Tetraspanins as Organizers of Antigen-Presenting Cell Function

Professional antigen-presenting cells (APCs) include dendritic cells, monocytes, and B cells. APCs internalize and process antigens, producing immunogenic peptides that enable antigen presentation to T lymphocytes, which provide the signals that trigger T-cell activation, proliferation, and differen...

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Detalles Bibliográficos
Autores: Saiz, Maria Laura, Rocha-Perugini, Vera, Sanchez-Madrid, Francisco
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/6667
Acceso en línea:http://hdl.handle.net/20.500.12105/6667
Access Level:acceso abierto
Palabra clave:Tetraspanins
Tetraspanin-enriched microdomains
Antigen-presenting cells
Immune receptors
Cell migration
Antigen presentation
MHC CLASS-II
PLASMACYTOID DENDRITIC CELLS
HEPATITIS-C VIRUS
T-CELLS
MOLECULAR CHARACTERIZATION
MEMBRANE MICRODOMAIN
SIGNALING COMPLEXES
PEPTIDE COMPLEXES
DISTINCT SUBSET
DOWN-REGULATION
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spelling Tetraspanins as Organizers of Antigen-Presenting Cell FunctionSaiz, Maria LauraRocha-Perugini, VeraSanchez-Madrid, FranciscoTetraspaninsTetraspanin-enriched microdomainsAntigen-presenting cellsImmune receptorsCell migrationAntigen presentationMHC CLASS-IIPLASMACYTOID DENDRITIC CELLSHEPATITIS-C VIRUST-CELLSMOLECULAR CHARACTERIZATIONMEMBRANE MICRODOMAINSIGNALING COMPLEXESPEPTIDE COMPLEXESDISTINCT SUBSETDOWN-REGULATIONProfessional antigen-presenting cells (APCs) include dendritic cells, monocytes, and B cells. APCs internalize and process antigens, producing immunogenic peptides that enable antigen presentation to T lymphocytes, which provide the signals that trigger T-cell activation, proliferation, and differentiation, and lead to adaptive immune responses. After detection of microbial antigens through pattern recognition receptors (PRRs), APCs migrate to secondary lymphoid organs where antigen presentation to T lymphocytes takes place. Tetraspanins are membrane proteins that organize specialized membrane platforms, called tetraspanin-enriched microdomains, which integrate membrane receptors, like PRR and major histocompatibility complex class II (MHC-II), adhesion proteins, and signaling molecules. Importantly, through the modulation of the function of their associated membrane partners, tetraspanins regulate different steps of the immune response. Several tetraspanins can positively or negatively regulate the activation threshold of immune receptors. They also play a role during migration of APCs by controlling the surface levels and spatial arrangement of adhesion molecules and their subsequent intracellular signaling. Finally, tetraspanins participate in antigen processing and are important for priming of naive T cells through the control of T-cell co-stimulation and MHC-II-dependent antigen presentation. In this review, we discuss the role of tetraspanins in APC biology and their involvement in effective immune responses.Frontiers MediaEuropean Regional Development FundMinisterio de Economía, Innovación y Competitividad (España)Fundación ProCNICCentro de Investigación Biomedica en Red - CIBERUnión Europea. Comisión EuropeaUnión Europea. Comisión Europea. European Research Council (ERC)20182018-11-2220182018-01-0120182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/6667reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Seventh Framework Programme 294340ES SAF2014-54705-R Not availableES SAF2017-82886-R Not availableES B2017 BMD-3671-INFLAMUNEES PIE13 00041open accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/66672026-06-12T12:43:37Z
dc.title.none.fl_str_mv Tetraspanins as Organizers of Antigen-Presenting Cell Function
title Tetraspanins as Organizers of Antigen-Presenting Cell Function
spellingShingle Tetraspanins as Organizers of Antigen-Presenting Cell Function
Saiz, Maria Laura
Tetraspanins
Tetraspanin-enriched microdomains
