Nucleosome Dynamics: A new tool for the dynamic analysis of nucleosome positioning

We present Nucleosome Dynamics, a suite of programs integrated into a virtual research environment and created to define nucleosome architecture and dynamics from noisy experimental data. The package allows both the definition of nucleosome architectures and the detection of changes in nucleosomal o...

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Detalles Bibliográficos
Autores: Buitrago Ospina, Diana Camila, Codó Tarraubella, Laia, Illa Pujagut, Ricard, Jorge, Pau de, Flores Guri, Oscar, Battistini, Federica, Bayarri, Genís, Royo, Romina, Del Pino, Marc, Heath, Simon C., Hospital, Adam, Gelpí Buchaca, Josep Lluís, Brun Heath, Isabelle, Orozco López, Modesto
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/151347
Acceso en línea:https://hdl.handle.net/2445/151347
Access Level:acceso abierto
Palabra clave:Cromatina
Bioinformàtica
Chromatin
Bioinformatics
Descripción
Sumario:We present Nucleosome Dynamics, a suite of programs integrated into a virtual research environment and created to define nucleosome architecture and dynamics from noisy experimental data. The package allows both the definition of nucleosome architectures and the detection of changes in nucleosomal organization due to changes in cellular conditions. Results are displayed in the context of genomic information thanks to different visualizers and browsers, allowing the user a holistic, multidimensional view of the genome/transcriptome. The package shows good performance for both locating equilibrium nucleosome architecture and nucleosome dynamics and provides abundant useful information in several test cases, where experimental data on nucleosome position (and for some cases expression level) have been collected for cells under different external conditions (cell cycle phase, yeast metabolic cycle progression, changes in nutrients or difference in MNase digestion level). Nucleosome Dynamics is a free software and is provided under several distribution models.

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