The epidemiology of invasive meningococcal disease in EU/EEA countries, 2004-2014

Background: Invasive meningococcal disease (IMD) is a major cause of bacterial meningitis and septicaemia although infection by some serogroups may be prevented through vaccination. We aimed to describe the epidemiology of IMD in EU/EEA countries during 2004-2014 to monitor serogroup- and age-specif...

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Authors: Whittaker, Robert, Dias, Joana Gomes, Ramliden, Miriam, Ködmön, Csaba, Economopoulou, Assimoula, Beer, Netta, Pastore Celentano, Lucia, ECDC network members for invasive meningococcal disease, Cano-Portero, Rosa, Abad, Raquel
Format: article
Publication Date:2017
Country:España
Institution:Instituto de Salud Carlos III (ISCIII)
Repository:Repisalud
Language:English
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/25509
Online Access:https://hdl.handle.net/20.500.12105/25509
Access Level:Open access
Keyword:Epidemiology
Europe
Invasive meningococcal disease (IMD)
Neisseria meningitidis
Serogroup
Surveillance
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Child
Child, Preschool
Female
Humans
Incidence
Infant
Male
Meningitis, Meningococcal
Meningococcal Vaccines
Middle Aged
Sepsis
Sex Distribution
Young Adult
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spelling The epidemiology of invasive meningococcal disease in EU/EEA countries, 2004-2014Whittaker, RobertDias, Joana GomesRamliden, MiriamKödmön, CsabaEconomopoulou, AssimoulaBeer, NettaPastore Celentano, LuciaECDC network members for invasive meningococcal diseaseCano-Portero, RosaAbad, RaquelEpidemiologyEuropeInvasive meningococcal disease (IMD)Neisseria meningitidisSerogroupSurveillanceAdolescentAdultAge DistributionAgedAged, 80 and overChildChild, PreschoolEuropeFemaleHumansIncidenceInfantMaleMeningitis, MeningococcalMeningococcal VaccinesMiddle AgedNeisseria meningitidisSepsisSerogroupSex DistributionYoung AdultBackground: Invasive meningococcal disease (IMD) is a major cause of bacterial meningitis and septicaemia although infection by some serogroups may be prevented through vaccination. We aimed to describe the epidemiology of IMD in EU/EEA countries during 2004-2014 to monitor serogroup- and age-specific trends, and compare country trends by the period of meningococcal C conjugate (MCC) vaccine introduction. Methods: We analysed IMD surveillance data by age, gender, serogroup, country and outcome. We estimated the percentage change in annual notification rate (NR), using linear regression analysis of the log of the annual NR. We grouped countries by the year they introduced MCC vaccination into their routine immunisation programmes. Results: The overall NR was 0.9/100 000 population, and decreased 6.6% (95%CI: -8.0%;-5.1%) annually. Infants had the highest NR (16.0/100 000), and there were decreasing trends in all age groups <50years. Serogroup B (SgB) caused 74% of all cases, and the majority of cases in all age groups. There were decreasing trends in SgB and serogroup C (SgC) and an increasing trend in serogroup Y. Countries that introduced MCC vaccination before, and between 2004 and 2014, had decreasing trends in NR of SgC, but not countries without routine MCC vaccination. Conclusions: Our findings support evidence that routine MCC vaccination was the driving force behind the decreasing SgC trend. Vaccinating against SgB in the first year of life could help reduce the burden of IMD due to this serogroup. Changing serogroup-specific NR trends highlight the need for high-quality surveillance data to accurately assess the changing epidemiology of IMD, the effectiveness and impact of implemented vaccines, and the need for future vaccines.Elsevier20242024-11-1420172017-04-1120172017-04-11research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12105/25509reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/255092026-06-12T12:43:37Z
dc.title.none.fl_str_mv The epidemiology of invasive meningococcal disease in EU/EEA countries, 2004-2014
title The epidemiology of invasive meningococcal disease in EU/EEA countries, 2004-2014
spellingShingle The epidemiology of invasive meningococcal disease in EU/EEA countries, 2004-2014
Whittaker, Robert
Epidemiology
Europe
Invasive meningococcal disease (IMD)
Neisseria meningitidis
