MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy

Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia ( ALL). Methylenetetrahydrofolate reductase ( MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide polymorphisms in MTHFR gene, C677T and A1298C, affecting MTHFR activit...

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Detalhes bibliográficos
Autores: Umerez Igartua, Maitane, Gutiérrez Camino, Ángela, Muñoz Maldonado, Carmen, Martín Guerrero, Idoia, García-Orad Carles, África
Formato: artículo
Fecha de publicación:2017
País:España
Recursos:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/21505
Acesso em linha:http://hdl.handle.net/10810/21505
Access Level:acceso abierto
Palavra-chave:MTHFR
toxicity
outcome
C677T
A1298C
methylenetetrahidrofolate reductase C677T
genetic polymorphisms
candidate genes
risk-factors
children
pharmacogenetics
association
SLCO1B1
metaanalysis
MOLECULAR MEDICINE
PHARMACOLOGY AND PHARMACY
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network_acronym_str ES
network_name_str España
repository_id_str
spelling MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapyUmerez Igartua, MaitaneGutiérrez Camino, ÁngelaMuñoz Maldonado, CarmenMartín Guerrero, IdoiaGarcía-Orad Carles, ÁfricaMTHFRtoxicityoutcomeC677TA1298Cmethylenetetrahidrofolate reductase C677Tgenetic polymorphismscandidate genesrisk-factorschildrentoxicitypharmacogeneticsassociationSLCO1B1metaanalysisMOLECULAR MEDICINEPHARMACOLOGY AND PHARMACYMethotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia ( ALL). Methylenetetrahydrofolate reductase ( MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide polymorphisms in MTHFR gene, C677T and A1298C, affecting MTHFR activity, have been widely studied as potential markers of MTX toxicity and/or outcome in pediatric ALL. In this review, we show that the majority of published reports do not find association or present opposite effect. Therefore, MTHFR C677T and A1298C polymorphisms do not seem to be good markers of MTX-related toxicity and/or outcome in pediatric ALL. The efforts should be focused on other genes, such as transporter genes or microRNA-related genes.Dove Medical Press201720172017info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/21505reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.dovepress.com/mthfr-polymorphisms-in-childhood-acute-lymphoblastic-leukemia-influenc-peer-reviewed-article-PGPMinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/3.0/es/© 2017 Umerez et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.phpAtribución-NoComercial 3.0 Españaoai:addi.ehu.eus:10810/215052026-06-18T09:23:17Z
dc.title.none.fl_str_mv MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
title MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
spellingShingle MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
Umerez Igartua, Maitane
MTHFR
toxicity
outcome
C677T
A1298C
methylenetetrahidrofolate reductase C677T
genetic polymorphisms
candidate genes
risk-factors
children
toxicity
pharmacogenetics
association
SLCO1B1
metaanalysis
MOLECULAR MEDICINE
PHARMACOLOGY AND PHARMACY
title_short MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
title_full MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
title_fullStr MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
title_full_unstemmed MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
title_sort MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
dc.creator.none.fl_str_mv Umerez Igartua, Maitane
Gutiérrez Camino, Ángela
Muñoz Maldonado, Carmen
Martín Guerrero, Idoia
García-Orad Carles, África
author Umerez Igartua, Maitane
author_facet Umerez Igartua, Maitane
Gutiérrez Camino, Ángela
Muñoz Maldonado, Carmen
Martín Guerrero, Idoia
García-Orad Carles, África
author_role author
author2 Gutiérrez Camino, Ángela
Muñoz Maldonado, Carmen
Martín Guerrero, Idoia
García-Orad Carles, África
author2_role author
author
author
author
dc.subject.none.fl_str_mv MTHFR
toxicity
outcome
C677T
A1298C
methylenetetrahidrofolate reductase C677T
genetic polymorphisms
candidate genes
risk-factors
children
toxicity
pharmacogenetics
association
SLCO1B1
metaanalysis
MOLECULAR MEDICINE
PHARMACOLOGY AND PHARMACY
topic MTHFR
toxicity
outcome
C677T
A1298C
methylenetetrahidrofolate reductase C677T
genetic polymorphisms
candidate genes
risk-factors
children
toxicity
pharmacogenetics
association
SLCO1B1
metaanalysis
MOLECULAR MEDICINE
PHARMACOLOGY AND PHARMACY
description Methotrexate (MTX) is an important component in the therapy used to treat childhood acute lymphoblastic leukemia ( ALL). Methylenetetrahydrofolate reductase ( MTHFR) is a key enzyme for MTX pharmacokinetics. Two single-nucleotide polymorphisms in MTHFR gene, C677T and A1298C, affecting MTHFR activity, have been widely studied as potential markers of MTX toxicity and/or outcome in pediatric ALL. In this review, we show that the majority of published reports do not find association or present opposite effect. Therefore, MTHFR C677T and A1298C polymorphisms do not seem to be good markers of MTX-related toxicity and/or outcome in pediatric ALL. The efforts should be focused on other genes, such as transporter genes or microRNA-related genes.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/21505
url http://hdl.handle.net/10810/21505
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.dovepress.com/mthfr-polymorphisms-in-childhood-acute-lymphoblastic-leukemia-influenc-peer-reviewed-article-PGPM
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/3.0/es/
Atribución-NoComercial 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/3.0/es/
Atribución-NoComercial 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Dove Medical Press
publisher.none.fl_str_mv Dove Medical Press
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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