the effect of iron deficiency (ID) and/or anaemia on health-related quality of life (HRQoL) in patients with chronic heart failure (CHF). Methods and results: We undertook a post-hoc analysis of a cohort of CHF patients in a single-centre study evaluating cognitive function. At rec...

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Autores: Comín Colet, Josep, Enjuanes Grau, Cristina, González, Gina, Torrens, Ainhoa, Cladellas, Mercè, Meroño, Oona, Ribas Barquet, Núria, Ruiz, Sonia, Gómez, Miquel, Verdú-Rotellar, José María, Bruguera-Cortada, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/69247
Acceso en línea:http://hdl.handle.net/10230/69247
http://dx.doi.org/10.1093/eurjhf/hft083
Access Level:acceso abierto
Palabra clave:Anaemia
Health-related quality of life
Iron deficiency
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spelling Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia statusComín Colet, JosepEnjuanes Grau, CristinaGonzález, GinaTorrens, AinhoaCladellas, MercèMeroño, OonaRibas Barquet, NúriaRuiz, SoniaGómez, MiquelVerdú-Rotellar, José MaríaBruguera-Cortada, JordiAnaemiaHealth-related quality of lifeIron deficiencyAims: To evaluate the effect of iron deficiency (ID) and/or anaemia on health-related quality of life (HRQoL) in patients with chronic heart failure (CHF). Methods and results: We undertook a post-hoc analysis of a cohort of CHF patients in a single-centre study evaluating cognitive function. At recruitment, patients provided baseline information and completed the Minnesota Living with Heart Failure questionnaire (MLHFQ) for HRQoL (higher scores reflect worse HRQoL). At the same time, blood samples were taken for serological evaluation. ID was defined as serum ferritin levels <100 ng/mL or serum ferritin <800 ng/mL with transferrin saturation <20%. Anaemia was defined as haemoglobin ≤12 g/dL. A total of 552 CHF patients were eligible for inclusion, with an average age of 72 years and 40% in NYHA class III or IV. The MLHFQ overall summary scores were 41.0 ± 24.7 among those with ID, vs. 34.4 ± 26.4 for non-ID patients (P = 0.003), indicating worse HRQoL. When adjusted for other factors associated with HRQoL, ID was significantly associated with worse MLHFQ overall summary (P = 0.008) and physical dimension scores (P = 0.002), whereas anaemia was not (both P > 0.05). Increased levels of soluble transferrin receptor were also associated with impaired HRQoL (P ≤ 0.001). Adjusting for haemoglobin and C-reactive protein, ID was more pronounced in patients with anaemia compared with those without (P < 0.001). Conclusion: In patients with CHF, ID but not anaemia was associated with reduced HRQoL, mostly due to physical factors.Wiley202520252013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/69247http://dx.doi.org/10.1093/eurjhf/hft083reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésEur J Heart Fail. 2013 Oct;15(10):1164-72© The Author 2013. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.http://creativecommons.org/licenses/by-nc/3.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/692472026-06-12T07:21:37Z
dc.title.none.fl_str_mv Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status
title Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status
spellingShingle Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status
Comín Colet, Josep
Anaemia
Health-related quality of life
Iron deficiency
title_short Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status
title_full Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status
title_fullStr Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status
title_full_unstemmed Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status
title_sort Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status
dc.creator.none.fl_str_mv Comín Colet, Josep
Enjuanes Grau, Cristina
González, Gina
Torrens, Ainhoa
Cladellas, Mercè
Meroño, Oona
Ribas Barquet, Núria
Ruiz, Sonia
Gómez, Miquel
Verdú-Rotellar, José María
Bruguera-Cortada, Jordi
author Comín Colet, Josep
author_facet Comín Colet, Josep
Enjuanes Grau, Cristina
González, Gina
Torrens, Ainhoa
Cladellas, Mercè
Meroño, Oona
Ribas Barquet, Núria
Ruiz, Sonia
Gómez, Miquel
Verdú-Rotellar, José María
Bruguera-Cortada, Jordi
author_role author
author2 Enjuanes Grau, Cristina
González, Gina
Torrens, Ainhoa
Cladellas, Mercè
Meroño, Oona
Ribas Barquet, Núria
Ruiz, Sonia
Gómez, Miquel
Verdú-Rotellar, José María
Bruguera-Cortada, Jordi
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anaemia
Health-related quality of life
Iron deficiency
topic Anaemia
Health-related quality of life
Iron deficiency
description Aims: To evaluate the effect of iron deficiency (ID) and/or anaemia on health-related quality of life (HRQoL) in patients with chronic heart failure (CHF). Methods and results: We undertook a post-hoc analysis of a cohort of CHF patients in a single-centre study evaluating cognitive function. At recruitment, patients provided baseline information and completed the Minnesota Living with Heart Failure questionnaire (MLHFQ) for HRQoL (higher scores reflect worse HRQoL). At the same time, blood samples were taken for serological evaluation. ID was defined as serum ferritin levels <100 ng/mL or serum ferritin <800 ng/mL with transferrin saturation <20%. Anaemia was defined as haemoglobin ≤12 g/dL. A total of 552 CHF patients were eligible for inclusion, with an average age of 72 years and 40% in NYHA class III or IV. The MLHFQ overall summary scores were 41.0 ± 24.7 among those with ID, vs. 34.4 ± 26.4 for non-ID patients (P = 0.003), indicating worse HRQoL. When adjusted for other factors associated with HRQoL, ID was significantly associated with worse MLHFQ overall summary (P = 0.008) and physical dimension scores (P = 0.002), whereas anaemia was not (both P > 0.05). Increased levels of soluble transferrin receptor were also associated with impaired HRQoL (P ≤ 0.001). Adjusting for haemoglobin and C-reactive protein, ID was more pronounced in patients with anaemia compared with those without (P < 0.001). Conclusion: In patients with CHF, ID but not anaemia was associated with reduced HRQoL, mostly due to physical factors.
publishDate 2013
dc.date.none.fl_str_mv 2013
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/69247
http://dx.doi.org/10.1093/eurjhf/hft083
url http://hdl.handle.net/10230/69247
http://dx.doi.org/10.1093/eurjhf/hft083
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Eur J Heart Fail. 2013 Oct;15(10):1164-72
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc/3.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/3.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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