Serogroup
Surveillance
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Child
Child, Preschool
Europe
Female
Humans
Incidence
Infant
Male
Meningitis, Meningococcal
Meningococcal Vaccines
Middle Aged
Neisseria meningitidis
Sepsis
Serogroup
Sex Distribution
Young Adult
title_short The epidemiology of invasive meningococcal disease in EU/EEA countries, 2004-2014
title_full The epidemiology of invasive meningococcal disease in EU/EEA countries, 2004-2014
title_fullStr The epidemiology of invasive meningococcal disease in EU/EEA countries, 2004-2014
title_full_unstemmed The epidemiology of invasive meningococcal disease in EU/EEA countries, 2004-2014
title_sort The epidemiology of invasive meningococcal disease in EU/EEA countries, 2004-2014
dc.creator.none.fl_str_mv Whittaker, Robert
Dias, Joana Gomes
Ramliden, Miriam
Ködmön, Csaba
Economopoulou, Assimoula
Beer, Netta
Pastore Celentano, Lucia
ECDC network members for invasive meningococcal disease
Cano-Portero, Rosa
Abad, Raquel
author Whittaker, Robert
author_facet Whittaker, Robert
Dias, Joana Gomes
Ramliden, Miriam
Ködmön, Csaba
Economopoulou, Assimoula
Beer, Netta
Pastore Celentano, Lucia
ECDC network members for invasive meningococcal disease
Cano-Portero, Rosa
Abad, Raquel
author_role author
author2 Dias, Joana Gomes
Ramliden, Miriam
Ködmön, Csaba
Economopoulou, Assimoula
Beer, Netta
Pastore Celentano, Lucia
ECDC network members for invasive meningococcal disease
Cano-Portero, Rosa
Abad, Raquel
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Epidemiology
Europe
Invasive meningococcal disease (IMD)
Neisseria meningitidis
Serogroup
Surveillance
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Child
Child, Preschool
Europe
Female
Humans
Incidence
Infant
Male
Meningitis, Meningococcal
Meningococcal Vaccines
Middle Aged
Neisseria meningitidis
Sepsis
Serogroup
Sex Distribution
Young Adult
topic Epidemiology
Europe
Invasive meningococcal disease (IMD)
Neisseria meningitidis
Serogroup
Surveillance
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Child
Child, Preschool
Europe
Female
Humans
Incidence
Infant
Male
Meningitis, Meningococcal
Meningococcal Vaccines
Middle Aged
Neisseria meningitidis
Sepsis
Serogroup
Sex Distribution
Young Adult
description Background: Invasive meningococcal disease (IMD) is a major cause of bacterial meningitis and septicaemia although infection by some serogroups may be prevented through vaccination. We aimed to describe the epidemiology of IMD in EU/EEA countries during 2004-2014 to monitor serogroup- and age-specific trends, and compare country trends by the period of meningococcal C conjugate (MCC) vaccine introduction. Methods: We analysed IMD surveillance data by age, gender, serogroup, country and outcome. We estimated the percentage change in annual notification rate (NR), using linear regression analysis of the log of the annual NR. We grouped countries by the year they introduced MCC vaccination into their routine immunisation programmes. Results: The overall NR was 0.9/100 000 population, and decreased 6.6% (95%CI: -8.0%;-5.1%) annually. Infants had the highest NR (16.0/100 000), and there were decreasing trends in all age groups <50years. Serogroup B (SgB) caused 74% of all cases, and the majority of cases in all age groups. There were decreasing trends in SgB and serogroup C (SgC) and an increasing trend in serogroup Y. Countries that introduced MCC vaccination before, and between 2004 and 2014, had decreasing trends in NR of SgC, but not countries without routine MCC vaccination. Conclusions: Our findings support evidence that routine MCC vaccination was the driving force behind the decreasing SgC trend. Vaccinating against SgB in the first year of life could help reduce the burden of IMD due to this serogroup. Changing serogroup-specific NR trends highlight the need for high-quality surveillance data to accurately assess the changing epidemiology of IMD, the effectiveness and impact of implemented vaccines, and the need for future vaccines.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-04-11
2017
2017-04-11
2024
2024-11-14
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/25509
url https://hdl.handle.net/20.500.12105/25509
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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