Moderate-high blood eosinophilia is associated with increased hospitalization and other asthma comorbidities

(1) Background: Eosinophilia has traditionally been linked to eosinophilic asthma, for which it is the gold-standard prognostic biomarker. However, the association between eosinophilia and the presence of other diseases and comorbidities is yet unclear. (2) Methods: For this retrospective study, we...

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Detalles Bibliográficos
Autores: Naharro González, Sara, Lorente Sorolla, Clara, Rodrigo Muñoz, José Manuel, Valverde Monge, Marcela, Pinillos Robles, Erwin Javier, Betancor, Diana, Fernández Nieto, Mar, Sánchez Mellado, Diana, Gil Martinez, Marta, Santillán Coello, Jessica Mireya, Villacampa Aubá, José Miguel, Mahíllo Fernández, Ignacio, Herrero González, Antonio, Pérez González, Alejandro, Rodríguez Nieto, María Jesús, Pozo Abejón, María Victoria del
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/720066
Acceso en línea:http://hdl.handle.net/10486/720066
https://dx.doi.org/10.3390/biom14010126
Access Level:acceso abierto
Palabra clave:asthma
biomarker
blood eosinophils
COPD
CRSwNP
diagnosis
hospitalization
Medicina
Descripción
Sumario:(1) Background: Eosinophilia has traditionally been linked to eosinophilic asthma, for which it is the gold-standard prognostic biomarker. However, the association between eosinophilia and the presence of other diseases and comorbidities is yet unclear. (2) Methods: For this retrospective study, we reviewed the electronic medical records of 49,909 subjects with blood eosinophilia to gather data on the presence of asthma, COPD, sleep apnea, tuberculosis, dyslipidemia, hypertension, and other cardiovascular diseases and severe CRSwNP among these subjects. Demographic features including age, sex, and smoking habits were collected, as well as the number of hospitalizations and emergency department visits. T-tests, ANOVA, Fisher test, and logistic regression models were used. (3) Results: For all age groups studied, eosinophilia was significantly more prevalent among asthmatic subjects than nonasthmatics, especially in patients also presenting CRSwNP, hypertension, and dyslipidemia. The likelihood of developing asthma, COPD, and CRSwNP, and hospitalization, was increased when BEC was above 600 eosinophils/μL. The association between asthma, CRSwNP, and BEC was corroborated by multiple logistic regressions models. (4) Conclusions: We demonstrated the association of having over 600 blood eosinophils/μL with a higher number of hospitalizations and comorbidities (CRSwNP and COPD), which proves that BEC is a highly useful parameter to consider in subjects who present blood eosinophilia

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