Antigen-presenting cells
Immune receptors
Cell migration
Antigen presentation
MHC CLASS-II
PLASMACYTOID DENDRITIC CELLS
HEPATITIS-C VIRUS
T-CELLS
MOLECULAR CHARACTERIZATION
MEMBRANE MICRODOMAIN
SIGNALING COMPLEXES
PEPTIDE COMPLEXES
DISTINCT SUBSET
DOWN-REGULATION
title_short Tetraspanins as Organizers of Antigen-Presenting Cell Function
title_full Tetraspanins as Organizers of Antigen-Presenting Cell Function
title_fullStr Tetraspanins as Organizers of Antigen-Presenting Cell Function
title_full_unstemmed Tetraspanins as Organizers of Antigen-Presenting Cell Function
title_sort Tetraspanins as Organizers of Antigen-Presenting Cell Function
dc.creator.none.fl_str_mv Saiz, Maria Laura
Rocha-Perugini, Vera
Sanchez-Madrid, Francisco
author Saiz, Maria Laura
author_facet Saiz, Maria Laura
Rocha-Perugini, Vera
Sanchez-Madrid, Francisco
author_role author
author2 Rocha-Perugini, Vera
Sanchez-Madrid, Francisco
author2_role author
author
dc.contributor.none.fl_str_mv European Regional Development Fund
Ministerio de Economía, Innovación y Competitividad (España)
Fundación ProCNIC
Centro de Investigación Biomedica en Red - CIBER
Unión Europea. Comisión Europea
Unión Europea. Comisión Europea. European Research Council (ERC)
dc.subject.none.fl_str_mv Tetraspanins
Tetraspanin-enriched microdomains
Antigen-presenting cells
Immune receptors
Cell migration
Antigen presentation
MHC CLASS-II
PLASMACYTOID DENDRITIC CELLS
HEPATITIS-C VIRUS
T-CELLS
MOLECULAR CHARACTERIZATION
MEMBRANE MICRODOMAIN
SIGNALING COMPLEXES
PEPTIDE COMPLEXES
DISTINCT SUBSET
DOWN-REGULATION
topic Tetraspanins
Tetraspanin-enriched microdomains
Antigen-presenting cells
Immune receptors
Cell migration
Antigen presentation
MHC CLASS-II
PLASMACYTOID DENDRITIC CELLS
HEPATITIS-C VIRUS
T-CELLS
MOLECULAR CHARACTERIZATION
MEMBRANE MICRODOMAIN
SIGNALING COMPLEXES
PEPTIDE COMPLEXES
DISTINCT SUBSET
DOWN-REGULATION
description Professional antigen-presenting cells (APCs) include dendritic cells, monocytes, and B cells. APCs internalize and process antigens, producing immunogenic peptides that enable antigen presentation to T lymphocytes, which provide the signals that trigger T-cell activation, proliferation, and differentiation, and lead to adaptive immune responses. After detection of microbial antigens through pattern recognition receptors (PRRs), APCs migrate to secondary lymphoid organs where antigen presentation to T lymphocytes takes place. Tetraspanins are membrane proteins that organize specialized membrane platforms, called tetraspanin-enriched microdomains, which integrate membrane receptors, like PRR and major histocompatibility complex class II (MHC-II), adhesion proteins, and signaling molecules. Importantly, through the modulation of the function of their associated membrane partners, tetraspanins regulate different steps of the immune response. Several tetraspanins can positively or negatively regulate the activation threshold of immune receptors. They also play a role during migration of APCs by controlling the surface levels and spatial arrangement of adhesion molecules and their subsequent intracellular signaling. Finally, tetraspanins participate in antigen processing and are important for priming of naive T cells through the control of T-cell co-stimulation and MHC-II-dependent antigen presentation. In this review, we discuss the role of tetraspanins in APC biology and their involvement in effective immune responses.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-11-22
2018
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/6667
url http://hdl.handle.net/20.500.12105/6667
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission http://dx.doi.org/10.13039/501100000780 Seventh Framework Programme 294340
ES SAF2014-54705-R Not available
ES SAF2017-82886-R Not available
ES B2017 BMD-3671-INFLAMUNE
ES PIE13 00041
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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